| Elma Fragrance Ltd | Wholesale & retail | 2025 |
| Eloquix Ltd | Education | 2022 |
| Elpida Labs Ltd | Information & communication | 2023 |
| Elter Consultancy Limited | Professional & scientific | 2022 |
| Elva Group Limited | Financial services | 2023 |
| Elysium Business Management Limited | Professional & scientific | 2019 |
| EM Online Ltd | Arts & recreation | 2011 |
| EM Syndicates Limited | Administrative & support | 2014 |
| EMA Capital Ltd | Construction | 2026 |
| Emdia Ltd | Wholesale & retail | 2019 |
| Ememorybox Ltd | Wholesale & retail | 2023 |
| Emerge Managment Limited | Other services | 2018 |
| Emerge Retail Limited | Wholesale & retail | 2009 |
| Emergence Records Ltd | Wholesale & retail | 2025 |
| Emican Limited | Arts & recreation | 1993 |
| EMK Electrical Ltd | Construction | 2016 |
| Emmie LOU Studio Ltd | Arts & recreation | 2025 |
| EMP Property Ltd | Real estate | 2025 |
| Emporium Liquids Limited | Wholesale & retail | 2016 |
| Emptystock Limited | Hospitality | 2019 |
| EMS Agency Ltd | Arts & recreation | 2023 |
| Endbutt Lane Podiatry Limited | Health & social care | 2018 |
| Endeavour Management & Investment Group Ltd | Real estate | 2025 |
| Endymion Associates Limited | Professional & scientific | 2002 |
| Energy Index Limited | Information & communication | 2007 |
| Energy Paradigm Solutions Ltd | Professional & scientific | 2022 |
| Enforth Management and Consultancy Services Ltd | Professional & scientific | 2022 |
| Engaging Therapy UK Ltd | Health & social care | 2019 |
| Engbus Services Ltd | Professional & scientific | 2012 |
| England's Golf Coast Limited | Professional & scientific | 2012 |
| Enhance Events Group Limited | Other services | 2023 |
| Enness Engineering Limited | Professional & scientific | 2026 |
| Enterprise Developments Limited | Real estate | 2000 |
| Entity Pictures Limited | Information & communication | 2019 |
| Enviro Clean Southport Ltd | Administrative & support | 2023 |
| Enviro Cool Maintenance UK Ltd | Construction | 2009 |
| Envirolawn Ltd | Construction | 2008 |
| Envirolawn Properties Ltd | Construction | 2017 |
| Environmental Detection Surveys Limited | Professional & scientific | 2011 |
| Environmental Drainage Ltd | Water & waste | 2019 |
| Enviroscaff Services Ltd | Construction | 2026 |
| Envirosport Maintenance Ltd | Arts & recreation | 2021 |
| EOS Electrical Services Ltd | Construction | 2025 |
| Ephydridae Ltd | Wholesale & retail | 2025 |
| Epic Landmark Limited | Real estate | 2023 |
| Epic New Media Ltd | Professional & scientific | 2010 |
| Epic Start Ltd | Wholesale & retail | 2023 |
| Epilepsy Commissioning Support Ltd | Health & social care | 2017 |
| Epiony Limited | Wholesale & retail | 2019 |
| EPR Hospitality Limited | Hospitality | 2019 |
| EQI Consultancy Limited | Administrative & support | 2002 |
| Equi Socials Ltd | Wholesale & retail | 2025 |
| Equidity Housing Group Limited | Real estate | 2026 |
| Equiemporium Limited | Wholesale & retail | 2014 |
| Equilibrium.Aero Ltd | Manufacturing | 2020 |
| Erbil(Uk) Ltd | Other services | 2019 |
| Eree Ltd | Professional & scientific | 2021 |
| Eric Baldwin Insurance Service Centre Ltd. | Real estate | 1975 |
| Eric Property Ltd | Real estate | 2022 |
| Erick's Limited | Transport & logistics | 2018 |
| Erik's Trans Ltd | Transport & logistics | 2020 |
| Eros Home Care Services Ltd | Health & social care | 2023 |
| ESD Site Services Ltd | Administrative & support | 2019 |
| Esmira's Beauty Room Limited | Other services | 2004 |
| Essandore Care Limited | Health & social care | 2007 |
| Essandore Corporate Services Limited | Professional & scientific | 2005 |
| Essandore Limited | Health & social care | 1997 |
| Essential Connections Lancs Ltd | Extraterritorial | 2015 |
| Essential Surveys Ltd | Professional & scientific | 2016 |
| Essentialwellbeing Limited | Health & social care | 2025 |
| Esuk Professional Service Ltd | Professional & scientific | 2012 |
| Ethios UK Ltd | Professional & scientific | 2025 |
| EU Shopper Ltd | Wholesale & retail | 2025 |
| Eunoia Associates LLP | | 2015 |
| Euro Asian Commerce Ltd | Hospitality | 2010 |
| Euro Asian Trading Ltd | Hospitality | 2010 |
| Euro Parts Finder Ltd | Wholesale & retail | 2018 |
| Euro Southport Mini Market Limited | Wholesale & retail | 2026 |
| Euromarket. 18 Ltd | Wholesale & retail | 2018 |
| European Environmental Controls Limited | Construction | 1990 |
| Evans Contractors Limited | Construction | 2000 |
| EVE & Adam Consultancy Ltd | Information & communication | 2018 |
| Evenmore Consulting Limited | Professional & scientific | 2010 |
| Evenmore Investments Limited | Administrative & support | 2012 |
| Events Asia Ltd | Hospitality | 2014 |
| Eventuality Initiatives Ltd. | Administrative & support | 2016 |
| Eventus Consulting (Europe) Limited | Professional & scientific | 2019 |
| Everest Lounge Limited | Hospitality | 2020 |
| Eversafe Surfaces Ltd | Construction | 2026 |
| Evgen Cars Ltd | Wholesale & retail | 2025 |
| Evolve Fire and Security Limited | Professional & scientific | 2019 |
| Evolve U - Fitness and Wellness for Life Limited | Other services | 2015 |
| Evonnie Limited | Health & social care | 2019 |
| Evrin Group Ltd | Households | 2025 |
| Evsil Properties Limited | Real estate | 1953 |
| EWM Psychology Ltd | Education | 2024 |
| EWX Properties Ltd | Households | 2024 |
| Exacta Medico-Legal Limited | Health & social care | 2008 |
| Excalibur Living Ltd | Hospitality | 2025 |
| Excel Care (England) Ltd | Health & social care | 2018 |