| Easybox Delivery Limited | Transport & logistics | 2025 |
| Easydon Healthcare Ltd | Health & social care | 2022 |
| Easyepub Limited | Extraterritorial | 2009 |
| Easyfix Home Maintenance Limited | Administrative & support | 2025 |
| Easygo Limited | Health & social care | 2016 |
| Easygoing Designs Ltd | Mining & quarrying | 2001 |
| Easypress Group Limited | Wholesale & retail | 2003 |
| Easypress Limited | Professional & scientific | 2015 |
| Easypress Technologies Limited | Information & communication | 2004 |
| Easytrade Global Ltd | Wholesale & retail | 2026 |
| Easytrade International Ltd | Wholesale & retail | 2026 |
| EAT DUE South Limited | Wholesale & retail | 2023 |
| EAT Sleep Create Limited | Information & communication | 2021 |
| EAT Sleep Explore Ltd | Wholesale & retail | 2016 |
| Eaton & Wright PUB Co Ltd | Hospitality | 2025 |
| Eaton Court (Southampton) Management Company Limited | Households | 2016 |
| EAV Developments Limited | Real estate | 2021 |
| Eazypath Ltd | Public administration | 2025 |
| EBA Performance Ltd | Professional & scientific | 2016 |
| Ebenar Properties Ltd | Real estate | 2019 |
| Ebenezer Global Network Ltd | Manufacturing | 2025 |
| Ebenezers (Hythe) Limited | Hospitality | 2010 |
| Ebko Properties Ltd | Real estate | 2023 |
| Ebmd Limited | Wholesale & retail | 2019 |
| Ebnnnt DEE Limited | Health & social care | 2018 |
| EC Exclusive Cars Ltd | Transport & logistics | 2018 |
| EC Finance Resource Limited | Financial services | 2016 |
| EC Podiatry Limited | Health & social care | 2011 |
| EC Southampton Ltd | Other services | 2026 |
| Ecaep Ltd | Professional & scientific | 2026 |
| Ecarlogical Limited | Wholesale & retail | 2017 |
| Eccleston Motion Picture Ltd | Information & communication | 2024 |
| Ecco Living Ltd | Professional & scientific | 2014 |
| ECG Networks Ltd | Information & communication | 2016 |
| Echargers UK Ltd | Wholesale & retail | 2026 |
| Echo CPL Limited | Health & social care | 2024 |
| Echo Growth Ltd | Information & communication | 2025 |
| Echo Talent and Recruitment Ltd | Administrative & support | 2022 |
| Echo View Ltd | Information & communication | 2018 |
| Echoshore Ltd | Information & communication | 2025 |
| Echowave Media Group Ltd | Professional & scientific | 2025 |
| Echowing Limited | Information & communication | 2025 |
| Eciton Corp Ltd | Wholesale & retail | 2024 |
| Eclass Limited | Transport & logistics | 2020 |
| Eclips Hairdressing Limited | Other services | 2000 |
| Eclipse Cleaning Contractors Limited | Administrative & support | 2016 |
| Eclipse Coatings Limited | Administrative & support | 2017 |
| Eclipse Gymnastics CIC | Arts & recreation | 2016 |
| Eclipse Projects Ltd | Manufacturing | 2015 |
| Eco Apparel Ltd | Wholesale & retail | 2023 |
| Eco Education Ltd | Public administration | 2025 |
| Eco Green Cars Ltd. | Other services | 2018 |
| Eco Smart Trans Ltd | Transport & logistics | 2019 |
| Eco Technological Solutions Limited | Professional & scientific | 2011 |
| Eco Terra Polymers Ltd | Wholesale & retail | 2025 |
| Eco Tyres Global Limited | Wholesale & retail | 2014 |
| Eco Tyres Holdings Limited | Financial services | 2018 |
| Eco-Cleans Cleaning Solutions Ltd | Administrative & support | 2024 |
| Eco-Homes for YOU Limited | Construction | 2020 |
| Eco-Star Electrical Contracting Ltd | Construction | 2025 |
| Ecocoms Ltd | Information & communication | 2026 |
| Ecofeel Limited | Professional & scientific | 2012 |
| Ecoglow Cleaning Services Ltd | Administrative & support | 2025 |
| Ecologic Developments Limited | Manufacturing | 2010 |
| Ecom Consultants Limited | Information & communication | 2025 |
| Ecom Online Ventures Limited | Wholesale & retail | 2020 |
| Ecombrit Ltd | Wholesale & retail | 2024 |
| Ecomm Product Bazaar Limited | Wholesale & retail | 2025 |
| Ecosnap Ltd | Wholesale & retail | 2025 |
| Ecotaskforce Ltd | Professional & scientific | 2026 |
| Ecotech Mechanical Limited | Construction | 2026 |
| Ecotronik Ltd | Health & social care | 2015 |
| Ecowood Limited | Extraterritorial | 2009 |
| ECS Consultancy Limited | Professional & scientific | 2025 |
| ECT Property Investments Ltd | Other services | 2020 |
| ECY Transport Service Ltd | Transport & logistics | 2026 |
| ED Joseph Ltd | Professional & scientific | 2017 |
| Edbrook Fit Outs Limited | Construction | 2019 |
| Edda Crewing Services Limited | Administrative & support | 2015 |
| Eddie's Stem Works Ltd. | Education | 2023 |
| Eddies Liquor Store Limited | Wholesale & retail | 2015 |
| Eddtec Ltd | Information & communication | 2026 |
| Eden Beauty Hollybank Limited | Other services | 2015 |
| Eden Central Holdings Ltd | Financial services | 2025 |
| Eden Estate Properties Ltd | Real estate | 2024 |
| Eden Grange RTM Company Limited | Administrative & support | 2018 |
| Eden Hair Hollybank Ltd | Other services | 2025 |
| Eden Health Group Limited | Administrative & support | 2025 |
| Eden Southampton Limited | Construction | 2024 |
| Eden Therapy Centre Ltd | Health & social care | 2011 |
| Edge Southern Electrical Ltd | Construction | 2026 |
| Edge Southern Ltd | Construction | 2015 |
| Edge Technology Power Limited | Wholesale & retail | 2004 |
| Edgewave Limited | Arts & recreation | 2012 |
| Edgington PUB Co Ltd | Hospitality | 2022 |
| EDI Property & Facilities Services Limited | Administrative & support | 2017 |
| Edinasemedo Ltd | Other services | 2026 |
| Edinburgh Operational Research Corporation Ltd | Information & communication | 2025 |
| Edison Green Estate Agents Ltd | Real estate | 2019 |
| Edison Watt Ltd | Administrative & support | 2024 |