| ESTEEM2 Ltd | Real estate | 2026 |
| ETC Property Ltd | Real estate | 2024 |
| Ethan 17 Limited | Arts & recreation | 2019 |
| Ethos Care Ltd | Hospitality | 2023 |
| Ethos Coffee & Brunch Ltd | Hospitality | 2026 |
| Euan Busby Ltd | Professional & scientific | 2026 |
| European Fine Foods Ltd | Wholesale & retail | 2018 |
| Eva's Real Estate Ltd | Real estate | 2025 |
| Evelyn Contracting Ltd | Manufacturing | 2026 |
| Evelyn Finch Millinery Limited | Manufacturing | 2026 |
| Event Squared Ltd | Information & communication | 2020 |
| Eventsea LLP | | 2025 |
| Everell Court Management Company Limited | Households | 1972 |
| Everstone Hospitality Ltd | Hospitality | 2026 |
| Everybody Pilates (Franchising) Ltd | Arts & recreation | 2015 |
| Everybody Pilates Ltd | Arts & recreation | 2013 |
| Everybody Pilates WSR Ltd | Arts & recreation | 2024 |
| Everyday Roofing Trading Ltd | Construction | 2023 |
| EVI Consultants Ltd | Manufacturing | 2025 |
| Evisa Investments Ltd | Real estate | 2025 |
| Evlu Ltd | Wholesale & retail | 2021 |
| Evolve & Reputable Properties and Investments Ltd | Real estate | 2025 |
| Ewjf Ltd | Professional & scientific | 2021 |
| Exape Ltd | Wholesale & retail | 2024 |
| Excelente Ltd | Wholesale & retail | 2023 |
| Exchange Management Company Limited(The) | Households | 1986 |
| Exelcourt Limited | Hospitality | 2014 |
| Exmouth ROW Limited | Households | 2022 |
| Exquisite Decay Media Ltd | Information & communication | 2025 |
| Extreme Robots Ltd | Arts & recreation | 2022 |
| EYE Tracking Systems Ltd | Manufacturing | 2020 |
| Eze-Move Canine Hydrotherapy & Physiotherapy Ltd | Other services | 2025 |
| F a Property Management Ltd | Real estate | 2017 |
| F.Edwards Holdings Ltd | Information & communication | 2026 |
| Fabtech Welding & Fabrication Limited | Manufacturing | 2002 |
| Fabulous Minds Hypnotherapy Ltd | Health & social care | 2023 |
| Faceted Beauty Ltd | Other services | 2017 |
| Facetsnkarats Ltd | Wholesale & retail | 2025 |
| Fairgroves Estate Agents Ltd | Real estate | 2019 |
| Fairy Cleaners UK Ltd | Administrative & support | 2024 |
| Fall Line Solutions Ltd | Information & communication | 2025 |
| Famao Estate Agents Ltd | Real estate | 2025 |
| Fandango (Portsmouth) Ltd | Manufacturing | 2015 |
| Fanteli Ltd | Professional & scientific | 2020 |
| Faredale Ltd | Professional & scientific | 2025 |
| Fareham Flavours Limited | Hospitality | 2017 |
| Fargoes Ltd | Wholesale & retail | 2024 |
| Farhad Barber Limited | Other services | 2018 |
| Farmar Investments Limited | Real estate | 2007 |
| Farmer Building Solutions Ltd | Construction | 2024 |
| Farmhouse Kitchen (London) Limited | Hospitality | 2024 |
| Farmhouse Sanctuary Events Ltd | Arts & recreation | 2026 |
| Fastpaced Lean Coaching Limited | Professional & scientific | 2015 |
| Fatbebe Ltd | Hospitality | 2025 |
| Fawcett Grill Ltd | Hospitality | 2020 |
| Fawcett Road Management Limited | Real estate | 2006 |
| FC Zeus Limited | Transport & logistics | 2016 |
| Fellerman Ltd | Administrative & support | 2020 |
| Fencecraft Landscapes Limited | Administrative & support | 2025 |
| Fenton Court RTM Company Limited | Administrative & support | 2009 |
| Fernando Property Ltd | Real estate | 2018 |
| Ferndale Finishing Limited | Construction | 2012 |
| Ferry House Inns Ltd | Hospitality | 2021 |
| Ferryman-Southsea Limited | Hospitality | 2006 |
| FGC Southern Limited | Construction | 2024 |
| Fidgety Pixels Ltd | Information & communication | 2018 |
| Field GUN Sport Ltd | Education | 2020 |
| Filer Property Group Limited | Financial services | 2019 |
| Finaple Financial Solutions Limited | Financial services | 2025 |
| Finest Mortgages and Protection Ltd | Financial services | 2020 |
| Fintech Talent Limited | Administrative & support | 2024 |
| Fireside Group Limited | Information & communication | 2018 |
| First Class Refurbishments Limited | Construction | 2015 |
| FIRST4GUESTS Ltd | Hospitality | 2016 |
| Firstforguests Ltd | Hospitality | 2016 |
| Fitdev Ltd | Information & communication | 2017 |
| Fitnesstmb Ltd | Other services | 2021 |
| Five Star Transport Limited | Financial services | 2004 |
| Fiveleaf Ltd | Professional & scientific | 2023 |
| FIX UP Look Sharp Ltd | Construction | 2018 |
| Flame Lettings Ltd | Real estate | 2021 |
| Flame Properties Ltd | Real estate | 2021 |
| Flavor Drip Ltd | Manufacturing | 2025 |
| Flavour Curry Ltd | Hospitality | 2025 |
| Flex Foot and Ankle Clinic Ltd | Health & social care | 2023 |
| Flintlock Limited | Professional & scientific | 2015 |
| Flintlock Marketing Limited | Professional & scientific | 2014 |
| Flooring and Build by A.Friend Ltd | Construction | 2016 |
| Florence Hotels Southsea Ltd | Hospitality | 2026 |
| Florian House Ltd | Hospitality | 2026 |
| Florios D'Italia Ltd | Hospitality | 2021 |
| Flowers by Alison Portsmouth Ltd | Wholesale & retail | 2022 |
| Flozeus Costruct Ltd | Construction | 2022 |
| Flux and Shield Fabrications Ltd | Manufacturing | 2017 |
| FM Sparkle Cleaning Service Ltd | Administrative & support | 2025 |
| Fobdown Management Company Limited | Professional & scientific | 2017 |
| Focus Travel Ltd | Administrative & support | 2015 |
| Fonfu Ltd | Other services | 2019 |
| Forever in Print Ltd | Information & communication | 2022 |
| Forge Barbell Ltd | Arts & recreation | 2024 |