| Dayfold Limited | Manufacturing | 1980 |
| Days EYE Ltd | Construction | 2025 |
| Days Farm Cattery Ltd | Extraterritorial | 2023 |
| Daytona Detailing Ltd | Wholesale & retail | 2024 |
| DB Interiors of Wiltshire Limited | Professional & scientific | 2017 |
| DB Landscaping & Fencing Ltd | Administrative & support | 2025 |
| DB Painting and Decorating Ltd | Construction | 2022 |
| DC Decor Ltd | Construction | 2019 |
| DC Independent Services Ltd | Health & social care | 2019 |
| DC Loft Boarding Ltd | Manufacturing | 2023 |
| DC TAXI4U Salisbury Ltd | Transport & logistics | 2023 |
| DCP Engineering Ltd | Professional & scientific | 2024 |
| DE Havilland Court Management Company Limited | Real estate | 2018 |
| DE Havilland Place (White Waltham) Management Company Limited | Households | 2025 |
| De-Mandeville Management Company Limited | Households | 2021 |
| Deacons Truck and Trailer Limited | Wholesale & retail | 2005 |
| Deals Bazaar Ltd | Wholesale & retail | 2023 |
| Dean Goddin Plumbing and Heating Limited | Administrative & support | 2017 |
| Dean Street Press Limited | Information & communication | 2023 |
| Deborah Bichener Limited | Construction | 2024 |
| Debunk Energy Ltd | Manufacturing | 2025 |
| DEC Hands Ltd | Construction | 2014 |
| Decatz Limited | Information & communication | 1997 |
| Deep Blue Health UK Limited | Wholesale & retail | 2014 |
| Deer Park Road (Edgbaston) Management Company Limited | Real estate | 2013 |
| Deerland Farm Ltd | Agriculture & fishing | 2024 |
| Deerleap Innovations Ltd | Information & communication | 2025 |
| Deeside (Garden City) Management Company Limited | Households | 2023 |
| Delayed Strike Technology Ltd | Manufacturing | 2013 |
| Delcom Systems Limited | Wholesale & retail | 2006 |
| Delegate ME Solutions Ltd | Administrative & support | 2025 |
| Delight Baker Limited | Manufacturing | 2026 |
| Delightful Gifts Ltd | Administrative & support | 2026 |
| Delivering Business Solutions Limited | Professional & scientific | 2014 |
| Delivery VIN Ltd | Wholesale & retail | 2022 |
| Dellshore Properties Limited | Households | 2021 |
| Delphi Systems Ltd | Information & communication | 2001 |
| Delphinus Scientific Ltd. | Professional & scientific | 1997 |
| Delta Sierra Aviation Limited | Professional & scientific | 2024 |
| Delta Strategies Limited | Professional & scientific | 2014 |
| Delta Tool Co Limited | Wholesale & retail | 2018 |
| Deltaplan Limited | Real estate | 2013 |
| Demand Hub UK Limited | Wholesale & retail | 2014 |
| Demi 95 Limited | Wholesale & retail | 2019 |
| Dendritic Ltd | Education | 2018 |
| Denmans Vale Management Limited | Households | 2020 |
| Derand Properties Ltd | Real estate | 2024 |
| Derby Tavern Ltd | Hospitality | 2026 |
| Derek Paravicini Entertainment Limited | Arts & recreation | 2011 |
| Dermahealth Limited | Health & social care | 2018 |
| Dermimax Limited | Wholesale & retail | 2023 |
| Descend Ltd | Construction | 2022 |
| Desi Spice Express Ltd | Hospitality | 2025 |
| Design Incorporated (UK) Limited | Administrative & support | 2002 |
| Design Signs (Salisbury) Limited | Manufacturing | 2015 |
| Design-Vertex Ltd | Professional & scientific | 2022 |
| Desire Petroleum Limited | Mining & quarrying | 1996 |
| Destination 11 Management Company Limited | Households | 2007 |
| Desy Thai Ltd | Hospitality | 2012 |
| Devizes Inn Limited | Extraterritorial | 2015 |
| Devon and Cornwall Windows Ltd | Construction | 2014 |
| Devonport Property Management Company Limited | Households | 2008 |
| Devony Holdings Limited | Financial services | 2025 |
| Dezi Welly Ltd | Professional & scientific | 2017 |
| DFH 7 Limited | Financial services | 2018 |
| DG DG Limited | Financial services | 2018 |
| Dhai Excellence Ltd | Health & social care | 2026 |
| DHC Solutions Ltd | Information & communication | 2010 |
| DI MEO Limited | Administrative & support | 2015 |
| Dial House Court Management Company Limited | Households | 2012 |
| Diamond Projects UK Limited | Professional & scientific | 2014 |
| Diani Consulting Ltd | Information & communication | 2019 |
| Didov Limited | Professional & scientific | 2025 |
| Diem UK Motorsport Ltd | Manufacturing | 2018 |
| Digital 23 Limited | Manufacturing | 2019 |
| Digital Dragonfly Ltd | Professional & scientific | 2022 |
| Digital Experts Personnel Limited | Administrative & support | 2012 |
| Digital Order Limited | Other services | 2011 |
| Digital Pathology Partners LLP | | 2018 |
| Digitalpad Consulting Ltd | Information & communication | 2025 |
| Digitpond Ltd | Information & communication | 2024 |
| Dignify Care Limited | Health & social care | 2016 |
| DIH Partnership Management Limited | Other services | 2013 |
| Dilly Meadows Management Company Limited | Households | 2017 |
| Dimatt Homes Ltd | Real estate | 2018 |
| Dinghams Direct Ltd | Wholesale & retail | 2021 |
| Dinghams Fireplaces Limited | Professional & scientific | 2003 |
| Dinghams Limited | Wholesale & retail | 2016 |
| Dinosaurs in the Park Limited | Hospitality | 2021 |
| Dinton Limited | Administrative & support | 2023 |
| Dinton Properties Limited | Construction | 2002 |
| Diocese of Salisbury Academy Trust | Education | 2013 |
| Dionysus Entertainment Limited | Hospitality | 2025 |
| Direct Care Childrens Homes Ltd | Health & social care | 2020 |
| Directions (Research and Marketing) Limited | Professional & scientific | 1987 |
| Dirty Little Publishers Limited | Information & communication | 2023 |
| Discover Adventure Limited | Administrative & support | 1994 |
| Disi NR1 Valeting Ltd | Other services | 2014 |
| Divine Brewing Company Ltd | Manufacturing | 2019 |
| Dixon-Clarke Consulting Limited | Professional & scientific | 2025 |