| Shearwaters Consulting Ltd | Professional & scientific | 2025 |
| Shepherding Insights Ltd | Professional & scientific | 2025 |
| Shire Horse Centre Farm Limited | Arts & recreation | 2011 |
| Sigma Associates (Aerospace) Limited | Professional & scientific | 1998 |
| Silicone Composites Limited | Manufacturing | 2013 |
| Silverfish Group Holdings Limited | Professional & scientific | 2021 |
| Silverfish Holdings Limited | Professional & scientific | 2018 |
| Silverfish UK (Holdings) Limited | Wholesale & retail | 2011 |
| Silverfish UK Limited | Wholesale & retail | 2000 |
| Simper's Silver Harvest LLP | | 2016 |
| Simpl.Fy Ltd | Professional & scientific | 2025 |
| Sinclair Leadership Assessment Limited | Professional & scientific | 2020 |
| SIR Robert Geffery's School | Education | 2011 |
| SJ Southwest Developments Ltd | Administrative & support | 2017 |
| SK2 Games Limited | Information & communication | 2025 |
| Skeldons Ltd | Construction | 2024 |
| Slipway Quay Management Company Limited | Households | 1989 |
| SMG Garage Group Ltd | Manufacturing | 2019 |
| Software & Hardware Independent Traders Ltd | Information & communication | 2026 |
| Solutions by MEE Ltd | Professional & scientific | 2024 |
| SOMETHING2TRADE Limited | Wholesale & retail | 2019 |
| Sonnah Construction Limited | Construction | 2013 |
| Sound Estate Planning Ltd | Financial services | 2024 |
| South West Aquaculture CIC | Agriculture & fishing | 2024 |
| South West Shopfittings Limited | Wholesale & retail | 2007 |
| South West Signs Limited | Professional & scientific | 2009 |
| South West Solutions Ltd | Transport & logistics | 2020 |
| South West Surfacing Specialists Limited | Construction | 2010 |
| South West Tyre Recycling Ltd | Water & waste | 2020 |
| Southern Coaching Ltd | Arts & recreation | 2026 |
| Southern Horizons (UK) Ltd | Professional & scientific | 2012 |
| Southpoint Fire & Security Ltd | Administrative & support | 2025 |
| Southway Power Ltd | Real estate | 2018 |
| Southwest Car Imports Ltd | Administrative & support | 2019 |
| Southwest Remedials Ltd | Transport & logistics | 2021 |
| Space Design Architecture Limited | Professional & scientific | 2008 |
| Sparkle Squad South West Limited | Administrative & support | 2024 |
| Special CUT Barbers Ltd | Other services | 2025 |
| Specialist Skip Hire Limited | Water & waste | 2005 |
| Spectrum Floor-Site Ltd | Wholesale & retail | 2002 |
| Spencer-Richardson Limited | Administrative & support | 2020 |
| Spirited Clothes & Home Limited | Wholesale & retail | 2018 |
| Sports Brands Clearance Limited | Wholesale & retail | 2025 |
| SPR Construction Limited | Construction | 2015 |
| ST Francis Court (Plymouth) RTM Company Limited | Real estate | 2010 |
| ST Germans Priory | Arts & recreation | 2012 |
| Stafford House (Ilfracombe) Management Company Limited | Households | 1996 |
| Station Court Saltash Management Company Limited | Households | 2011 |
| Stax Properties Limited | Construction | 2010 |
| Stax Storage Limited | Administrative & support | 2009 |
| Step Exchange Limited | Financial services | 2017 |
| Stepex Lender Limited | Financial services | 2018 |
| Stepping Stones Properties South West Ltd | Real estate | 2026 |
| Steve Manuel Electrical Ltd | Construction | 2025 |
| STG Advisory Ltd | Professional & scientific | 2025 |
| Stockadon Farm Barns Management Company Limited | Households | 2005 |
| Stoke Damerel Limited | Households | 1990 |
| Stoketon Ltd | Extraterritorial | 2016 |
| Stone Craft Solutions Limited | Construction | 2023 |
| Streat Foods Ltd | Hospitality | 2013 |
| Strut Your Stuff Ltd | Wholesale & retail | 2025 |
| Sturtridge SW Ltd | Real estate | 2024 |
| Sugar Sleuth Ltd | Wholesale & retail | 2026 |
| Sullamon Holdings Limited | Financial services | 2022 |
| Summerfield Heating & Plumbing Limited | Construction | 2022 |
| Sumner Waller Productions Limited | Information & communication | 2025 |
| Sumoda Properties Limited | Real estate | 2022 |
| Sunrise Windows (Plymouth) Limited | Construction | 1999 |
| Surepass MCT 2021 Ltd | Education | 2021 |
| SW Media Holdings Ltd | Wholesale & retail | 2019 |
| SW Solar Limited | Construction | 2022 |
| SW Trade Frames Ltd | Construction | 2024 |
| Swtr (Wiltshire) Ltd | Water & waste | 2022 |
| Swyc Properties Ltd | Real estate | 2017 |
| Taboo Art Gallery Ltd | Other services | 2019 |
| Tack and Jibe Ltd | Wholesale & retail | 2024 |
| Take a Punt Co Limited | Extraterritorial | 2011 |
| Talland Management Services Limited | Administrative & support | 2008 |
| Talland Properties Limited | Real estate | 2012 |
| Tamar Agency Limited | Other services | 2025 |
| Tamar Construction Ltd | Construction | 2024 |
| Tamar Decorators Limited | Construction | 2012 |
| Tamar Distribution Ltd | Wholesale & retail | 2018 |
| Tamar Fresh Limited | Administrative & support | 2011 |
| Tamar House Nursing Home Limited | Health & social care | 2023 |
| Tamar Landscapes Ltd | Administrative & support | 2018 |
| Tamar Landscaping Supplies Ltd | Manufacturing | 2022 |
| Tamar Mobility Ltd | Manufacturing | 2018 |
| Tamar Protection Society | Arts & recreation | 1999 |
| Tamar Rehabilitation Engineering Services Limited | Health & social care | 2012 |
| Tamar Skills South West CIC | Education | 2017 |
| Tamar Trash Ltd | Water & waste | 2022 |
| Tamar View Fruiterers Ltd | Wholesale & retail | 2010 |
| Tavistock Hockey Club | Arts & recreation | 2010 |
| Taylor Rose (Contracting) Limited | Manufacturing | 2015 |
| Taylor Symes Ltd | Manufacturing | 2009 |
| Tbsa Parkhouse Ltd | Real estate | 2023 |
| Teambuild Group Limited | Administrative & support | 2024 |
| Teseke Limited | Financial services | 2021 |
| THE Admin Centre (SW) Ltd | Administrative & support | 2026 |