| SJ Property Alliance Ltd | Real estate | 2017 |
| SJC Investment Group Ltd | Administrative & support | 2017 |
| SJC Media and Training Limited | Professional & scientific | 2013 |
| SJC Risk Management Solutions Limited | Professional & scientific | 2010 |
| SK Eight Dental Limited | Health & social care | 2024 |
| SK Financial Consultants Ltd | Other services | 2010 |
| SK Smiley Teeth Limited | Health & social care | 2025 |
| Skanda Anaesthetic Services Ltd | Health & social care | 2019 |
| Skin Naturale Ltd | Manufacturing | 2012 |
| SKP Solutions Ltd | Financial services | 2025 |
| Sky Construction & Trading Ltd | Construction | 2022 |
| Sky International Properties Limited | Real estate | 2018 |
| Skye Horizon Property Ltd | Real estate | 2026 |
| Skyrise Property Developers Ltd | Construction | 2021 |
| Skyvan Property Ltd | Households | 2023 |
| SL Holdings (MCR) Ltd | Real estate | 2017 |
| Slacky's Classic Campervan and Car Hire Limited | Real estate | 2014 |
| Slade Flooring Limited | Wholesale & retail | 2013 |
| Slarka Ltd | Professional & scientific | 2022 |
| Slasherclass Limited | Information & communication | 2021 |
| Slater Heelis (Horizon) LLP | | 2012 |
| Slater Heelis Limited | Professional & scientific | 2020 |
| Slater Heelis Services Limited | Administrative & support | 2013 |
| Slater Heelis SIP Trustees Company Limited | Professional & scientific | 2022 |
| Slater Heelis Trust Corporation Limited | Professional & scientific | 2019 |
| Slatterys Bars and Pubs Limited | Hospitality | 2022 |
| Slcg Property Services Limited | Professional & scientific | 2016 |
| Sleep and Therapy Services CIC | Health & social care | 2021 |
| SLM Expert Witness Ltd | Other services | 2024 |
| SM Events Limited | Administrative & support | 2022 |
| SM Substation Services Ltd | Professional & scientific | 2015 |
| SM92 Agency Ltd | Information & communication | 2016 |
| Smaak Ltd | Hospitality | 2025 |
| Small Sparks Ltd | Information & communication | 2024 |
| Smart Brain Factory Ltd | Manufacturing | 2020 |
| Smart Electronics Ltd | Wholesale & retail | 2013 |
| Smart Honey Bees Ltd | Real estate | 2022 |
| Smart Mortgage Group and Protection Ltd | Financial services | 2026 |
| Smartmoneycreative Limited | Professional & scientific | 2023 |
| Smartsip Ltd | Wholesale & retail | 2025 |
| Smarttouch Limited | Education | 2002 |
| Smarty Solution Limited | Information & communication | 2013 |
| Smba Global Ltd | Wholesale & retail | 2016 |
| Smba Limited | Professional & scientific | 2016 |
| Sme's Solutions Private Ltd | Administrative & support | 2016 |
| Smile Manchester Ltd | Health & social care | 2016 |
| Smith Healthcare Ltd | Health & social care | 2025 |
| Smoof App Ltd | Information & communication | 2025 |
| Smpcosmetics Ltd | Health & social care | 2024 |
| Smvc Traders Limited | Wholesale & retail | 2025 |
| SN Retail Ltd | Wholesale & retail | 2020 |
| Snaefell Consultants LP | | 2009 |
| Snaefell Estates LP | | 2008 |
| Snapaway Limited | Information & communication | 2025 |
| Sneve Holdings Ltd | Information & communication | 2020 |
| Snmf Health Limited | Health & social care | 2024 |
| SO Synergy Ltd | Construction | 2024 |
| Soaldach Ltd | Wholesale & retail | 2024 |
| Soar Ventures Ltd | Wholesale & retail | 2021 |
| Social Journey Ltd | Administrative & support | 2018 |
| Social Spoon Ltd | Professional & scientific | 2023 |
| Societe Noir Fashion Ltd | Wholesale & retail | 2015 |
| Solace Pilates Studios Limited | Education | 2025 |
| Solartrack Systems Limited | Information & communication | 2001 |
| Soledair Barber Limited | Other services | 2022 |
| Solid Brick Properties Limited | Real estate | 2022 |
| Solutionising Ltd | Information & communication | 2018 |
| Somer Property Investment Ltd | Real estate | 2018 |
| Somitex Morocco (S.A.) | | 2012 |
| Somjai Infotech Ltd | Real estate | 2025 |
| Sommerville Court Limited | Households | 1971 |
| Sona Medical Solutions Ltd | Information & communication | 2026 |
| Song Nails Limited | Other services | 2018 |
| Sonvanes Ltd | Information & communication | 2019 |
| Sophia Fleming Consulting Limited | Professional & scientific | 2019 |
| Sophie Marie Aesthetics Ltd | Other services | 2024 |
| Sophie Marie Studios Ltd | Other services | 2021 |
| Soroki Ltd | Administrative & support | 2014 |
| Sortal Ltd | Information & communication | 2022 |
| Soupajuice Limited | Wholesale & retail | 2009 |
| South Manchester Cricket Academy Ltd | Education | 2026 |
| South MCR Lettings Ltd | Real estate | 2020 |
| South Point Motors Limited | Wholesale & retail | 2002 |
| South West Intervention Services Holdings Limited | Financial services | 2019 |
| South West Intervention Services Limited | Education | 2016 |
| Sovereign House Management (Sheff) Ltd | Real estate | 2019 |
| Space Blue Limited | Manufacturing | 2019 |
| Space Cakes Ltd | Manufacturing | 2025 |
| Spafield Limited | Manufacturing | 2020 |
| Spark HR Limited | Administrative & support | 2013 |
| Sparkle Detailing Centre Limited | Wholesale & retail | 2025 |
| Sparkle Properties Ltd | Real estate | 2018 |
| Sparrowhawk Investment Limited | Real estate | 2025 |
| SPC Partnership Limited | Construction | 2009 |
| Spectre Financial Group Trading Ltd | Financial services | 2017 |
| Speedrite (N.E.) Limited | Manufacturing | 2003 |
| Speedy Charge Limited | Construction | 2023 |
| Spel Engineering Services Ltd | Construction | 2023 |
| Spend Well Stores Limited | Wholesale & retail | 2019 |
| Spice Suppliers Limited | Hospitality | 2022 |