| Renovos Biologics Limited | Professional & scientific | 2017 |
| Rent a Goat Ltd | Agriculture & fishing | 2026 |
| Rent Southampton Ltd | Real estate | 2023 |
| Rent Zone Management Ltd | Real estate | 2025 |
| Rentabode Ltd. | Real estate | 2017 |
| Rental Nova Southampton Ltd | Real estate | 2025 |
| Rentezee Limited | Information & communication | 2018 |
| Rentrue Ltd | Information & communication | 2021 |
| Renwood Properties Limited | Real estate | 2021 |
| Renwood Scaffolding Limited | Construction | 2016 |
| Repair Bidco UK Limited | Financial services | 2023 |
| Repair Midco UK Limited | Financial services | 2023 |
| Repair My Shed Ltd | Other services | 2021 |
| Repair Topco UK Limited | Financial services | 2023 |
| Repaired Today Group Ltd | Wholesale & retail | 2022 |
| Repec Limited | Energy | 2003 |
| Repro Composites Ltd | Administrative & support | 2020 |
| Reps With Rubes Ltd | Arts & recreation | 2024 |
| Rera Group Limited | Financial services | 2025 |
| Reserveai Ltd | Information & communication | 2025 |
| Resflo Limited | Construction | 2022 |
| Resgen Ltd | Construction | 2025 |
| Residential Air Systems Ltd | Other services | 2017 |
| Residential Care Ltd | Health & social care | 2021 |
| Residential Properties Southampton Limited | Real estate | 2026 |
| Residential Property Surveys Ltd | Professional & scientific | 2025 |
| Resilience Marketing & PR Ltd | Professional & scientific | 2021 |
| Resivo Ltd | Wholesale & retail | 2024 |
| Resivoai Limited | Information & communication | 2025 |
| Resolute Construction and Plumbing Ltd | Construction | 2023 |
| Resonance Publications Limited | Information & communication | 2016 |
| Resonate Integrated Solutions Ltd | Professional & scientific | 2020 |
| Resourcer Ltd | Professional & scientific | 2017 |
| Response Development Training Limited | Administrative & support | 1995 |
| Response Maintenance and Repairs Limited | Manufacturing | 2022 |
| Restore Therapy Hampshire CIC | Health & social care | 2025 |
| Restored Eden Physiotherapy Ltd | Health & social care | 2022 |
| Resurgam (BH) Limited | Construction | 2022 |
| Resurgam Asset Management Limited | Real estate | 2022 |
| Resvo Limited | Real estate | 2025 |
| Retail Connect Ltd | Wholesale & retail | 2011 |
| Retail Netwerks UK Ltd | Administrative & support | 2012 |
| Retain & Guard Ltd | Manufacturing | 2024 |
| Retainer LAB Limited | Manufacturing | 2026 |
| Retro Culture Limited | Wholesale & retail | 2015 |
| Retro Ozzy Ltd | Wholesale & retail | 2025 |
| Retro Room Ltd | Other services | 2020 |
| Return Ticket Holdings Ltd | Professional & scientific | 2021 |
| Revara Events Ltd | Administrative & support | 2026 |
| Revealed EYE Ltd | Information & communication | 2024 |
| Reverse Time Limited | Health & social care | 2010 |
| Reviewthing Limited | Information & communication | 2022 |
| Revigo Ltd | Information & communication | 2026 |
| Revis Group Limited | Financial services | 2025 |
| Revitalise Gardens Ltd | Administrative & support | 2013 |
| Revival Powerboats LLP | | 2004 |
| Revival Yachts LLP | | 2005 |
| Revive and Renew Limited | Real estate | 2025 |
| Revive Construction and Renovation Ltd | Construction | 2013 |
| Revivex Lifesciences Limited | Wholesale & retail | 2024 |
| Revo Transport and Distribution Services Ltd | Wholesale & retail | 2011 |
| Revo Works Limited | Wholesale & retail | 2015 |
| Revo-G Ltd | Information & communication | 2024 |
| Revolt Autoworks Limited | Wholesale & retail | 2017 |
| Revolution Autos Limited | Wholesale & retail | 2023 |
| Revolution Boxing CIC | Education | 2025 |
| Revolution Care Limited | Health & social care | 2023 |
| Revolution Care Management Limited | Hospitality | 2015 |
| Revolution Caring 24/7 Limited | Health & social care | 2019 |
| Reward Well Limited | Extraterritorial | 2008 |
| Rewcastle & Sons Limited | Administrative & support | 1998 |
| REX Burger Ltd | Hospitality | 2023 |
| REX Drive UK Ltd | Transport & logistics | 2024 |
| Rexha Construction Ltd | Construction | 2024 |
| Reymos Limited | Financial services | 2018 |
| Reyna Logistics Ltd | Transport & logistics | 2025 |
| Reyno Ltd | Information & communication | 2011 |
| Reynolds Court(Management)Limited | Households | 1965 |
| Rezalla Ltd | Hospitality | 2018 |
| Rezz Solutions Limited | Information & communication | 2016 |
| Rezzho Ltd | Information & communication | 2026 |
| RF Design Projects Ltd | Professional & scientific | 2017 |
| RF Design Property Ltd | Real estate | 2024 |
| RF Group Holdings Limited | Real estate | 2015 |
| RF Property Group Limited | Real estate | 2015 |
| RFA Marine Ltd | Manufacturing | 2016 |
| Rfinity Care Solutions Ltd | Administrative & support | 2022 |
| RFW Ltd | Construction | 2004 |
| RG Aviation Services Limited | Manufacturing | 2022 |
| RG Care Homes Limited | Health & social care | 2017 |
| RG Security Ltd | Administrative & support | 2016 |
| RG Services South Ltd | Transport & logistics | 2024 |
| RG Signals Support Limited | Manufacturing | 2018 |
| RG Training Services Ltd | Transport & logistics | 2019 |
| RGA Freight Forwarding Ltd | Transport & logistics | 2026 |
| RGB Electrical Services Ltd | Construction | 2020 |
| RGM Installations Ltd | Construction | 2022 |
| RGS Building and Groundworks Limited | Construction | 2017 |
| RGS Formwork Limited | Construction | 2020 |
| RGS Property Solutions Ltd | Real estate | 2023 |