| Spicy Hot Monkey Ltd | Manufacturing | 2024 |
| Sport and Music Limited | Arts & recreation | 2008 |
| Sportivation Limited | Arts & recreation | 2015 |
| Sports Financial Services Holdings Limited | Financial services | 2016 |
| Sports Financial Services Limited | Administrative & support | 2008 |
| Sportsynth AI Ltd | Information & communication | 2026 |
| Spot & BOO Limited | Other services | 2025 |
| Spotlight Drama Ltd | Education | 2016 |
| Spotlight Drama Studio Ltd | Education | 2016 |
| Spotted by Football Club CIC | Education | 2024 |
| Spring&Summer Limited | Health & social care | 2024 |
| Sprinter Printer Group Ltd | Manufacturing | 2016 |
| SPS Electrical Contracting Limited | Construction | 2012 |
| Square One Lifestyle Homes Limited | Construction | 2004 |
| Squisharoo Ltd | Manufacturing | 2026 |
| SR ENT Services Limited | Professional & scientific | 2023 |
| SR Info Systems Ltd | Information & communication | 2011 |
| SR Sree Private Limited | Real estate | 2021 |
| SRC Manchester Ltd | Hospitality | 2025 |
| SRC Trading Group Ltd | Wholesale & retail | 2025 |
| Sree SAI Estates Ltd | Real estate | 2024 |
| Sreevatsa UK Limited | Wholesale & retail | 2020 |
| SRI Construction Private Ltd | Construction | 2026 |
| SRI Lankan Association of Northwest Community Interest Company | Arts & recreation | 2025 |
| SRI Ltd | Real estate | 2023 |
| Sridatta Properties Limited | Real estate | 2023 |
| Srikrishna Limited | Real estate | 2024 |
| SRN Care Ltd | Health & social care | 2020 |
| SRS Restaurants Ltd | Hospitality | 2018 |
| SSL Entertainment Limited | Arts & recreation | 2018 |
| Ssmv Home Investments Ltd | Real estate | 2026 |
| Ssniv Property Limited | Real estate | 2021 |
| Ssrj Limited | Professional & scientific | 2019 |
| ST Andrews House Management Company (Worsley) Limited | Households | 2004 |
| ST Andrews Place Stratton Management Company Limited | Households | 2019 |
| ST Johns (Ilkley) Management Company Limited | Households | 2007 |
| ST Margarets Management (Carbis Bay) Limited | Households | 2018 |
| ST Pauls Court (Hyde) Management Limited | Households | 1995 |
| ST Pauls Rise Flat Management Company Limited | Households | 2000 |
| Stadium Trade Frames Limited | Manufacturing | 2010 |
| Stage & Studio Projects Ltd | Construction | 2017 |
| Stage D Limited | Financial services | 2007 |
| STAIRCASE13 Limited | Information & communication | 2009 |
| Stalder Academy Limited | Education | 2017 |
| Stalder Productions Limited | Arts & recreation | 2007 |
| Stanley Court Management (NW) Ltd | Real estate | 2019 |
| Star Stream Properties Ltd | Real estate | 2024 |
| Stars & Moon Limited | Arts & recreation | 2025 |
| Statham Wealth Management Limited | Financial services | 2013 |
| Status Travel Ltd | Administrative & support | 2016 |
| Steama Company Limited | Information & communication | 2012 |
| Steele & Co (Hair) Limited | Other services | 2003 |
| Stellar Agile Consultancy Limited | Information & communication | 2016 |
| Stem E B Trading Ltd | Wholesale & retail | 2021 |
| Stem-Positive Ltd | Education | 2023 |
| Stephen Waldek Limited | Health & social care | 2018 |
| Stepwell Barns Limited | Hospitality | 2015 |
| Sterling Finance LLP | | 2001 |
| Sterling Tele Healthcare Limited | Health & social care | 2025 |
| Steve Allen Services Limited | Transport & logistics | 2015 |
| Steve Leathwhite Ltd | Transport & logistics | 2016 |
| Steve Marr Limited | Arts & recreation | 2008 |
| Steve Murphy Consultancy Limited | Administrative & support | 2023 |
| Stickman Holdings Limited | Real estate | 2024 |
| Stitch Happens Ltd | Wholesale & retail | 2025 |
| Stitch in Time MCR Ltd | Wholesale & retail | 2025 |
| STL Projects Limited | Professional & scientific | 2010 |
| Stockport Table Dictionary Limited | Other services | 2019 |
| Stone Giraffe Ltd | Manufacturing | 2026 |
| Stone Maker Properties Limited | Real estate | 2015 |
| Stonehenge General Trading Limited | Wholesale & retail | 2026 |
| Stonesfield Ltd | Real estate | 2025 |
| Stories Cheshire Ltd | Wholesale & retail | 2011 |
| Storks Heritage Limited | Information & communication | 2025 |
| Story Publishing Ltd | Information & communication | 2018 |
| Strados Property Group Ltd | Real estate | 2025 |
| Straight Road Consultancy Ltd | Professional & scientific | 2022 |
| Straight Road Housing Ltd | Real estate | 2023 |
| Stratagem Partners Ltd | Extraterritorial | 2025 |
| Streamcam Limited | Professional & scientific | 2023 |
| Streamline Car Finance Limited | Financial services | 2022 |
| Streamline Finance Ltd | Professional & scientific | 2022 |
| Stretford Road Management Company Limited | Households | 2006 |
| Stretton Ridge Advisory Ltd | Professional & scientific | 2025 |
| String of Hearts CIC | Health & social care | 2019 |
| Strong in the Park Ltd | Arts & recreation | 2022 |
| Stronger Steps Ltd | Health & social care | 2024 |
| STS Uk.Com Limited | Construction | 2009 |
| Stsuk Training Ltd | Professional & scientific | 2017 |
| Student Supplies Limited | Wholesale & retail | 2010 |
| Studio Chloe David Photography Ltd | Professional & scientific | 2024 |
| Studio Field Ltd | Professional & scientific | 2019 |
| Studio Freewheel Ltd | Information & communication | 2017 |
| Studio Grain Limited | Professional & scientific | 2026 |
| Studiosw Ltd | Administrative & support | 2016 |
| Style Supermall Ltd | Wholesale & retail | 2026 |
| Styvish Ltd | Wholesale & retail | 2022 |
| SU & Co Property Ltd | Real estate | 2021 |
| SUAN7 Ltd | Hospitality | 2018 |
| SUB FNH Limited | Hospitality | 2019 |