| Saghir & Sons Food Limited | Wholesale & retail | 2020 |
| Sagitta Consulting Ltd | Professional & scientific | 2013 |
| Sahota Transport Ltd | Transport & logistics | 2019 |
| Sahu EYE Care Limited | Health & social care | 2014 |
| SAI Bala Ltd | Real estate | 2024 |
| Said Systems Limited | Administrative & support | 2015 |
| Saifabbasi Ltd | Wholesale & retail | 2021 |
| Sail Power Ltd | Arts & recreation | 2024 |
| Sail Safer Charter Consultants Ltd | Professional & scientific | 2023 |
| Sail Squad Limited | Arts & recreation | 2014 |
| Sailcloth and Fabric Technology Limited | Wholesale & retail | 2020 |
| Sailhouse Ltd | Real estate | 2025 |
| Sailhouse Marine Ltd | Professional & scientific | 2025 |
| Sailhouse Property Ltd | Real estate | 2025 |
| Sailing Course Online Ltd | Education | 2019 |
| Sailing Grace Ltd | Administrative & support | 2017 |
| Sailing Hounds Ltd | Administrative & support | 2025 |
| Sailors' Society | Health & social care | 1905 |
| Sailors'Beneficial Enterprises Limited | Professional & scientific | 1998 |
| Sails of Merit Limited | Manufacturing | 2015 |
| Sain Baba Dermatology Ltd | Health & social care | 2014 |
| Saindhureddy Ltd | Hospitality | 2024 |
| Saint LA Mode Ltd | Wholesale & retail | 2020 |
| Saint Mary's Films Limited | Information & communication | 2023 |
| Saint Ronans Management Limited | Households | 2004 |
| Saintagathe Care Services Limited | Transport & logistics | 2022 |
| Saints Foundation (SFC) | Arts & recreation | 2001 |
| Saints Local Ltd | Wholesale & retail | 2025 |
| Saints PH Ltd | Hospitality | 2023 |
| Saja Suraga Limited | Real estate | 2007 |
| Sajdah Ltd | Information & communication | 2008 |
| Sajo Holdings Ltd | Financial services | 2018 |
| Sajo Living Ltd | Hospitality | 2013 |
| Sajo Property Ltd | Hospitality | 2000 |
| Sajo SA Management Ltd | Hospitality | 2018 |
| Sajo Smhq Ltd | Hospitality | 2018 |
| Sajo Ventures Ltd | Professional & scientific | 2011 |
| Sakib IT Solution Ltd | Information & communication | 2025 |
| Salar&Co Ltd | Wholesale & retail | 2024 |
| Salarian Homes Ltd | Construction | 2020 |
| Salebanger Ltd | Wholesale & retail | 2025 |
| Saleh Food Ltd | Hospitality | 2023 |
| Sales Expansion Limited | Professional & scientific | 2019 |
| Salesachiever.Net Ltd | Information & communication | 1989 |
| Saleschange Limited | Transport & logistics | 1980 |
| Salespuzzle Ltd | Information & communication | 2026 |
| Salina Mekitarian Growth Ltd | Wholesale & retail | 2025 |
| Salisbury & District Value Cars Limited | Transport & logistics | 1999 |
| Salisbury Medical Solutions Limited | Health & social care | 2017 |
| Salisbury Road Amesbury Ltd | Construction | 2018 |
| Salkeld & SON Holdings Limited | Real estate | 2024 |
| Salon Forte Ltd | Other services | 2022 |
| Salon Supplies Limited | Wholesale & retail | 2004 |
| Salon Supplies of Crewe Ltd | Wholesale & retail | 2004 |
| Salpra Ltd | Construction | 2025 |
| Salterns Boatyard Limited | Transport & logistics | 2022 |
| Saltface Limited | Wholesale & retail | 2024 |
| Salvay Group Ltd | Financial services | 2021 |
| Salvay Property Management Ltd | Real estate | 2021 |
| Salvis Energy Services Ltd | Professional & scientific | 2018 |
| Salvis Engineering Services Ltd | Professional & scientific | 2018 |
| Salvis Group Ltd | Professional & scientific | 2017 |
| Salvis Property Services Ltd | Real estate | 2018 |
| SAM Eden Ltd | Water & waste | 2022 |
| SAM Marine Ltd | Professional & scientific | 2018 |
| SAM Mazerenganwa Ltd | Health & social care | 2015 |
| SAM Partners Ltd | Financial services | 2026 |
| SAM Richmond Ltd | Health & social care | 2026 |
| SAM Store Southampton Ltd | Wholesale & retail | 2025 |
| Sam-Works UK Ltd | Wholesale & retail | 2010 |
| Sama Line Ltd | Real estate | 2023 |
| Saman Shawarma Ltd | Hospitality | 2026 |
| Samantha Adams Medical Aesthetics UK Limited | Health & social care | 2021 |
| Samantha Bramley Coaching and Consulting Ltd | Professional & scientific | 2018 |
| Samara James Retail Limited | Wholesale & retail | 2006 |
| Sambavision Corporation Limited | Information & communication | 2016 |
| Sameday General Garden Services Ltd | Administrative & support | 2021 |
| Sami Swoi Shop Limited | Wholesale & retail | 2008 |
| Samlexcare Limited | Administrative & support | 2019 |
| Sammy Music & Sounds Limited | Information & communication | 2026 |
| Samphire and Sage Ltd | Professional & scientific | 2025 |
| Samrad Music Ltd | Arts & recreation | 2025 |
| Samsara Solutions International Limited | Health & social care | 2016 |
| Samson Plant Limited | Manufacturing | 2008 |
| Samstream Ltd. | Real estate | 2010 |
| Samuel Properties Limited | Construction | 1999 |
| Samuel Wise Consulting Ltd | Professional & scientific | 2015 |
| Samy Transport Ltd | Transport & logistics | 2023 |
| Samya Life Sciences Ltd | Wholesale & retail | 2025 |
| Sana One Ltd | Transport & logistics | 2023 |
| Sanchin Financial Solutions Limited | Real estate | 2010 |
| Sanché Studios Ltd | Wholesale & retail | 2019 |
| Sand GEO Holdings Ltd | Real estate | 2023 |
| Sand Geophysics Limited | Professional & scientific | 2013 |
| Sandawana Care Limited | Health & social care | 2020 |
| Sandawana Couriers Ltd | Manufacturing | 2022 |
| Sandbox Asset Management Ltd | Construction | 2014 |
| Sandbox Media Limited | Information & communication | 2022 |
| Sandell Court Ltd | Households | 2011 |
| Sanden & Sanden Holdings Ltd | Financial services | 2018 |