| S&M Property (Hants) Ltd | Real estate | 2024 |
| S&N Property Management Limited | Real estate | 2022 |
| S&S Coffee Ltd | Hospitality | 2017 |
| S&S Japan Hybrid Cars Repair Ltd | Wholesale & retail | 2026 |
| S&S Properties (Southern) Limited | Real estate | 2022 |
| S&T Car Wash Ltd | Administrative & support | 2019 |
| S&T Cover Holding Company Limited | Professional & scientific | 2009 |
| S'Monei Limited | Extraterritorial | 2022 |
| S-Imsy Ltd | Information & communication | 2024 |
| S-M Liberty Care Ltd | Real estate | 2020 |
| S-Minerals Limited | Wholesale & retail | 2016 |
| S. Dryer Builders Limited | Construction | 2012 |
| S. Philps GAS Services Ltd | Construction | 2003 |
| S.A.M. Solutions Limited | Information & communication | 1998 |
| S.A.S Building Services Romsey Ltd | Construction | 2022 |
| S.C.L Construction & Groundwork’S Ltd | Construction | 2026 |
| S.E.B. Electrical Contractors Ltd | Construction | 2022 |
| S.E.G. (Preservation) Limited | Administrative & support | 1973 |
| S.G.P. Services Limited | Manufacturing | 2005 |
| S.G.S Aircooled Limited | Wholesale & retail | 2019 |
| S.Hardie HTS Limited | Wholesale & retail | 2025 |
| S.I.J. Promotions Limited | Real estate | 2010 |
| S.J. Estates Limited | Construction | 2004 |
| S.M.A.R.T Automotive Hampshire Ltd | Wholesale & retail | 2018 |
| S.N.A. Properties Limited | Real estate | 2004 |
| S.N.G Group Holdings Limited | Financial services | 2022 |
| S.N.G Healthcare Limited | Administrative & support | 2020 |
| S.N.G Recruitment Solutions Limited | Administrative & support | 2022 |
| S.N.G. Mechanical Limited | Construction | 2006 |
| S.N.T. Transport Ltd | Transport & logistics | 2022 |
| S.O PUB Ltd | Hospitality | 2026 |
| S.Richards Engineering Ltd | Professional & scientific | 2025 |
| S.S. Tiling Ltd | Construction | 2020 |
| S.T.R.L. Limited | Hospitality | 1998 |
| S.W. Asgood ENG. Limited | Manufacturing | 1977 |
| S.W. Automotive Limited | Wholesale & retail | 1985 |
| S0SP Care Services Limited | Health & social care | 2014 |
| S28 Properties & Investments Ltd | Real estate | 2024 |
| S28 Trading Ltd | Education | 2024 |
| S4RV Ltd | Wholesale & retail | 2019 |
| S6 Barber Ltd | Other services | 2023 |
| SA BTL Ltd | Real estate | 2025 |
| SA Event Productions Limited | Information & communication | 2017 |
| SA Property Holdings & Management Ltd | Real estate | 2026 |
| SA Recruitments and Training Limited | Administrative & support | 2022 |
| SA South Limited | Hospitality | 2025 |
| SA Ventures (College Online) Ltd | Administrative & support | 2024 |
| SA Ventures (Tutello) Ltd | Information & communication | 2023 |
| Saaali Ltd | Information & communication | 2018 |
| Saadzey Ltd | Wholesale & retail | 2025 |
| Saamaj UK Limited | Real estate | 2017 |
| Saarthi Private Limited | Education | 2026 |
| Sabanal Ltd | Professional & scientific | 2019 |
| Sable Intl Ltd | Professional & scientific | 2015 |
| Sabre Commercial Investments Limited | Construction | 2020 |
| Sabre Consultancies Ltd | Administrative & support | 2024 |
| Sabre Workshop Ltd | Manufacturing | 2023 |
| Sabrecore Holdings Ltd | Construction | 2021 |
| Sabu Kurd Ltd | Transport & logistics | 2024 |
| Sacha Business Solutions Limited | Administrative & support | 2023 |
| Sacol Manufacturing Limited | Manufacturing | 1969 |
| Sacred Earth Retreats Ltd | Other services | 2026 |
| Sacred Monkey and the Healing Grove Ltd | Wholesale & retail | 2024 |
| Sacredground Limited | Extraterritorial | 1987 |
| Sacree Holdings Limited | Financial services | 2025 |
| Sadhu Master Hub Ltd | Health & social care | 2022 |
| Sadia's Trading Company Ltd | Wholesale & retail | 2018 |
| Sadlers Mill Holiday Lets Ltd | Hospitality | 2018 |
| Safa Fresh Cleaning Services & Pest Control Ltd | Administrative & support | 2026 |
| Safe Access Solutions (S) Ltd | Construction | 2014 |
| Safe City Fire Protection Ltd | Construction | 2025 |
| Safe Driving Services Ltd | Public administration | 2025 |
| Safe Hands Property Maintenance Ltd | Construction | 2014 |
| Safe New Futures | Education | 2001 |
| Safe Structural Designs Ltd | Professional & scientific | 2019 |
| Safe TM Services Limited | Construction | 2015 |
| Safe-Hands Mobility Travel Ltd | Transport & logistics | 2026 |
| SAFE2STAY Ltd | Administrative & support | 2020 |
| Safeguard Asbestos Removal Ltd | Transport & logistics | 2025 |
| Safenet Fire Limited | Professional & scientific | 2014 |
| Safeplus Limited | Extraterritorial | 2016 |
| Safer Care Systems Ltd | Administrative & support | 2026 |
| Saferide Cab's Limited | Transport & logistics | 2024 |
| Safespec Building Services Limited | Construction | 2006 |
| Safetrac Solutions Limited | Wholesale & retail | 2004 |
| Safety 1ST South Ltd | Other services | 2023 |
| Safety GAS Ltd | Construction | 2014 |
| Safety Monitors Limited | Wholesale & retail | 2017 |
| Safewaxaway Ltd | Health & social care | 2025 |
| Saffron Projects (UK) Limited | Construction | 2013 |
| Saffron Smoke Ltd | Hospitality | 2025 |
| Safi Cars Limited | Wholesale & retail | 2024 |
| Safi Store Ltd | Wholesale & retail | 2024 |
| Safiba Limited | Health & social care | 2017 |
| Safire Workforce Ltd | Manufacturing | 2021 |
| Saf’S Chicken Ltd | Hospitality | 2023 |
| Sagacity Properties Limited | Real estate | 2023 |
| Sage Kitchens Limited | Wholesale & retail | 2024 |
| Sage Travel Consulting Limited | Administrative & support | 2011 |
| Saggitarius Trans Limited | Transport & logistics | 2019 |