| Ridgway Arms Limited | Hospitality | 2012 |
| Rigar Property Investments Ltd | Construction | 2018 |
| Riozzi Properties Limited | Real estate | 2026 |
| Ritchie John Mellor Engineering Ltd | Administrative & support | 2010 |
| Riverside Truck Rental Limited | Administrative & support | 1996 |
| RJM Truck Ltd | Transport & logistics | 2021 |
| RK Motor Vehicles Limited | Wholesale & retail | 2023 |
| RK Painting Limited | Construction | 2025 |
| RMC Recovery Ltd | Wholesale & retail | 2025 |
| Robbins Bridge Developments Limited | Real estate | 2014 |
| Robpar NO2 Limited | Professional & scientific | 2017 |
| ROKA73 Limited | Wholesale & retail | 2009 |
| Roll-A-Ball Limited | Arts & recreation | 2012 |
| Romancia Limited | Wholesale & retail | 2023 |
| Rooney Roofing Ltd | Construction | 2012 |
| Rope Access & NDT Services Limited | Extraterritorial | 2007 |
| Rose Crescent 1965 Limited | Extraterritorial | 2014 |
| Rothwell Investments (Property) Limited | Real estate | 2012 |
| Rothwell Investments Limited | Real estate | 2005 |
| Roughley Residential Limited | Real estate | 2026 |
| RPS (NW) Limited | Professional & scientific | 2014 |
| Rufford Meadow Fishery Ltd | Real estate | 2016 |
| Rushview Limited | Wholesale & retail | 1985 |
| Russ Abbot Limited | Arts & recreation | 1983 |
| Ryca Holdings Limited | Financial services | 2020 |
| Ryca Property Group Limited | Real estate | 2026 |
| S Coventry NDT Ltd | Professional & scientific | 2019 |
| S Payne Driving Force Ltd | Transport & logistics | 2014 |
| S. John Solutions Ltd | Transport & logistics | 2014 |
| S.Rooney Photography Ltd | Professional & scientific | 2021 |
| S23 Retail Ltd | Wholesale & retail | 2025 |
| SA2 Holdings Limited | Financial services | 2022 |
| Safe Pass Fire Door Solutions Ltd | Administrative & support | 2025 |
| Sainee Solutions Limited | Real estate | 2016 |
| Saint Talisman Limited | Wholesale & retail | 2023 |
| Sameday Hire I Ltd | Transport & logistics | 2025 |
| Samfit Property Maintenance Ltd | Extraterritorial | 2023 |
| Sandy Lane Property Services Ltd | Construction | 2017 |
| Sanko Gosei UK Ltd | Manufacturing | 1987 |
| Sapnu Buve Ltd | Construction | 2025 |
| Sapphire Externals Ltd | Construction | 2015 |
| Sash & Pepps Ltd | Wholesale & retail | 2022 |
| Sash-Thetics Ltd | Other services | 2025 |
| SB Skills Solutions Ltd | Education | 2013 |
| SBS Properties Limited | Construction | 2010 |
| School Coach Travel Limited | Transport & logistics | 2013 |
| SCM Global Services Ltd | Construction | 2025 |
| Scratch and Match Limited | Wholesale & retail | 2025 |
| Sculpte Body Contouring Ltd | Other services | 2025 |
| Sculthorpe Consulting Limited | Information & communication | 2010 |
| SD Interiors Ltd | Construction | 2024 |
| SD Squared Urban Lettings Ltd | Hospitality | 2026 |
| SDS Roofing Limited | Construction | 2013 |
| Sean Charles Interiors Ltd | Construction | 2019 |
| Securedeal Property Management Limited | Real estate | 1991 |
| Seddon Compliance Consultancy Ltd | Professional & scientific | 2022 |
| Seguro Group Ltd | Health & social care | 2016 |
| Select Property Sourcing Ltd | Real estate | 2020 |
| Sensory Overload Ltd | Wholesale & retail | 2025 |
| SEP Geophysical Limited | Professional & scientific | 2019 |
| SEP Hydrographic Limited | Professional & scientific | 2020 |
| SEP Inspection Limited | Professional & scientific | 2022 |
| SEP Interactive Limited | Professional & scientific | 2026 |
| SEP Renewables Limited | Professional & scientific | 2023 |
| SEP Survey Limited | Extraterritorial | 2020 |
| Sequoia Solutions Ltd | Information & communication | 2008 |
| Serving Health Nationally Ltd | Administrative & support | 2018 |
| SET Europe Limited | Professional & scientific | 2003 |
| Setstone Construction Ltd | Construction | 2014 |
| SFX Live Ltd | Extraterritorial | 2017 |
| Shadow Trading Ltd | Wholesale & retail | 2024 |
| Shares Lancashire | Education | 2010 |
| Sherriff Education Limited | Health & social care | 2017 |
| Shiiva Yoga Centres (UK) Ltd | Other services | 2015 |
| Shildon Smile Care Limited | Health & social care | 2019 |
| Shiny Grey Ltd | Professional & scientific | 2018 |
| Signal One Entertainment Ltd | Information & communication | 2015 |
| Silversands Property Limited | Real estate | 2025 |
| Simon Dean Ltd | Construction | 2020 |
| Simply DC Ltd | Wholesale & retail | 2023 |
| Simply Wear Ltd | Wholesale & retail | 2025 |
| Singhcorp Inc Limited | Extraterritorial | 2013 |
| Sips Projects Ltd | Professional & scientific | 2017 |
| SIX Acres Supported Accommodation Limited | Health & social care | 2011 |
| SJ by Design Limited | Construction | 2023 |
| SJH Property Group Ltd | Real estate | 2021 |
| SJL Printmedia Limited | Information & communication | 1999 |
| Skelmersdale Barber Ltd | Other services | 2022 |
| Skelmersdale Barber Shop Ltd | Other services | 2025 |
| Skelmersdale Build Ltd | Construction | 2025 |
| Skelmersdale Community Enterprise CIC | Professional & scientific | 2022 |
| Skelmersdale Maintenance Ltd | Construction | 2012 |
| Skelmersdale Skip Hire Ltd | Water & waste | 2006 |
| Skelmersdale Thai Boxing and MMA Academy Limited | Arts & recreation | 2016 |
| Skelmersdale Town FC Limited | Arts & recreation | 2026 |
| Skelmersdale Truck & Car Valeting Ltd | Administrative & support | 2025 |
| Skem Express Couriers Ltd | Transport & logistics | 2026 |
| Skem Settle Cars Limited | Administrative & support | 2013 |
| Skem Skip Hire Ltd | Extraterritorial | 2016 |
| Skem Truck Parking Limited | Transport & logistics | 2025 |