| Springheal Physio Ltd | Health & social care | 2024 |
| Springthorpe's Developments Ltd | Construction | 2025 |
| Spyro Global Ltd | Professional & scientific | 2024 |
| Squeeky Clean (Scarborough) Limited | Administrative & support | 2020 |
| Squeeky Clean Scarborough Homeless Awareness & Community Support CIC | Administrative & support | 2026 |
| Sree Retail Ltd | Wholesale & retail | 2026 |
| Srel (TC) Ltd | Real estate | 2018 |
| SRI Vinayagar Ltd | Wholesale & retail | 2024 |
| Srrr Holdings Ltd | Financial services | 2021 |
| Srufc Silver Royd Limited | Arts & recreation | 2016 |
| ST Athanasius Farm Limited | Agriculture & fishing | 2016 |
| ST Cecilia's Care Contracts Limited | Administrative & support | 2022 |
| ST James Place Property Ltd | Real estate | 2016 |
| ST Martin's Trading CIC | Hospitality | 2024 |
| ST Martins Lodge Limited | Hospitality | 2015 |
| ST Peter's Yard (Norton) Management Company Limited | Real estate | 2014 |
| ST. Cecilia's Care Services Limited | Health & social care | 2000 |
| ST. Helens in the Park Limited | Hospitality | 1975 |
| ST. John's (Whitby) Management Limited | Households | 2006 |
| Stained Glass Centre Limited | Wholesale & retail | 2012 |
| Stanal Property Ltd | Real estate | 2025 |
| Stanel SRL Limited | Transport & logistics | 2025 |
| Stantarrah African Shop Ltd | Wholesale & retail | 2025 |
| Star Properties (Scarborough) Limited | Real estate | 2022 |
| Starters and Sweets Limited | Hospitality | 1991 |
| Startup Solutions Hub Ltd | Administrative & support | 2024 |
| Static Jetwashing Ltd | Administrative & support | 2020 |
| Stav Ortho Ltd | Health & social care | 2020 |
| Stay Current Electrical Services Limited | Construction | 2014 |
| Stay Independent at Home Scarborough Limited | Health & social care | 2019 |
| Stay-In Ready Homes Ltd | Real estate | 2026 |
| Stephen Joseph Theatre Enterprises Limited | Arts & recreation | 1990 |
| Stephenson Electrical Installations Limited | Construction | 2019 |
| Stepney Hill Farm Limited | Wholesale & retail | 2013 |
| Steve Goodchild Limited | Professional & scientific | 2012 |
| Steve Middleton Plumbing & Heating Limited | Construction | 2019 |
| Steve the Handyman Ltd | Manufacturing | 2020 |
| Steve's Aquatic Pet Emporium Ltd | Wholesale & retail | 2016 |
| Steven Norris Joinery & Developments Ltd | Manufacturing | 2023 |
| Steven Veart Limited | Agriculture & fishing | 2009 |
| Stewart Peckitt Ltd | Agriculture & fishing | 2006 |
| STI Flows Ltd | Wholesale & retail | 2026 |
| STI GB Limited | Manufacturing | 2005 |
| Stirling Real Estate Limited | Real estate | 2012 |
| Stittenham Estates Limited | Agriculture & fishing | 2018 |
| Stittenham Farms | Agriculture & fishing | 1972 |
| Stittenham Racing | Other services | 2011 |
| Stockills Limited | Construction | 2018 |
| Stonivale Limited | Manufacturing | 2012 |
| Stop and Go Snacks Ltd | Hospitality | 2023 |
| Storey Leisure Holdings Limited | Hospitality | 2017 |
| Storsense Ltd | Information & communication | 2025 |
| Stratford Promotions Limited | Administrative & support | 2026 |
| Stratum Rural Ltd | Real estate | 2025 |
| Stuart Booth Sound Limited | Manufacturing | 2023 |
| Studio 3 (Scarborough) Ltd | Arts & recreation | 2020 |
| Studioexcel Ltd | Information & communication | 2016 |
| Style Technique Limited | Construction | 2018 |
| SUB Aqua Diving Services (UK) Ltd | Professional & scientific | 2007 |
| Subway Southwest Ltd | Hospitality | 2023 |
| Summerdale Apartments Scarborough Ltd | Households | 2025 |
| Summitrealty Ltd | Real estate | 2024 |
| Sumo Properties Limited | Hospitality | 2020 |
| Sunbelt Spas Limited | Wholesale & retail | 2015 |
| Sundowner Life Limited | Information & communication | 2025 |
| Sunflower Cafe Scarborough Ltd | Hospitality | 2025 |
| Sunny Side Holdings NW Limited | Construction | 2017 |
| Sunset Wines Limited | Wholesale & retail | 2000 |
| Super Swim Academy Limited | Other services | 2011 |
| Superior Office Supplies Limited | Wholesale & retail | 2016 |
| Supporting Choice Ltd | Education | 2018 |
| Supreme Plumbing and Heating Services Ltd | Construction | 2021 |
| Surecase Technologies Limited | Financial services | 2019 |
| Surefire Imaging Ltd | Professional & scientific | 2014 |
| Surefire Supplies Ltd | Professional & scientific | 2014 |
| Surf Haven CIC | Education | 2021 |
| Sutton Shellfish Limited | Agriculture & fishing | 2022 |
| SVN Retail Ltd | Wholesale & retail | 2022 |
| SW Scarth Limited | Arts & recreation | 2024 |
| Swallow Haulage Limited | Transport & logistics | 2021 |
| Swanzdale Limited | Professional & scientific | 2003 |
| SWC Trade Frames Limited | Manufacturing | 2016 |
| Sweeting Engineers Limited | Professional & scientific | 2003 |
| Sweeting Investment Co Ltd | Financial services | 2011 |
| Swhaleys Ltd | Hospitality | 2025 |
| Swift Core Force Limited | Information & communication | 2025 |
| Swift Handyman Ltd | Construction | 2024 |
| Swift HR & Legal Ltd | Professional & scientific | 2015 |
| Swim NOW Leeds Ltd | Education | 2018 |
| Swim NOW Manchester Ltd | Education | 2018 |
| Swim NOW Scarborough Ltd | Education | 2020 |
| Swords and Pistols Limited | Administrative & support | 2012 |
| Sycamore Commercial Consulting Ltd | Professional & scientific | 2026 |
| Sycamore Farm West Lutton Limited | Construction | 2025 |
| Sylvern House Ltd | Hospitality | 2023 |
| SYM Motors Limited | Wholesale & retail | 2025 |
| Synthesys Compliance Consultancy Limited | Professional & scientific | 2021 |
| T & a Flooring Ltd | Wholesale & retail | 2014 |
| T Craven Training Ltd | Education | 2019 |
| T E & Daughters Ltd | Hospitality | 2016 |