| Print by Design Limited | Manufacturing | 2002 |
| Printbridge Limited | Wholesale & retail | 2008 |
| Printed Ribbon Company Ltd | Wholesale & retail | 2018 |
| Pro-Mets Ltd | Wholesale & retail | 1998 |
| PRO4M Engineering Ltd | Administrative & support | 2017 |
| Project Management Penelewey Limited | Construction | 2016 |
| Project Management South West Limited | Real estate | 2010 |
| Projects SW Ltd. | Construction | 2024 |
| PROPERTIESSOURCED4U Ltd | Real estate | 2025 |
| Property Group SW Limited | Real estate | 2018 |
| Proven Winners Europe Limited | Wholesale & retail | 2002 |
| Psychoanalytica Community Interest Company | Information & communication | 2020 |
| Psychology Associates Limited | Health & social care | 2001 |
| Pure Discovery Limited | Arts & recreation | 2022 |
| Pure First Care Services Limited | Health & social care | 2023 |
| Pureleak Group Ltd | Water & waste | 2021 |
| Pureleak Ltd | Construction | 2018 |
| Purimo Ltd | Wholesale & retail | 2024 |
| PWA Capability Ltd | Professional & scientific | 2025 |
| Pwcr Ltd | Manufacturing | 2024 |
| Pyramid AV Limited | Administrative & support | 2022 |
| QAT Ltd | Real estate | 2025 |
| QAT Manco Ltd | Households | 2025 |
| Quantum Fire and Security Ltd | Administrative & support | 2025 |
| Quayside Fresh Ltd | Wholesale & retail | 2013 |
| Quickcom Ltd | Information & communication | 2020 |
| R & C Office Lettings Limited | Real estate | 2011 |
| R and L Lets Ltd | Real estate | 2022 |
| R.A.B. Plumbing & Heating Ltd | Construction | 2013 |
| Ragit Media Limited | Professional & scientific | 2019 |
| Rail Signalling and Power Holdings Limited | Financial services | 2023 |
| Rail Signalling and Power Limited | Manufacturing | 2017 |
| Ramalambadingdong Ltd | Extraterritorial | 2011 |
| Raven Property Maintenance Limited | Administrative & support | 2025 |
| Rawgis Limited | Information & communication | 2025 |
| RDC Advisory Limited | Administrative & support | 2024 |
| Reciprocity Ltd | Wholesale & retail | 2021 |
| Recycling Machinery Ltd | Manufacturing | 2025 |
| Reestart Recovery House CIC | Health & social care | 2010 |
| REK Kitchens and Bathrooms Ltd | Construction | 2024 |
| Renroh Ltd | Professional & scientific | 2024 |
| Retail Edge Marketing Limited | Information & communication | 2020 |
| Retrink Ltd | Other services | 2022 |
| RFC New Rodney Ltd | Hospitality | 2020 |
| Richard Gotham Building Services Ltd | Construction | 2023 |
| Richard Rowan Farms Ltd | Agriculture & fishing | 2017 |
| Richard Rowan Holdings Limited | Financial services | 2022 |
| Rights and Voice Alliance Limited | Professional & scientific | 2013 |
| Ringrose Property Ltd | Real estate | 2023 |
| Rise Energy South West Ltd | Construction | 2025 |
| Riverbank Cottages (Saltash) Management Company Limited | Professional & scientific | 1991 |
| RJ Complete Plumbing Ltd | Construction | 2023 |
| RJS Carpentry and Construction Ltd | Construction | 2023 |
| RJS South West Ltd | Construction | 2024 |
| RJV South West Ltd | Construction | 2024 |
| Roborough Building Services Ltd | Construction | 2012 |
| Roger Young Asset Management Ltd | Real estate | 2015 |
| Roger Young Limited | Wholesale & retail | 1987 |
| Rogers Blinds & Awnings Limited | Wholesale & retail | 1995 |
| Rogers Blinds Ltd | Manufacturing | 2006 |
| Romeo Echo Papa Ltd | Arts & recreation | 2017 |
| Roods Developments | | 1994 |
| Roods Environmental Services Limited | Water & waste | 1995 |
| Roods Group Limited | Professional & scientific | 2012 |
| Rose Construction (SW) Ltd | Construction | 2025 |
| Rowan & Edwards Limited | Professional & scientific | 2005 |
| RSA RAW Ltd | Construction | 2023 |
| RSD (Cardiff) Limited | Administrative & support | 2020 |
| RSD (Manchester) Limited | Administrative & support | 2020 |
| RSD Investing Company Limited | Financial services | 2019 |
| RSD Recruitment Limited | Administrative & support | 2015 |
| RSD Site Recruit Limited | Administrative & support | 2017 |
| RSD Talent Acquisitions Limited | Administrative & support | 2019 |
| RSD Topco Limited | Administrative & support | 2019 |
| S D Hardware Ltd | Wholesale & retail | 2014 |
| S M C Radiological Protection Limited | Professional & scientific | 2012 |
| SA Corp Limited | Hospitality | 2023 |
| Safesite (SW) Limited | Administrative & support | 2006 |
| Salt Arts CIC | Arts & recreation | 2023 |
| Saltash Bandits Ltd | Hospitality | 2022 |
| Saltash Barbers (SW) Limited | Other services | 2024 |
| Saltash Clouds Ltd | Wholesale & retail | 2025 |
| Saltash Red BUS Limited | Transport & logistics | 2025 |
| Saltash Regatta CIC | Arts & recreation | 2024 |
| Saltash Rugby Football Club Limited | Arts & recreation | 2022 |
| Saltash Smart Hand Car Wash Ltd | Administrative & support | 2023 |
| Saltash Smoke Point Ltd | Wholesale & retail | 2024 |
| Sasmen Ltd | Administrative & support | 2023 |
| Scape South West Ltd | Real estate | 2017 |
| Scents & Scentsibility Ltd | Wholesale & retail | 2018 |
| Scientiva Limited | Information & communication | 2002 |
| Scott Parry Associates Limited | Real estate | 2018 |
| Scram Group Limited | Financial services | 2020 |
| Secure Innovation Group Limited | Professional & scientific | 2010 |
| Secure Innovation Limited | Manufacturing | 1990 |
| Secure Store South West Ltd | Transport & logistics | 2023 |
| Self Build South West Limited | Real estate | 2016 |
| Sellick Industrial Units Ltd | Real estate | 2022 |
| Shaped Interiors Limited | Construction | 2008 |
| Shaun Libby Building Solutions Ltd | Construction | 2017 |