| Dcneurovital Ltd | Other services | 2025 |
| DCR Engineered Solutions Limited | Professional & scientific | 2024 |
| DD Shop Ltd | Wholesale & retail | 2026 |
| Dead Boss Games Ltd | Information & communication | 2025 |
| Dearlove Events Ltd | Professional & scientific | 2024 |
| Dearlove Talent Ltd | Administrative & support | 2026 |
| Debijoe African Food-Stores Ltd | Hospitality | 2025 |
| Deborah Ball Ltd | Professional & scientific | 2020 |
| Debra LEE People Consulting Limited | Administrative & support | 2013 |
| DECONTAMIN8 Services Ltd | Administrative & support | 2022 |
| DEEP6 Enterprises Ltd | Manufacturing | 2014 |
| Defence Barrister Direct Limited | Professional & scientific | 2018 |
| Defender Apparels Ltd | Wholesale & retail | 2024 |
| Defg Ltd | Transport & logistics | 2021 |
| Degen Ltd | Other services | 2008 |
| Deli MIO Ltd | Wholesale & retail | 2022 |
| Delibritaly Ltd | Extraterritorial | 2016 |
| Delightful Destiny Ltd | Real estate | 2022 |
| Delightful Properties Ltd | Real estate | 2022 |
| Dellaway Catering Limited | Hospitality | 2011 |
| Delta PLM Limited | Information & communication | 2019 |
| Delta Property Inspections Limited | Professional & scientific | 2026 |
| Deltaline Trading Limited | Wholesale & retail | 2000 |
| Deluxe Emporium Limited | Wholesale & retail | 2022 |
| Dencourt Limited | Real estate | 1994 |
| Denis Andrei Ltd | Transport & logistics | 2026 |
| Denis Nugent Ltd | Health & social care | 2011 |
| Denis’S Trans Limited | Transport & logistics | 2021 |
| Dentman UK Ltd | Wholesale & retail | 2008 |
| Denture Arts @ 23 Limited | Health & social care | 2021 |
| Derby Road (Southport) RTM Company Limited | Households | 2022 |
| Derek Klaassen Limited | Professional & scientific | 2023 |
| Derived Ltd | Wholesale & retail | 2024 |
| Dermalessence Aesthetics Clinic Limited | Other services | 2022 |
| Design Build Limited | Construction | 2018 |
| Desire Care Company Ltd | Health & social care | 2013 |
| Desjpj Limited | Hospitality | 2026 |
| DEV Byte Limited | Information & communication | 2015 |
| DEV Newco Ltd | Other services | 2022 |
| Develop One CW Ltd | Professional & scientific | 2012 |
| Developme Northwest CIC | Education | 2025 |
| Devernon Psychotherapy Ltd | Health & social care | 2025 |
| Devi's Demolition Services Ltd | Construction | 2019 |
| Devise Projects Ltd | Professional & scientific | 2019 |
| Devonrow Limited | Transport & logistics | 2018 |
| Dexli Ltd | Wholesale & retail | 2023 |
| DFB Plant Limited | Construction | 2016 |
| DG Rail Consultants Limited | Professional & scientific | 2021 |
| DG Security and Electrical Systems Limited | Construction | 2003 |
| DGC Electrical & Mechanical Ltd | Construction | 2020 |
| DGM Rail Ltd | Administrative & support | 2021 |
| DGR Brew&Bar Ltd | Hospitality | 2023 |
| DH Development Ltd. | Information & communication | 2012 |
| DH Transport Limited | Professional & scientific | 2023 |
| DHCH14 Limited | Health & social care | 2020 |
| DHCH2 Limited | Health & social care | 2020 |
| DHCH21 Limited | Health & social care | 2018 |
| DHCH22 Limited | Health & social care | 2019 |
| DHCH5 Limited | Health & social care | 2020 |
| DHCH6 Limited | Health & social care | 2020 |
| Diamond Lights & Motors Limited | Wholesale & retail | 2021 |
| Diamond Media Broadcasting Limited | Information & communication | 2018 |
| Diamond Professionals Ltd | Information & communication | 2013 |
| Diamond Tyres Southport Ltd | Wholesale & retail | 2022 |
| Diana Shapcott Ltd | Health & social care | 2023 |
| Diane's Hot Food Delivery Services Ltd | Transport & logistics | 2025 |
| Digidog Tech Ltd | Information & communication | 2016 |
| Digidom Studios Limited | Information & communication | 2015 |
| Digital Co-Production Limited | Information & communication | 2020 |
| Digital Inspire Limited | Wholesale & retail | 2025 |
| Digital Marketing Whirled Limited | Professional & scientific | 2024 |
| Digital Sparkx Ltd | Information & communication | 2017 |
| Digitalaid Limited | Wholesale & retail | 2000 |
| Digitalcat Limited | Information & communication | 2015 |
| Digitide Ltd | Professional & scientific | 2026 |
| Dilan 1 Limited | Households | 2023 |
| Dilinger Estates Ltd | Administrative & support | 2023 |
| Dilinger Ltd. | Wholesale & retail | 2009 |
| Dining Ventures Ltd | Hospitality | 2016 |
| Diniz Duarte Transport Limited | Transport & logistics | 2015 |
| Dino Park Southport Limited | Arts & recreation | 2015 |
| Direct Conveyancing UK Limited | Administrative & support | 2002 |
| Direct Seafoods Limited | Extraterritorial | 2014 |
| DIS1 Limited | Information & communication | 2015 |
| Disaster Assist Ltd | Administrative & support | 2021 |
| Discolates Ltd | Other services | 2025 |
| Discount D.I.Y. and Bathrooms Limited | Wholesale & retail | 1979 |
| Discretion Hearing Limited | Health & social care | 2017 |
| Distinction Security Limited | Administrative & support | 2019 |
| Distributed Technologies (UK) Limited | Information & communication | 1998 |
| Ditto Coffee Southport Limited | Hospitality | 2026 |
| Diva Coffee 1 Ltd | Hospitality | 2024 |
| Diverse Electrical Services Limited | Construction | 2000 |
| Diversity Health Limited | Health & social care | 2025 |
| Diversity Healthcare Limited | Administrative & support | 2009 |
| Divine Indian Limited | Hospitality | 2021 |
| Divinework Healthcare Limited | Health & social care | 2017 |
| DJ Plumbing Heating & Bathrooms Limited | Construction | 2019 |
| DJB Compliance Ltd | Information & communication | 2023 |
| DJB Financial Ltd | Professional & scientific | 2017 |