| Speck Plumbing and Heating Ltd | Construction | 2015 |
| Speed Trans Solution Ltd | Transport & logistics | 2018 |
| Spen Valley Scenery Ltd | Construction | 2016 |
| Spice of Bengal Selby Ltd | Hospitality | 2025 |
| SPM Construction Limited | Other services | 2019 |
| Sport Legacy Consultancy Limited | Professional & scientific | 2024 |
| Sport Legacy Group Limited | Professional & scientific | 2021 |
| Sporty Spirits Ltd | Hospitality | 2024 |
| Spray Trucks Limited | Manufacturing | 2017 |
| Sqes Limited | Professional & scientific | 2004 |
| St-Nectans Glen Ltd | Arts & recreation | 2016 |
| Stag and BOY Limited | Other services | 2015 |
| Stagexstudios Ltd | Professional & scientific | 2025 |
| Stamp House Properties Ltd | Real estate | 2020 |
| Stanleys Entertainments Ltd | Hospitality | 2019 |
| Star 6930 Limited | Hospitality | 2021 |
| Star TM Ltd | Construction | 2023 |
| Starfish Living Limited | Extraterritorial | 2018 |
| Stars Cars & Bars Ltd | Professional & scientific | 2024 |
| Station Road Motorcycles Limited | Arts & recreation | 2016 |
| Station Specialist Cars Ltd | Wholesale & retail | 2020 |
| Staynor Hall Community Centre Bars Limited | Hospitality | 2025 |
| STC Research Foundation | Agriculture & fishing | 2004 |
| Steam Property Management Ltd | Real estate | 2017 |
| Steloona Limited | Wholesale & retail | 2010 |
| Step UP Consulting Limited | Professional & scientific | 2018 |
| Stephen Greenwood Ltd | Professional & scientific | 2019 |
| Stephenson Brown Surfacing (Commercial) Ltd | Administrative & support | 2025 |
| Stephenson Brown Surfacing Ltd | Administrative & support | 2025 |
| Steworth Properties Ltd | Real estate | 2023 |
| Stingray Design Limited | Extraterritorial | 2016 |
| Stockbridge House Service Company Limited | Households | 2002 |
| Stockbridge Technology Centre Limited | Agriculture & fishing | 2001 |
| Stockpen Supplies Ltd | Wholesale & retail | 2025 |
| Stod Fold Events Ltd. | Hospitality | 2022 |
| Stonehouse Construction (Yorks) Ltd | Construction | 2006 |
| Stop 'N' Shop (Selby) Ltd | Wholesale & retail | 2022 |
| Storytellr Media Ltd | Information & communication | 2020 |
| Strands Services Limited | Information & communication | 2024 |
| Stravex Partners Ltd | Administrative & support | 2024 |
| Strawberry Fields Forever (York) Limited | Hospitality | 2022 |
| Street Social Selby Ltd | Hospitality | 2025 |
| Streetscape (Products & Services) Limited | Manufacturing | 2006 |
| Stress Contracts Ltd | Construction | 2021 |
| Stronach Contract Management Ltd | Professional & scientific | 2017 |
| Stuart Mcclintock Limited | Other services | 2018 |
| Studio Lester Limited | Information & communication | 2018 |
| SUM Workwear Limited | Manufacturing | 2022 |
| Sun Magic Limited | Other services | 2015 |
| Sundial Training Resources Ltd | Administrative & support | 2023 |
| Sunflower Energy Supply Limited | Energy | 2015 |
| Sunflower Social Work Ltd | Health & social care | 2025 |
| Supermenopause Limited | Professional & scientific | 2004 |
| Supreme Yorkshire Windows Ltd | Construction | 2024 |
| Swat Security (Selby) Limited | Administrative & support | 2025 |
| Swift Bookkeeping Ltd | Professional & scientific | 2012 |
| Swift Construction Yorkshire Ltd | Construction | 2026 |
| Switch Power Connections Ltd | Construction | 2024 |
| SYG Film Productions Limited | Information & communication | 2023 |
| Synergy Care Services Ltd | Public administration | 2022 |
| Synergy Construction Yorkshire Ltd | Construction | 2026 |
| T & P Building Services Limited | Construction | 2007 |
| T a D Electrics UK Limited | Manufacturing | 2016 |
| TAG2M Ltd | Professional & scientific | 2025 |
| Talking Tatties Limited | Agriculture & fishing | 2008 |
| Tall Trees Leisure Ltd | Professional & scientific | 2024 |
| Taperell Environmental Limited | Water & waste | 2016 |
| Taphill Studios Limited | Information & communication | 2009 |
| Tappr Limited | Information & communication | 2025 |
| Tartarus Labs Ltd | Information & communication | 2024 |
| Taylor Caravans Ltd | Wholesale & retail | 2016 |
| Taylor Farms (Cawood) Limited | Agriculture & fishing | 1997 |
| TBN Business Solutions Limited | Professional & scientific | 2023 |
| TCC - the Cleaning Company Limited | Administrative & support | 2013 |
| TCH Traffic Ltd | Construction | 2023 |
| Team AV Ltd | Professional & scientific | 2023 |
| Techeng Ltd | Professional & scientific | 2012 |
| Technical Stage Services Limited | Arts & recreation | 2003 |
| Technology Repairs Yorkshire Limited | Other services | 2023 |
| Techstorm Ltd | Manufacturing | 2023 |
| TED T Construction Ltd | Construction | 2020 |
| TEE Box Catering Ltd | Hospitality | 2019 |
| Telanex Ltd | Information & communication | 2016 |
| Telecommunications Electrical Surveying Services Group Ltd | Construction | 2023 |
| Thai Sunshine Ltd | Hospitality | 2022 |
| That Good Night Limited | Information & communication | 2014 |
| THE Abbots Hotel Ltd | Hospitality | 2023 |
| THE ALL Clear EAR Company Ltd | Health & social care | 2024 |
| THE Architect Design Studio Ltd | Professional & scientific | 2016 |
| THE Attic Hair & Beauty Ltd | Other services | 2019 |
| THE Baler MAN Ltd | Manufacturing | 2023 |
| THE Beautiful Splint Company CIC | Manufacturing | 2009 |
| THE Big Orange Catering Company Limited | Hospitality | 2022 |
| THE Brayton Bonanza CIC | Arts & recreation | 2026 |
| THE British Historic Kart Club Limited | Arts & recreation | 2010 |
| THE Burner Mining Company Limited | Information & communication | 2024 |
| THE Capri Restaurant Limited | Hospitality | 2009 |
| THE Car MAN Garage Ltd | Wholesale & retail | 2025 |
| THE Churchill (Selby) Ltd | Hospitality | 2019 |
| THE Club Productions Limited | Information & communication | 2017 |