| R & R Williams Limited | Transport & logistics | 2006 |
| R a Mellor Accountancy Services Limited | Professional & scientific | 2026 |
| R a Mellor Limited | Professional & scientific | 2003 |
| R B Energy Consultants Ltd | Professional & scientific | 2023 |
| R Gent Consultancy Limited | Administrative & support | 2009 |
| R Lowden and Co Ltd | Professional & scientific | 2016 |
| R M & J Smith Limited | Manufacturing | 2003 |
| R S Plumbing & Heating (UK) Ltd | Construction | 2008 |
| R&M Professional Services Ltd | Professional & scientific | 2025 |
| R&S Contract Cleaning Ltd | Administrative & support | 2023 |
| Rachel Urquhart HR Limited | Professional & scientific | 2017 |
| Radajord Limited | Real estate | 2022 |
| RAJ Property Partnership LLP | | 2024 |
| Rallye Ventures Ltd | Financial services | 2012 |
| Randles Farriers Limited | Administrative & support | 2015 |
| Rapp Regulatory Ltd | Professional & scientific | 2022 |
| Rappell LV Limited | Professional & scientific | 2009 |
| Rappell Switchgear Limited | Extraterritorial | 2009 |
| Ravenware Limited | Information & communication | 2016 |
| RAW Developments Ltd | Real estate | 2014 |
| Rcfe Medical Ltd | Health & social care | 2022 |
| Realtor Limited | Extraterritorial | 1990 |
| Redburne Landscape Developments Limited | Construction | 2013 |
| Redz Properties Limited | Real estate | 2026 |
| Reilly Psychology Ltd | Health & social care | 2021 |
| Rejoice and BE Clad Limited | Construction | 2007 |
| REM Projects UK Limited | Administrative & support | 2025 |
| Remagination Ltd | Construction | 2018 |
| Renaissance Dance Theatre Ltd | Arts & recreation | 2017 |
| Rest Easy Training Ltd | Information & communication | 2019 |
| Retro Coatings Ltd | Other services | 2014 |
| Retroryder Ltd | Wholesale & retail | 2025 |
| RF Business Consulting Ltd | Professional & scientific | 2023 |
| RGC Financial Limited | Financial services | 2016 |
| Rhino Safety Limited | Other services | 2015 |
| Rhino Sensory UK Limited | Manufacturing | 2017 |
| Rhodes Mechanical Limited | Construction | 2022 |
| Richardson Farms Holdings Limited | Financial services | 2025 |
| Richardson Farms Limited | Agriculture & fishing | 2022 |
| Riddings IT Ltd | Information & communication | 2014 |
| RIE Ventures Ltd | Real estate | 2021 |
| RIG Developments Ltd | Construction | 2020 |
| RIG Eastgate Ltd | Real estate | 2022 |
| Rightpay Solutions 2024 Limited | Health & social care | 2024 |
| Rise & Shine Cheshire Limited | Administrative & support | 2026 |
| Riverbank Holdings Limited | Professional & scientific | 2020 |
| Riverdon Rentals Limited | Real estate | 2021 |
| Rivington Property Company Limited | Real estate | 2005 |
| RJ and AS Consultancy Services Ltd | Extraterritorial | 2024 |
| RJH Business Solutions Limited | Professional & scientific | 2025 |
| RJS Electrical (Cheshire) Ltd | Construction | 2025 |
| RK Civils and Construction Limited | Construction | 2025 |
| RM Hair Ltd | Other services | 2014 |
| RM Rail Limited | Professional & scientific | 2022 |
| RMC Energy Services Limited | Administrative & support | 2002 |
| RNC Estates Ltd | Real estate | 2025 |
| Robert Frederick HAY Ltd | Wholesale & retail | 2019 |
| Robert Richardson Videography Ltd | Information & communication | 2019 |
| Roberts Holdings Limited | Professional & scientific | 2016 |
| Robeth Ltd | Financial services | 2014 |
| Robsco Industries Ltd | Information & communication | 2017 |
| Rocket Reach PPC Ltd | Professional & scientific | 2025 |
| Rocketboosters Ltd | Information & communication | 2023 |
| Rohanpharma Ltd | Wholesale & retail | 2018 |
| Rojeeka Limited | Wholesale & retail | 2024 |
| Rookery Stay Group Ltd | Real estate | 2025 |
| Rorobot Ltd | Information & communication | 2023 |
| Rose & Crown Congleton Limited | Real estate | 2015 |
| Rose Blossom Hair Boutique Limited | Real estate | 2020 |
| Rosenberg Process Technology Ltd | Professional & scientific | 2016 |
| Rtlc Ltd | Information & communication | 2012 |
| Ruby Ceramics Limited | Construction | 2012 |
| Ruby TUE Ltd | Wholesale & retail | 2020 |
| Rulebridge Consulting Limited | Professional & scientific | 2024 |
| Runnorthwales Ltd | Other services | 2017 |
| Rushcroft Education Ltd | Education | 2026 |
| Rushcroft Investments Ltd | Information & communication | 2026 |
| Russell Grant Astrology Limited | Arts & recreation | 1984 |
| Ruth Carney Limited | Arts & recreation | 2011 |
| Ruth Jenkins Consultancy Limited | Education | 2009 |
| RW Project Support Ltd | Professional & scientific | 2023 |
| S D Graphic Design Ltd | Professional & scientific | 2024 |
| S J Tipper Hire Ltd | Construction | 2020 |
| S&S Andrew Limited | Households | 2022 |
| S-Craft Limited | Water & waste | 2015 |
| S.I. Construction Ltd. | Construction | 2016 |
| Safe Crane Equipment UK Limited | Other services | 2019 |
| Safe Storage Solutions Limited | Other services | 2019 |
| Safeside Property Maintenance Ltd | Construction | 2025 |
| Safesystems Water Services Limited | Water & waste | 2025 |
| Safety Training by Design Limited | Education | 2011 |
| Salco Ltd | Real estate | 2021 |
| Sand Medical Reporting Limited | Health & social care | 2025 |
| Sandbach Accident and Repair Centre Limited | Wholesale & retail | 2012 |
| Sandbach Agricultural Services Limited | Agriculture & fishing | 2013 |
| Sandbach Barbershop Ltd | Other services | 2025 |
| Sandbach Business Services Limited | Professional & scientific | 2012 |
| Sandbach Carpet Centre Ltd | Wholesale & retail | 2001 |
| Sandbach Chiropractic Clinic Limited | Health & social care | 2022 |
| Sandbach Commercial Dismantlers Limited | Wholesale & retail | 2002 |