| Skem TV Ltd | Information & communication | 2024 |
| Skembild Ltd | Construction | 2025 |
| Skemnews Limited | Information & communication | 2019 |
| SKL Pharma Limited | Health & social care | 2023 |
| SL Smith Ltd | Professional & scientific | 2024 |
| Smao Limited | Health & social care | 2018 |
| Smart Choice Supplies Limited | Administrative & support | 2013 |
| Smithonix Limited | Wholesale & retail | 2019 |
| Snappy Kidz Limited | Wholesale & retail | 2018 |
| Social Wellbeing CIC | Health & social care | 2021 |
| Socks Box Co Ltd | Manufacturing | 2021 |
| Softwaresync Consulting Ltd | Information & communication | 2023 |
| Solaplas Limited | Construction | 2006 |
| Solid Machinery Motors Ltd | Wholesale & retail | 2026 |
| Solid Sheds Limited | Manufacturing | 2010 |
| Solidbase NW Builders Limited | Construction | 2025 |
| Sophia Rentals Ltd | Real estate | 2026 |
| South West Lancashire Independent Community Advice Network Ltd | Administrative & support | 2002 |
| Southport Jazz Events CIC | Arts & recreation | 2022 |
| Sovereign Retail Limited | Wholesale & retail | 2025 |
| Sowden Shaw Limited | Professional & scientific | 2016 |
| Spartan Estates and Lettings Ltd | Real estate | 2025 |
| Spartan Flooring Specialists Ltd | Construction | 2019 |
| SPB Joinery Ltd | Construction | 2007 |
| Speedy Ranger Limited | Transport & logistics | 2017 |
| Spice Balti (Skelm) Limited | Hospitality | 2021 |
| Sportforge Ltd | Wholesale & retail | 2026 |
| Sprint Curier London Ltd | Transport & logistics | 2021 |
| Squaredeals (UK) Ltd | Wholesale & retail | 2010 |
| SSK Healthcare Limited | Wholesale & retail | 2025 |
| ST Convenience Store Ltd | Wholesale & retail | 2024 |
| ST Raphael's Dental Practice Limited | Health & social care | 2009 |
| ST. Richard's OUT of School Club | Education | 2008 |
| Stackright Ltd | Manufacturing | 2009 |
| Stackright North West Limited | Financial services | 2012 |
| Stan Drive Ltd | Transport & logistics | 2022 |
| Standing in Commerce Ltd | Professional & scientific | 2009 |
| Standish Metal Treatment Limited | Construction | 1991 |
| Stanley Way Holdings Ltd | Financial services | 2024 |
| Stapleton Care Limited | Health & social care | 2022 |
| Star Protection Limited | Financial services | 2023 |
| Starlight Stream Limited | Manufacturing | 2025 |
| Start Your Engine Ltd | Transport & logistics | 2021 |
| Stefanie NNA Limited | Wholesale & retail | 2025 |
| Stellar Pet Products Ltd | Wholesale & retail | 2023 |
| Sterling Health Solutions Limited | Real estate | 2018 |
| Sterling Motors (Skelmersdale) Limited | Wholesale & retail | 2017 |
| Steven Tilley Engineering Ltd | Professional & scientific | 2014 |
| Stocks Care Home Holdings Ltd | Health & social care | 2025 |
| Stocks Charnock Richard Ltd | Health & social care | 2025 |
| Stocks Hall Care Homes Limited | Health & social care | 1987 |
| Stocks Landco One Ltd | Financial services | 2025 |
| Stocks Landco Two Ltd | Health & social care | 2025 |
| Stocks Mawdesley Ltd | Health & social care | 2025 |
| Stocks Ormskirk Ltd | Health & social care | 2025 |
| Stone Alliance Services Ltd | Construction | 2017 |
| Stonehouse Tyld Limited | Professional & scientific | 2023 |
| Stonehut Properties Ltd | Real estate | 2021 |
| Strucad Design Services Limited | Professional & scientific | 1996 |
| Sturdy Print & Design Limited | Other services | 1978 |
| Sturdy Print Holdings Ltd | Financial services | 2022 |
| Style Thread Ltd | Wholesale & retail | 2024 |
| SU 138 Limited | Hospitality | 2026 |
| Suffolk Nutrition & Health Limited | Health & social care | 2019 |
| Sun Force Delivery Services Ltd | Transport & logistics | 2025 |
| Supawood Products Ltd | Wholesale & retail | 2012 |
| Supreme Cakes Ltd | Wholesale & retail | 2025 |
| Sureguard Supplies Ltd | Wholesale & retail | 2025 |
| Surface Transport Limited | Transport & logistics | 2011 |
| Survey & Engineering Programs Limited | Professional & scientific | 2019 |
| Survey & Engineering Projects Limited | Professional & scientific | 2004 |
| Survey & Engineering Solutions Ltd | Construction | 2022 |
| Survey Management Limited | Professional & scientific | 2019 |
| Sustainable Building Services (Southern) Limited | Construction | 2021 |
| Sustainable Building Services (UK) Limited | Construction | 1978 |
| Sustainable Building Solutions (UK) Limited | Administrative & support | 2011 |
| Sustainable Construction (UK) Limited | Administrative & support | 2011 |
| Sustainable Developments (UK) Limited | Construction | 2014 |
| Sustainable Energy Services (UK) Limited | Administrative & support | 2011 |
| Sustainable Group (UK) Limited | Professional & scientific | 2010 |
| Sustainable Housing Limited | Administrative & support | 2010 |
| Sustainable Insulation Solutions (UK) Limited | Administrative & support | 2011 |
| Sustainable Investments Limited | Professional & scientific | 2009 |
| Sustainable Renewable Solutions (UK) Limited | Administrative & support | 2011 |
| Sustainable Smart Technologies Ltd | Information & communication | 2017 |
| SV Heating Ltd | Extraterritorial | 2024 |
| SVR Plastics Limited | Manufacturing | 2000 |
| Swanhill Financial Ltd | Financial services | 2019 |
| Symphony Boats Ltd | Construction | 2021 |
| Synergrc Ltd | Information & communication | 2025 |
| Synergy Global Trade Ltd | Wholesale & retail | 2026 |
| Synergy Waste Solutions Ltd | Administrative & support | 2012 |
| T Franks GAS & Plumbing Ltd | Extraterritorial | 2017 |
| T Rooney Properties Limited | Real estate | 2016 |
| T Tomsone Limited | Administrative & support | 2023 |
| T&C Engineering Ltd | Manufacturing | 2022 |
| T-Rez Enterprise Ltd | Real estate | 2025 |
| T.Transport Ltd | Transport & logistics | 2024 |
| Taag Construction Ltd | Real estate | 2021 |
| Taag Steelwork Ltd | Manufacturing | 2007 |