| Delta Scaffold Ltd | Construction | 2023 |
| Delta Services (Sheffield) Limited | Construction | 2006 |
| Delta Star Communications Limited | Information & communication | 2005 |
| Delta T Heating Solutions Limited | Construction | 2025 |
| Deltapropservices Ltd | Wholesale & retail | 2019 |
| Deluxe Loyal Ltd | Transport & logistics | 2025 |
| Deluxe Tableware Ltd | Wholesale & retail | 2015 |
| Delwes Consultancy Limited | Public administration | 2020 |
| DEM Systems UK Ltd | Information & communication | 2024 |
| Demaga Logistics Ltd | Transport & logistics | 2019 |
| Demand Technologies Limited | Information & communication | 2025 |
| Dementia Dreammakers Ltd | Professional & scientific | 2026 |
| Demhayal UK Limited | Wholesale & retail | 2007 |
| Demistone Properties Limited | Real estate | 2003 |
| Demon Wheelers Off-Road Leisure Limited | Administrative & support | 1996 |
| Demonstrandum Ltd | Information & communication | 2020 |
| Dempsey Court Management Limited | Households | 2017 |
| Demuth Consulting Limited | Professional & scientific | 2009 |
| Den's Deli Ltd | Hospitality | 2024 |
| Denaly Limited | Transport & logistics | 2019 |
| Denbar Installations Ltd | Construction | 2024 |
| Denby Investment Group Ltd | Real estate | 2022 |
| Denclad Installations Ltd | Construction | 2020 |
| Denden (GES) Limited | Real estate | 2021 |
| Denex Ltd | Professional & scientific | 2024 |
| Dengdev Properties Managment Limited | Real estate | 2025 |
| Dengro Limited | Information & communication | 2015 |
| Denisdrvie Ltd | Transport & logistics | 2019 |
| Denison Arms (East Ayton) Ltd | Hospitality | 2023 |
| Denken Ltd | Professional & scientific | 2016 |
| Denko Transport Limited | Transport & logistics | 2009 |
| Denkotech Limited | Construction | 2023 |
| Dennis Price Media Limited | Administrative & support | 2001 |
| Dental IT Ltd | Information & communication | 2006 |
| Dental Revive Ltd | Health & social care | 2025 |
| Dentech Developments Limited | Manufacturing | 2003 |
| Dentech Manufacturing Ltd | Real estate | 2024 |
| Dentforce Limited | Wholesale & retail | 2002 |
| Dentifab Ltd | Health & social care | 2021 |
| Dentil Limited | Wholesale & retail | 2011 |
| Dents HQ Limited | Wholesale & retail | 2025 |
| Denver Ltd | Real estate | 2022 |
| Denverlenne Health Care Ltd | Health & social care | 2025 |
| DEO Accountants Ltd | Professional & scientific | 2024 |
| DEO Financial Ltd | Professional & scientific | 2018 |
| Deoglamcollections Limited | Manufacturing | 2025 |
| Deone Cleaning Services Ltd | Administrative & support | 2025 |
| Dep-Home Rentals Ltd | Real estate | 2024 |
| Department Two Creative Ltd | Arts & recreation | 2017 |
| Depax Limited | Information & communication | 2014 |
| Derby Urology & Continence Services Limited | Health & social care | 2011 |
| Derbyshire Court Residents Limited | Households | 2017 |
| Derbyshire Fruit Company Limited | Extraterritorial | 1994 |
| Derbyshire Lane Fish Bar Limited | Hospitality | 2015 |
| Derbyshire Lane Services Ltd | Financial services | 2021 |
| Derbyshire Solar Ltd | Construction | 2023 |
| Derek Baldry Ministries Ltd | Education | 2021 |
| Derma Creative Limited | Manufacturing | 2024 |
| Derma Plus Medical Ltd | Health & social care | 2015 |
| Dermaform Medical Ltd | Health & social care | 2026 |
| Dermaglow Clinic Ltd | Administrative & support | 2022 |
| Dermal Science Ltd | Other services | 2022 |
| Dermaluxe Aesthetics Ltd | Health & social care | 2017 |
| Dermaluxe London Ltd | Manufacturing | 2025 |
| Dermaspa (London) Ltd | Health & social care | 2019 |
| Dermasphere Ltd | Health & social care | 2026 |
| Dermcap Ltd | Education | 2025 |
| Derry Hill Menston Management Company Limited | Households | 2021 |
| Dersim UK Ltd | Hospitality | 2024 |
| Derwent FLY Fishing Club Ltd | Arts & recreation | 2010 |
| Derwent Group Holdings Ltd | Financial services | 2024 |
| Derwent Joinery and Construction Ltd | Construction | 2018 |
| Derwent Recruitment Group Limited | Administrative & support | 2026 |
| DES Composites Limited | Professional & scientific | 2017 |
| DES Training and Consultancy Ltd | Information & communication | 2016 |
| Desert Limited | Professional & scientific | 1999 |
| Desi 2000 Ltd | Construction | 2019 |
| Desifuel Limited | Wholesale & retail | 2024 |
| Design ,Building Management Ltd | Construction | 2025 |
| Design Better Limited | Information & communication | 2026 |
| Design Castle Advertising Ltd | Professional & scientific | 2023 |
| Design DFD Ltd | Professional & scientific | 2025 |
| Design Floors (Sheffield) Limited | Extraterritorial | 2019 |
| Design Floors 1 Ltd | Wholesale & retail | 2008 |
| Design for Education Ltd | Information & communication | 2011 |
| Design Kiosk Limited | Information & communication | 2013 |
| Design Sprint Limited | Information & communication | 2017 |
| Design Sprint X Limited | Information & communication | 2023 |
| Design Webix Limited | Information & communication | 2025 |
| Design Workshop (UK) Limited | Manufacturing | 1999 |
| Design Workshop Fabrications Ltd | Manufacturing | 2015 |
| Design Yorkshire Ltd | Construction | 2023 |
| Design, Prototype, Manufacture and Supply Limited | Professional & scientific | 2009 |
| Designed Enterprises Ltd | Information & communication | 2012 |
| Designed to Build Ltd | Construction | 2019 |
| Designer Exteriors Limited | Manufacturing | 2020 |
| Designer Furniture Outlet Limited | Wholesale & retail | 2024 |
| Designer Kasbah Limited | Manufacturing | 1993 |
| Designer Kitchen Direct (Harrogate) Limited | Manufacturing | 2022 |
| Designer Pave Limited | Administrative & support | 2025 |