| DMA Solutions Limited | Administrative & support | 2015 |
| DMP Property Ltd | Real estate | 2022 |
| DNC Scaffolding (Yorkshire) Limited | Construction | 2017 |
| Dobson & Delve Developments Limited | Construction | 2020 |
| Dobson's Garden Machinery Limited | Wholesale & retail | 2005 |
| DON French Signs Ltd | Professional & scientific | 2014 |
| Donaa Limited | Information & communication | 2020 |
| Donna Peters Limited | Administrative & support | 2017 |
| Dorstep JON Ltd | Real estate | 2024 |
| Double OR Quits Limited | Professional & scientific | 2023 |
| Doubtfire Creative CIC | Arts & recreation | 2026 |
| Doughty Architectural Ltd | Professional & scientific | 2003 |
| Downcliffe House Management Company Limited | Households | 2023 |
| DP Engineering (Yorkshire) Limited | Construction | 2011 |
| DPR Home & Building Maintenance Limited | Construction | 2012 |
| DR AMY Adilih Limited | Real estate | 2022 |
| DR Dose Ltd | Public administration | 2025 |
| Draft Associates Limited | Professional & scientific | 2023 |
| Dragon Property Limited | Real estate | 2021 |
| Drawing Design Solutions Ltd | Professional & scientific | 2013 |
| Driveways of Scarborough Ltd | Extraterritorial | 2022 |
| DRL Info SY Limited | Administrative & support | 2018 |
| Drtdp Ltd | Health & social care | 2018 |
| DSE Scarborough Limited | Real estate | 2002 |
| DSM Solar Shading Solutions Limited | Manufacturing | 2020 |
| Duas Consultancy Limited | Health & social care | 2010 |
| Duggleby Holdings Limited | Financial services | 2018 |
| Duggleby Movers & Storers Ltd | Transport & logistics | 1960 |
| Duley GAS Services Ltd | Construction | 2020 |
| Duraweld Limited | Manufacturing | 2009 |
| Durrant Moore Associates Limited | Professional & scientific | 2001 |
| DW Motorcycles Ltd | Wholesale & retail | 2009 |
| Dymond Cleaning Services Ltd | Other services | 2020 |
| Dyson Coffee Consulting Limited | Hospitality | 2019 |
| E & J (Yorkshire) Ltd | Real estate | 2018 |
| E & S Smart Ltd | Professional & scientific | 2018 |
| E a Tyson and Sons Ltd | Agriculture & fishing | 2026 |
| E&J 2 (Yorkshire) Ltd | Real estate | 2021 |
| E.M.C.E. Limited | Construction | 1995 |
| Eadweard Holdings Limited | Professional & scientific | 2025 |
| Earth Folk Ltd | Professional & scientific | 2023 |
| Earthloom - Premium Cotton Tees Ltd | Wholesale & retail | 2026 |
| Easby Hall Management Company Limited | Households | 2003 |
| East Ayton Accountancy Limited | Professional & scientific | 2011 |
| East Coast Bearings Limited | Wholesale & retail | 2005 |
| East Coast Building Management (Bridlington) Ltd | Real estate | 2018 |
| East Coast Building Management (Skegness) Ltd | Real estate | 2017 |
| East Coast Building Management (the Crescent 2) Ltd | Real estate | 2018 |
| East Coast Car Keys Limited | Other services | 2024 |
| East Coast Consultant Limited | Administrative & support | 2026 |
| East Coast Developments (Yorkshire) Limited | Real estate | 2007 |
| East Coast E-Cigs Ltd | Wholesale & retail | 2015 |
| East Coast Fire Services Limited | Other services | 2000 |
| East Coast Pest Control Trustees Limited | Administrative & support | 2021 |
| East Coast Skate Academy C.I.C. | Education | 2024 |
| East Coastal Hospitality Ltd | Hospitality | 2024 |
| East European Mini Market Ltd | Wholesale & retail | 2026 |
| East Grinstead Tennis Coaching Ltd | Arts & recreation | 2013 |
| East Pier Waffle Shop Limited | Hospitality | 2023 |
| Eastborough Convenience Store Ltd | Wholesale & retail | 2026 |
| Eastborough Management Limited | Extraterritorial | 1995 |
| Eastbury House (Whitby) Limited | Households | 1989 |
| Eastern European Mini Market Ltd | Wholesale & retail | 2024 |
| Eastgate Coach Trimmers Limited | Wholesale & retail | 2005 |
| Eastgate Fisheries Limited | Hospitality | 2016 |
| Eastpro Farms Limited | Agriculture & fishing | 2021 |
| Eastpro Limited | Other services | 2005 |
| Eastway Store Scarborough Ltd | Wholesale & retail | 2013 |
| EAT ME Boys Ltd | Hospitality | 2021 |
| Eazzee Building Maintenance Ltd | Construction | 2020 |
| Ebor Properties Limited | Real estate | 2012 |
| Echelon S&S Estates Ltd | Real estate | 2026 |
| Ecommerce Stock Platform Limited | Information & communication | 2023 |
| Ecsf Ltd | Education | 2015 |
| Ecsh Limited | Information & communication | 2018 |
| Ecura Learn Limited | Education | 2025 |
| Eddie Preston Building & Joinery Limited | Construction | 2015 |
| Edgewood Scarborough Management Company Limited | Households | 2003 |
| Edtech Nexus Ltd | Professional & scientific | 2024 |
| Edward Milnes Accountancy Ltd | Professional & scientific | 2015 |
| Edwards Estates (Scarborough) Limited | Real estate | 2012 |
| Edwin Jenkinson Limited | Manufacturing | 2005 |
| Egton Weir Ltd | Financial services | 2018 |
| Eiko Networks Ltd | Information & communication | 2025 |
| Eikon Motors Ltd | Manufacturing | 2025 |
| EJ Retail Ltd | Wholesale & retail | 2026 |
| EJH Training Services Ltd | Health & social care | 2015 |
| EL Loco Gnome Ltd | Wholesale & retail | 2021 |
| Elaruvi Ltd | Education | 2026 |
| Elavated Views Limited | Construction | 2025 |
| Elaw Conveyancing Ltd | Other services | 2022 |
| Elcab Ltd | Transport & logistics | 2026 |
| Eleanor Property Ltd | Real estate | 2022 |
| Elect-Rick Installation and Testing Limited | Construction | 2013 |
| Electric Angel Design LLP | | 2008 |
| Electro Mechanical Services (UK) Limited | Manufacturing | 2011 |
| Electrodec Limited | Construction | 1999 |
| Electrodiesels Limited | Manufacturing | 1975 |
| Eliam Bros Ltd | Hospitality | 2020 |
| Elite Strength & Fitness (Yorkshire) Ltd | Arts & recreation | 2025 |