| DSG-B2B Ltd | Professional & scientific | 2020 |
| DSM Trans Ltd | Transport & logistics | 2021 |
| Dstop Limited | Wholesale & retail | 2019 |
| DSW Partners LLP | | 2024 |
| DTE Consultancy Ltd | Health & social care | 2014 |
| DTK Water Limited | Administrative & support | 2015 |
| DU Noir Ltd | Wholesale & retail | 2026 |
| Dualhaven Limited | Households | 1988 |
| Dublon Developments Ltd | Professional & scientific | 2018 |
| Ducasse Systems Ltd | Information & communication | 2007 |
| Dude Aerospace Ltd | Professional & scientific | 2023 |
| Dukes Meadow (Tangmere) Management Company Limited | Households | 2016 |
| Dunbeath Engineering Limited | Manufacturing | 1999 |
| Dunbeath Farms Limited | Agriculture & fishing | 1997 |
| Dunlop Consultants Ltd | Professional & scientific | 2025 |
| Dunmore Road Management Company Limited | Households | 2020 |
| Dunn (Salisbury) Limited | Financial services | 2024 |
| Dunraven Care Group Holdings Limited | Health & social care | 2024 |
| Dunraven Care Group Limited | Health & social care | 2024 |
| Duquesa Property Ltd | Real estate | 2015 |
| Durrington Plough Limited | Hospitality | 2019 |
| Dust Hole Ltd | Hospitality | 2025 |
| DW16 Motorsports Limited | Arts & recreation | 2022 |
| Dwhwd Ltd | Other services | 2024 |
| Dylan Biddle Entertainment Ltd | Arts & recreation | 2023 |
| Dyls Auto Parts Ltd | Wholesale & retail | 2026 |
| Dynamic Domain Limited | Information & communication | 2022 |
| Dynamite Scaffolding Limited | Construction | 2018 |
| Dyrham View Management Company Limited | Households | 2024 |
| DZ Solutions Limited | Information & communication | 2012 |
| E & E Design Services Ltd | Professional & scientific | 2013 |
| E & O Holdings Salisbury Limited | Financial services | 2023 |
| E & O Properties Salisbury Limited | Real estate | 2025 |
| E and H Property Limited | Real estate | 2019 |
| E C Technical Services Ltd | Construction | 2022 |
| E J C Groundworks Ltd | Construction | 2008 |
| E S R Services Limited | Wholesale & retail | 2002 |
| E Williams Plating Limited | Manufacturing | 2006 |
| E&D Collectibles Ltd | Wholesale & retail | 2026 |
| E-Zee Trend Limited | Wholesale & retail | 2001 |
| E. D. & W. Bodman Limited | Construction | 2006 |
| E. Neville Ltd. | Professional & scientific | 2008 |
| E.G.G. Technologies International Limited | Wholesale & retail | 1998 |
| E.J.L. Decorating Contractors Limited | Wholesale & retail | 1978 |
| Eagle Point Limited | Arts & recreation | 2014 |
| Earbash Ltd | Information & communication | 2006 |
| Earlsfield Park (Knowsley) Management Company Limited | Professional & scientific | 2019 |
| Earth Creative Strategies Limited | Administrative & support | 2010 |
| Earthly Biochar Ltd | Professional & scientific | 2018 |
| Earthly Collective CIC | Education | 2026 |
| Earthstreet Limited | Professional & scientific | 1982 |
| Eason Enterprise Limited | Wholesale & retail | 2018 |
| East Bros. (Holdings) Limited | Professional & scientific | 2001 |
| East Bros.(Timber)Limited | Agriculture & fishing | 1945 |
| East Gate House (Machynys East) Management Company Limited | Households | 2014 |
| East London OUT Project | Health & social care | 1997 |
| East ST Barbers Limited | Other services | 2023 |
| East Stoke Land Limited | Real estate | 2021 |
| Eastcourt & Westcourt (Netheravon) Limited | Households | 2009 |
| Eastern Approaches Consultancy Ltd | Information & communication | 2013 |
| Eastgate Property Development Limited | Hospitality | 2015 |
| Eastlong Property Limited | Real estate | 2022 |
| Easton House Management Company Limited | Households | 2002 |
| Easton Property Care Ltd | Construction | 2014 |
| Eastron Europe Limited | Manufacturing | 2017 |
| Easy Group Partnership Ltd | Other services | 2024 |
| Easy Split UK Ltd | Manufacturing | 2015 |
| Easypave Limited | Administrative & support | 2014 |
| EAT Stay Love Limited | Hospitality | 2024 |
| Eaton Crescent Management Company Limited | Households | 2016 |
| Eazy Peazy Ltd | Administrative & support | 2026 |
| Ebble Consulting Limited | Professional & scientific | 2019 |
| Ebble Developments Limited | Real estate | 1969 |
| Ebbleside Properties Limited | Real estate | 2006 |
| EBE Estates Limited | Real estate | 2023 |
| Ebene Limited | Hospitality | 2021 |
| Ebury Communications Ltd | Professional & scientific | 2017 |
| EC Forever Ltd | Other services | 2017 |
| EC Salisbury Ltd | Other services | 2016 |
| ECA Group Solutions Ltd | Wholesale & retail | 2020 |
| Ecclesden Park (Angmering) Management Company Limited | Households | 2021 |
| Echeveri Ltd | Professional & scientific | 2022 |
| Ecleen Ltd | Administrative & support | 2016 |
| Eclipse Detailing Limited | Wholesale & retail | 2020 |
| Eclipse Ecology Ltd | Professional & scientific | 2018 |
| Eco Assist Limited | Construction | 2012 |
| Eco Blasting Limited | Extraterritorial | 2016 |
| Eco Pond Limited | Wholesale & retail | 2006 |
| Ecrins Asset Management Limited | Professional & scientific | 2011 |
| ECS Climate Systems Limited | Construction | 2011 |
| ED Dibbles Ltd | Hospitality | 2026 |
| ED Knight Contracting Limited | Agriculture & fishing | 2005 |
| Edgeley Times Limited | Real estate | 2018 |
| Edgerton Riley Limited | Information & communication | 2018 |
| Edgley Design Limited | Professional & scientific | 2008 |
| Edison & Day Ltd | Manufacturing | 2018 |
| Editions Alecto Limited | Information & communication | 1962 |
| Edmar Properties Ltd | Manufacturing | 2026 |
| Edmb Limited | Hospitality | 2023 |
| Edson Healthcare Limited | Health & social care | 2015 |