| Rope Access NDT Inspection Ltd | Professional & scientific | 2012 |
| Rori (NW) Ltd | Health & social care | 2020 |
| Rosa Commercial Ltd | Financial services | 2025 |
| Rosa Mortgages Ltd | Financial services | 2022 |
| Rose Hill Southport Ltd | Real estate | 2022 |
| Rosebank Care Home Limited | Health & social care | 2014 |
| Rosehill (Aughton) Management Company Limited | Households | 2021 |
| Rosemary Court Management Limited | Households | 2002 |
| Rosenbloom Retail Ltd | Wholesale & retail | 2019 |
| Ross Jones Limited | Administrative & support | 2012 |
| Rossis Ice Cream (Southport) Limited | Wholesale & retail | 2025 |
| Rosslyn Court RTM Company Limited | Households | 2026 |
| Rostron Ltd. | Professional & scientific | 1991 |
| Rosu Trans Ltd | Transport & logistics | 2022 |
| Roundabout Garages Limited | Wholesale & retail | 2015 |
| Rovastock Limited | Hospitality | 2024 |
| Rowan Place Management Company Limited | Households | 1989 |
| Rowena Services Ltd | Administrative & support | 2020 |
| Rowland Fairfield Estates Ltd | Construction | 2025 |
| Roxby Training Solutions Ltd. | Professional & scientific | 2010 |
| ROY Lloyd Limited | Wholesale & retail | 1986 |
| Royal Birkdale Golf Club Merchandising Company Limited(The) | Arts & recreation | 1982 |
| Royal Leads Ltd | Administrative & support | 2020 |
| RPC Building Contractors Ltd | Construction | 2021 |
| RPE Resources International (UK) Limited | Wholesale & retail | 2023 |
| RR Group Services Ltd | Other services | 2024 |
| Rsdistrubtion Ltd | Wholesale & retail | 2025 |
| Rsha Ltd | Households | 2024 |
| RSL Waste Limited | Water & waste | 2020 |
| RT Event & Education Ltd | Arts & recreation | 2008 |
| RTI Roofing Limited | Construction | 2003 |
| RTW Developments Ltd | Real estate | 2016 |
| RU & Rocka Limited | Wholesale & retail | 2023 |
| Rubberball Limited | Information & communication | 2012 |
| Rumours of Fleetwood MAC Ltd | Arts & recreation | 2016 |
| Ruvic Management Consultants Limited | Professional & scientific | 2005 |
| RX Cafe Ltd | Hospitality | 2026 |
| Ryan Hiley Ltd | Construction | 2018 |
| RYAN2016 Limited | Transport & logistics | 2019 |
| Rydal Self Drive Ltd | Administrative & support | 2013 |
| Rylands Plant Hire Limited | Professional & scientific | 2001 |
| S & G Holding Group Ltd | Information & communication | 2016 |
| S & G Technical Services Limited | Manufacturing | 2011 |
| S & S Tyres & Auto Services Limited | Wholesale & retail | 2013 |
| S & T Knitwear Manufacturing Limited | Manufacturing | 1994 |
| S a Wine Bar Ltd | Hospitality | 2016 |
| S and L Harrison Limited | Other services | 2015 |
| S C Farrington Produce Ltd | Agriculture & fishing | 2017 |
| S C Wrought Iron Designs Ltd | Manufacturing | 2017 |
| S J Horrocks Installations Ltd | Other services | 2019 |
| S Porter Construction Limited | Construction | 2017 |
| S Q & E Limited | Construction | 2006 |
| S&L Southport Ltd | Hospitality | 2016 |
| S. K. Corporation Limited | Real estate | 2006 |
| S. R. M. Panels Limited | Wholesale & retail | 2003 |
| S.B.P. (Southport) Limited | Professional & scientific | 2004 |
| S.E. Couriers Ltd | Transport & logistics | 2011 |
| S.E.C. Jetting Limited | Transport & logistics | 2008 |
| S.E.S. Ltd. | Administrative & support | 1995 |
| S.J. Hargreaves (Scrap Metal) Limited | Water & waste | 2003 |
| S.K. Company Trading Limited | Hospitality | 2008 |
| S.P. James Plastering & Building Limited | Construction | 2022 |
| S30 Project Consultancy Limited | Information & communication | 2014 |
| S95’S Limited | Administrative & support | 2025 |
| SAB Management Ltd | Hospitality | 2024 |
| Safe and Fast Ltd | Transport & logistics | 2024 |
| Safe House Bunkers Ltd | Construction | 2022 |
| Safety Link Limited | Education | 2024 |
| Safety Well-Done Ltd | Public administration | 2023 |
| Saghin Construction Ltd | Construction | 2022 |
| Sagittarius Health Limited | Information & communication | 2023 |
| Sahara 1 Southport Limited | Hospitality | 2023 |
| Sahara.Southport Ltd | Hospitality | 2019 |
| Sailbrand Limited | Wholesale & retail | 1984 |
| Sajata Ltd | Hospitality | 2019 |
| Salar SFC Limited | Hospitality | 2026 |
| Sales Mentoring Limited | Administrative & support | 2011 |
| Salestique Ltd | Wholesale & retail | 2026 |
| Salford Court Management Company Limited | Households | 1975 |
| Salon Partners Ltd | Administrative & support | 2026 |
| Salon Products Online UK Limited | Wholesale & retail | 2019 |
| Saltarch Trading Limited | Arts & recreation | 1987 |
| SAM Hurst Construction Ltd | Construction | 2021 |
| SAM Medical Ltd | Health & social care | 2014 |
| SAM Thai Restaurant Limited | Hospitality | 2022 |
| Samsonite Security Limited | Administrative & support | 2012 |
| Samuels Birkdale Ltd | Hospitality | 2023 |
| SAN Escobar Property Limited | Real estate | 2024 |
| Sand Royale Ltd | Real estate | 2012 |
| Sanda Investments (UK) Limited | Real estate | 2009 |
| Sandaloos Ltd | Real estate | 2015 |
| Sandbourne Court Management Limited | Households | 2023 |
| Sanderson Construction Group Ltd | Construction | 2017 |
| Sandford (NW) Limited | Agriculture & fishing | 2009 |
| Sandground Solutions Limited | Professional & scientific | 2025 |
| Sandgrounder Heritage Limited | Arts & recreation | 2019 |
| Sandgrounder Holdings Limited | Financial services | 2022 |
| Sandgrounder Property Limited | Real estate | 2017 |
| Sandgroundertrading Ltd | Wholesale & retail | 2025 |
| Sandiway Court Limited | Households | 1973 |