| Scenea Ecosystem Ltd | Professional & scientific | 2026 |
| Scenic Homes (Lincs) Limited | Construction | 2025 |
| Scenic Homes Construction Limited | Construction | 2026 |
| Scenic Homes Development Limited | Construction | 2022 |
| Scenic Homes Ltd | Construction | 2019 |
| Schofield House Limited | Real estate | 2022 |
| School Inclusion Support Ltd | Education | 2022 |
| Scissor Steel Ltd | Other services | 2020 |
| Scotney Holdings Limited | Financial services | 2021 |
| Scott Park Developments Ltd | Construction | 2019 |
| Scott-Mance Quality Services Ltd | Professional & scientific | 2023 |
| Scrub a DUB Cleaning Club Ltd | Administrative & support | 2024 |
| SD1081 Ltd | Transport & logistics | 2025 |
| SDB Properties (Lincs) Ltd | Real estate | 2026 |
| SDF Agriculture Ltd | Agriculture & fishing | 2015 |
| SDS Driveways and Property Maintenance Ltd | Administrative & support | 2026 |
| Sea Dog Bamse Limited | Information & communication | 2006 |
| Sea Island Estates Ltd | Construction | 2025 |
| Sea Trek Ltd | Construction | 2011 |
| Seacroft Fashion Limited | Wholesale & retail | 2020 |
| Seagate (UK) Investments Ltd | Real estate | 2001 |
| Seagate Homes (UK) Ltd | Construction | 2008 |
| Seagate Homes Crowland Limited | Construction | 2017 |
| Seagate Homes Holdings Ltd | Professional & scientific | 2008 |
| Seagate Homes Limited | Construction | 2008 |
| Seagate Homes Monks House Lane Limited | Construction | 2019 |
| Seal Select Products Limited | Wholesale & retail | 2007 |
| Sean O'Hare Ltd | Transport & logistics | 2025 |
| Search Direct Limited | Extraterritorial | 2005 |
| Seas END Retreats Ltd | Real estate | 2023 |
| Seb-Trans Ltd | Transport & logistics | 2015 |
| Sebi Service Ltd | Transport & logistics | 2015 |
| Second Drove Management Company Limited | Households | 1984 |
| Secure Accommodation Furniture and Equipment Ltd | Manufacturing | 2014 |
| Security Development & Training Ltd | Administrative & support | 2021 |
| Sedge Estate Agents Ltd | Real estate | 2009 |
| SEEP1 Ltd | Administrative & support | 2025 |
| Select Timber Products Limited | Manufacturing | 1989 |
| Selective Roofing Solutions Ltd | Construction | 2026 |
| Selvador Ltd | Professional & scientific | 2020 |
| Selvatiles Solutions Ltd | Professional & scientific | 2020 |
| Semma DE Casa Ltd | Real estate | 2024 |
| Seniorspoon Ltd | Manufacturing | 2026 |
| Sennen Homes Limited | Construction | 2020 |
| Sentinel Group Property Limited | Hospitality | 2022 |
| Separt Limited | Construction | 2021 |
| Seren (Essex) Limited | Real estate | 2021 |
| Sergiu Dixon Ltd | Transport & logistics | 2024 |
| Sergo Trans Ltd | Transport & logistics | 2021 |
| Sergu Ltd | Transport & logistics | 2025 |
| Seroj Ltd | Hospitality | 2026 |
| Servicedb Ltd | Transport & logistics | 2025 |
| Settle Comics Ltd | Information & communication | 2025 |
| SEVEN22 Architecture Limited | Administrative & support | 2019 |
| Sfitlic Ltd | Transport & logistics | 2018 |
| SFK Civils Ltd | Construction | 2017 |
| SFR Flowers & Plants Limited | Wholesale & retail | 2025 |
| SFR Flowers Limited | Wholesale & retail | 2014 |
| SFR Plants Ltd | Wholesale & retail | 2023 |
| SG Transportation Ltd | Transport & logistics | 2025 |
| Sgph (Lincs) Ltd | Construction | 2023 |
| SGW Holdings Limited | Financial services | 2015 |
| Shadow Consultancy Limited | Administrative & support | 2003 |
| Shadylawson Ltd | Public administration | 2025 |
| Sharistone Management Ltd | Administrative & support | 2014 |
| Sharon Brinkman Care Services Ltd | Health & social care | 2014 |
| Shaun Kennedy Limited | Construction | 2014 |
| Sheard Property Management Limited | Real estate | 2019 |
| Sheila's Cars Ltd | Wholesale & retail | 2026 |
| Sherston Associates Limited | Real estate | 1998 |
| Shield Fortis Ltd | Professional & scientific | 2025 |
| Shining Light Counselling CIC | Health & social care | 2023 |
| Shiny Fairies Cleaning Services Ltd | Administrative & support | 2021 |
| Shire Home Improvements Ltd | Construction | 2026 |
| Sholtsgate Nursery Limited | Wholesale & retail | 2003 |
| Shop Retail Services Limited | Administrative & support | 2021 |
| SHOP4 ALL Electrical Ltd | Wholesale & retail | 2009 |
| Shopogolik Limited | Wholesale & retail | 2009 |
| Shortlands Ltd | Professional & scientific | 2006 |
| SHS Consultancy Services Ltd | Professional & scientific | 2025 |
| Shumba Healthcare Limited | Health & social care | 2014 |
| SID Dennis & Sons Properties Limited | Real estate | 2009 |
| SID Dennis and Sons Holdings Limited | Professional & scientific | 2005 |
| Siekiera Company Limited | Transport & logistics | 2025 |
| Siggy Ltd | Transport & logistics | 2024 |
| Sign Design Services Limited | Manufacturing | 1989 |
| Signal Stax Ltd | Wholesale & retail | 2026 |
| Signature Driveways Ltd | Construction | 2018 |
| Signature Paving Landscaping Limited | Construction | 2026 |
| Signmanor Limited | Financial services | 2001 |
| Silk Horizon International Ltd | Wholesale & retail | 2026 |
| Silk Rose 25 Ltd | Hospitality | 2025 |
| Silver Acorn Developments Ltd | Real estate | 2015 |
| Silver and Sons Limited | Wholesale & retail | 2022 |
| Silver Skips Lincolnshire Limited | Water & waste | 2009 |
| SIM Express (Peterborough) Ltd | Transport & logistics | 2021 |
| Simas Engineering Ltd | Manufacturing | 2023 |
| Simkins Plumbing and Heating Ltd | Construction | 2025 |
| Simon Barker Services Ltd | Construction | 2006 |
| Simon Pearson Consultancy Limited | Construction | 2015 |