| Shaw's Trailer Park Investments | Financial services | 2024 |
| Sheader Property Management Ltd | Real estate | 2022 |
| Shepherdson Properties Limited | Real estate | 2017 |
| Ship Rslc Ltd | Hospitality | 2024 |
| Shires Holdings (North Yorkshire) Limited | Financial services | 2025 |
| Shoeniquee Ltd | Wholesale & retail | 2021 |
| Shona's Hair Studio Limited | Other services | 2003 |
| Shoreline Property (Scarborough) Limited | Real estate | 2023 |
| Shoreline Suncruiser Buses Ltd | Transport & logistics | 1992 |
| Showkoi Limited | Manufacturing | 2009 |
| Siam Consultants Ltd | Information & communication | 2017 |
| Sica Properties Ltd | Real estate | 2023 |
| Sidewinder Watches Ltd | Wholesale & retail | 2020 |
| Sightline Performance Limited | Arts & recreation | 2012 |
| Signature Renovations and Developments Ltd | Construction | 2021 |
| Siksilk Ltd | Extraterritorial | 2023 |
| Silene Botanica Ltd | Manufacturing | 2025 |
| Silkyharry Projects Limited | Other services | 2024 |
| Silver Tree Estate Agents Ltd | Real estate | 2024 |
| Simply Relaxed Golf CIC | Other services | 2026 |
| Simply Yorkshire Limited | Real estate | 2013 |
| Simpson & Mclean Limited | Other services | 2019 |
| Simpson and Hill Construction Ltd | Construction | 2018 |
| Sinco Limited | Manufacturing | 2002 |
| Singlesignon Limited | Information & communication | 2012 |
| Siniprop Ltd | Real estate | 2023 |
| Siriwardana (Holding) Ltd | Professional & scientific | 2019 |
| Sisu by the Sea Ltd | Hospitality | 2025 |
| Sivas (Pickering) Limited | Hospitality | 2013 |
| Sixty Five Newborough Management Company Limited | Administrative & support | 2005 |
| SJ Ashfield Enterprises Limited | Real estate | 2025 |
| SJC Holdings Limited | Financial services | 2023 |
| SJD Services and Access Ltd | Construction | 2026 |
| SK Utility Contractors Ltd | Construction | 2005 |
| Skapandi Ltd | Professional & scientific | 2012 |
| Skarthborg Estates LLP | | 2020 |
| Skarthborg Limited | Real estate | 2019 |
| Skarthi - Relations Ltd | Professional & scientific | 2024 |
| SKH Engineering Ltd | Manufacturing | 2025 |
| Skids 4 Kids Limited | Health & social care | 2011 |
| SKILLS2SAVE.UK Limited | Education | 2017 |
| Skillswithlils CIC | Hospitality | 2025 |
| Skin Element Ltd | Health & social care | 2022 |
| Skindune Limited | Wholesale & retail | 2022 |
| SKP Business Services Ltd | Hospitality | 2010 |
| Sky Video Ltd | Information & communication | 2023 |
| Skyhighcleaning Scarborough Ltd | Water & waste | 2026 |
| Skyline Property Surveys Ltd | Construction | 2022 |
| SL23 Ltd | Construction | 2023 |
| Slate Marcus Ltd | Real estate | 2021 |
| Slate Marcus OM Ltd | Wholesale & retail | 2025 |
| Sleaford Picture Palace Limited(The) | Hospitality | 1920 |
| Slickbricks Ltd | Construction | 2025 |
| Slingsby Management Company (North Yorkshire) Limited | Households | 2025 |
| Smailes Goldie Watson Limited | Professional & scientific | 2022 |
| Smart Build Building & Civils Limited | Construction | 2016 |
| Smart House Clearance's Limited | Water & waste | 2023 |
| Smart Solutions (Yorkshire) Limited | Wholesale & retail | 2003 |
| Smart Wetrooms & Bathrooms Ltd | Construction | 2021 |
| Smart-Print Supplies Limited | Wholesale & retail | 2014 |
| Smith & Fowler LLP | | 2024 |
| Smith & Prentice Limited | Construction | 2002 |
| Smith Properties (Scarborough) Limited | Real estate | 2022 |
| Smiths Retail 2024 Limited | Wholesale & retail | 2024 |
| Smoothflo Academy Ltd | Wholesale & retail | 2023 |
| Snainton Fish & Chips Limited | Hospitality | 2023 |
| Sneakytrick Holdings Ltd | Information & communication | 2019 |
| Snowdonia Welsh Gold Limited | Manufacturing | 2015 |
| SNR Noise Consultants Ltd | Professional & scientific | 2024 |
| Social Current Ltd | Professional & scientific | 2026 |
| Social Storyboard Ltd | Professional & scientific | 2025 |
| Society Records Ltd. | Manufacturing | 2015 |
| Soft Base Computing Limited | Information & communication | 1992 |
| Softlock Pictures Ltd | Information & communication | 2025 |
| Solaceai Ltd | Information & communication | 2026 |
| Sole Care Podiatry Ltd | Health & social care | 2015 |
| Soluations Pro Ltd | Information & communication | 2025 |
| SOLUTIONS4U Limited | Professional & scientific | 2022 |
| Sonic Engineering & Oilfield Services Ltd | Construction | 2025 |
| Sons of Neptune Limited | Professional & scientific | 1986 |
| South Street Management Company (Scarborough) Limited | Households | 1991 |
| Southfield PIG Farms (Flixton) Limited | Agriculture & fishing | 1962 |
| Southside Apartments (Management) Limited | Households | 2007 |
| Southwold (Driffield) Limited | Real estate | 1997 |
| SP Plumbing Limited | Construction | 2016 |
| Spartan Solutions Engineering Ltd | Professional & scientific | 2025 |
| Spasafe U.K. Limited | Extraterritorial | 2012 |
| Spats Bar Ltd | Hospitality | 2024 |
| Speakers in Command Limited | Professional & scientific | 2010 |
| Specialised Automotive Limited | Real estate | 1997 |
| Specialist Medical Opinions Ltd | Health & social care | 2025 |
| Spectrum Cleaning Solutions Limited | Wholesale & retail | 2003 |
| Speed (Storage & Handling) Limited | Real estate | 1964 |
| Spice Chasers Ltd | Hospitality | 2026 |
| Spice Gallery Limited | Wholesale & retail | 2025 |
| Spike's Hideout Ltd | Wholesale & retail | 2024 |
| Spny Ltd | Construction | 2024 |
| Sportsphoto Ltd. | Manufacturing | 1997 |
| Spotless Cleaning Ltd | Administrative & support | 2024 |
| Springfield Property & Investments Ltd | Real estate | 2025 |