| Reporter RAY Limited | Information & communication | 2015 |
| Republica Limited | Professional & scientific | 1999 |
| Resolution Interiors Limited | Construction | 1998 |
| Reusable Steels Limited | Wholesale & retail | 2003 |
| Ribcraft Limited | Manufacturing | 1993 |
| Richard Coate Sheep Exports Limited | Agriculture & fishing | 1990 |
| Richmond Hotel Limited | Hospitality | 2005 |
| Richmond House Residents Company Limited | Households | 1982 |
| Rickshaw 2017 Limited | Hospitality | 2017 |
| RIGHT4UMAINTENANCE Ltd | Professional & scientific | 2015 |
| Rioja Consulting Limited | Professional & scientific | 2013 |
| Robert Bunn Office Furniture Limited | Administrative & support | 1998 |
| Rochford Sports Knitwear Ltd | Manufacturing | 2004 |
| Rogers Optical Limited | Wholesale & retail | 2014 |
| Roiweb Limited | Wholesale & retail | 2003 |
| Rosemount Capital Limited | Financial services | 2004 |
| Rotalink Limited | Manufacturing | 1936 |
| Rothwell & Dunworth Limited | Wholesale & retail | 2002 |
| Roundham Press Limited | Manufacturing | 1975 |
| Rowan Inns Limited | Hospitality | 1990 |
| Rowswell Construction Limited | Construction | 2003 |
| ROY Stroud & Co. Limited | Construction | 1955 |
| Royce Carpets Limited | Transport & logistics | 1990 |
| RPM Promotions Limited | Manufacturing | 1997 |
| RS Building and Carpentry Limited | Construction | 2016 |
| Rubix Solutions UK Limited | Professional & scientific | 2008 |
| Rumpus Design Limited | Information & communication | 2008 |
| Rynar Limited | Administrative & support | 1993 |
| S & S Scaffolding (South West) Limited | Construction | 2008 |
| S & W Polytunnel (UK) Limited | Manufacturing | 1978 |
| S H M Construction Ltd | Construction | 2004 |
| S. Notaro Holdings Limited | Financial services | 1999 |
| S. Notaro Land Limited | Professional & scientific | 2004 |
| S. Notaro Windows Limited | Construction | 1999 |
| S. R. Roles (Yeovil) Limited | Real estate | 1976 |
| S.L. Tyres Ltd | Wholesale & retail | 2021 |
| S.W.N. Structures Limited | Professional & scientific | 2002 |
| Sabelwood (Residential Lettings) Limited | Real estate | 1996 |
| Salt Express Limited | Wholesale & retail | 2003 |
| Sand Hall Limited | Agriculture & fishing | 1997 |
| Sandford Building Contractors (SW) Ltd | Construction | 2002 |
| Saunders Property Services Limited | Real estate | 2005 |
| Scarboroughs Limited | Administrative & support | 1978 |
| SCO Search Ltd | Administrative & support | 2019 |
| SDK Construction Limited | Construction | 2002 |
| Seaton Court Management Co Limited | Households | 2003 |
| Sedgemoor Snooker Club Limited | | 1986 |
| Sense IT Training & Consultancy Ltd | Information & communication | 2011 |
| Sensible M.B.I. Limited | Real estate | 1993 |
| Serious Structures Limited | Extraterritorial | 2012 |
| Sevco 3542 Limited | Real estate | 2003 |
| Severity Limited | Administrative & support | 2007 |
| Seymour Roofing Limited | Extraterritorial | 1976 |
| Shah & Shahs Peri Peri Ltd | Hospitality | 2019 |
| Shanael Farms Limited | Agriculture & fishing | 2005 |
| Shanghai Herbal Products Limited | Health & social care | 1999 |
| Sharnway Limited | Wholesale & retail | 1991 |
| Shaun Burton Transport Limited | Transport & logistics | 2007 |
| Shearmurs Garage Limited | Wholesale & retail | 2003 |
| Sheep CDY Co., Ltd | Extraterritorial | 2021 |
| Sheila Parr Limited | Professional & scientific | 2003 |
| Shellihurst Properties Limited | Real estate | 1975 |
| Sheppard & Barrow Limited | Transport & logistics | 1943 |
| Sheppy's Cider Limited | Manufacturing | 2007 |
| Sherborne Car Wash and Valeting Limited | Administrative & support | 2023 |
| Shining Star Future Care Co., Ltd | Wholesale & retail | 2021 |
| Shion Limited | Households | 2017 |
| Shire's Garage & Engineering Company,Limited | Wholesale & retail | 1947 |
| Shoecare | | 1993 |
| Silden Marketing Ltd | Manufacturing | 2007 |
| Silverstones Limited | Extraterritorial | 2002 |
| Singer Instrument Company Limited | Manufacturing | 1934 |
| Singleton Engineering (UK) Limited | Professional & scientific | 1992 |
| Situs Software Engineering Limited | Information & communication | 1994 |
| Skilltrain Associates Limited | Transport & logistics | 1997 |
| Skinflair Limited | | 1969 |
| SKN UK Healthcare Ltd | Health & social care | 2022 |
| Skyline Trans Limited | Transport & logistics | 2016 |
| Slabs R US Limited | Manufacturing | 2006 |
| Small Industries (Property) Limited | Real estate | 1986 |
| SMC Drylining Limited | Construction | 2005 |
| Snip Advisor Ltd | Administrative & support | 2010 |
| Somerset Cricket Museum Limited | Arts & recreation | 1985 |
| Somerset Long Barn Limited | Real estate | 2007 |
| Somerset Mortgage Brokers Limited | Administrative & support | 2001 |
| Somerset Window Repairs Ltd | Construction | 2022 |
| Sorbietrees Farm Limited | Agriculture & fishing | 1981 |
| South Somerset Mortgages Limited | Administrative & support | 2005 |
| South West Aberdeen-Angus Beef Limited | Wholesale & retail | 2002 |
| South West Cold Rooms Limited | Administrative & support | 2006 |
| South Western Garage Equipment Limited | Wholesale & retail | 2001 |
| Southwick Village Developments (BB) Limited | Real estate | 2024 |
| Space Interior Systems Limited | Construction | 2003 |
| Specialised Process Solutions Ltd | Manufacturing | 2002 |
| Spice Root Ajwa Ltd | Hospitality | 2025 |
| Spindlewood Woodturning Limited | Extraterritorial | 2007 |
| Spot-On-Supplies (Cleaning and Packaging) Limited | Wholesale & retail | 1975 |
| Spot-On-Supplies (Hygiene) Limited | Wholesale & retail | 1982 |
| Spot-On-Supplies (Industrial Consumables) Limited | Wholesale & retail | 1976 |
| Spot-On-Supplies Limited | Professional & scientific | 1985 |