| Sale Grammar School | Education | 2011 |
| Sale Healthcare Limited | Wholesale & retail | 2023 |
| Sale Insurance Services Ltd | Financial services | 2003 |
| Sale Leisure Ltd | Hospitality | 2022 |
| Sale Local Ltd | Wholesale & retail | 2025 |
| Sale Mediterranean Ltd | Hospitality | 2026 |
| Sale Moon Ltd | Wholesale & retail | 2023 |
| Sale Moor Community Partnership Ltd. | Health & social care | 2005 |
| Sale Moor Scaffolding Ltd | Construction | 2015 |
| Sale Motors Ltd | Wholesale & retail | 2023 |
| Sale One Stop Limited | Wholesale & retail | 2025 |
| Sale Podiatry Limited | Health & social care | 2023 |
| Sale Project Services Ltd | Professional & scientific | 2012 |
| Sale Spice (NW) Ltd | Hospitality | 2026 |
| Sale Sports Trading Limited | Arts & recreation | 2018 |
| Sale Transport Limited | Transport & logistics | 2014 |
| Sale V.A.G Centre Ltd | Wholesale & retail | 2019 |
| Sale Van Sales Ltd | Wholesale & retail | 2026 |
| Sale Weight Training Club Ltd | Arts & recreation | 1998 |
| Sale Youth Choirs CIC | Education | 2022 |
| Salei Homes Ltd | Real estate | 2026 |
| Sales & Marketing Services UK Limited | Wholesale & retail | 2023 |
| Sales for Startups Limited | Professional & scientific | 2017 |
| Sally Social Digital Ltd | Professional & scientific | 2021 |
| Samniteco Ltd | Health & social care | 2014 |
| Sampharma MCR Limited | Health & social care | 2024 |
| SAN SAN 2025 Limited | Hospitality | 2025 |
| Sand and Brick Ltd | Real estate | 2020 |
| Sandcliffe Investments (Milton Keynes) LLP | | 2006 |
| Sandcliffe Investments Property (Adex Interiors) LLP | | 2008 |
| Sandcliffe Investments Property (Advanced) LLP | | 2007 |
| Sandy Lane Service Station Limited | Administrative & support | 2003 |
| Sangam Bowdon Ltd | Hospitality | 2019 |
| Sanneh Railway Line Ltd | Other services | 2016 |
| Sanrill Ltd | Real estate | 2021 |
| Santara Thai Wellness Ltd | Health & social care | 2025 |
| Santosendoscopist Limited | Health & social care | 2023 |
| Santosh IT Solutions Ltd | Information & communication | 2026 |
| Sanya Foods Limited | Wholesale & retail | 2024 |
| Sanyu IT & Management Services Ltd | Wholesale & retail | 2013 |
| Sapkal Studios Limited | Wholesale & retail | 2025 |
| Sapsama Group Limited | Professional & scientific | 2017 |
| Sapsama Ltd | Professional & scientific | 2023 |
| Sarah Mckie Ltd | Health & social care | 2024 |
| Sarala Systems Limited | Information & communication | 2025 |
| Saroj Foods Limited | Hospitality | 2026 |
| Sarpanch News Ltd | Wholesale & retail | 2025 |
| Sarr Technologies Limited | Information & communication | 2012 |
| Sartori Ltd | Wholesale & retail | 2023 |
| SAS Innovations Solutions Ltd | Wholesale & retail | 2025 |
| SAS Maintenance Services Ltd | Construction | 2016 |
| Sas-Reeview Limited | Administrative & support | 2020 |
| Satins Services Limited | Health & social care | 2024 |
| Satsuma Marketing Limited | Professional & scientific | 2016 |
| Savimedics Limited | Health & social care | 2020 |
| Sawhe CIC | Education | 2026 |
| Saxon Coatings Ltd | Manufacturing | 2019 |
| Saxon Global Group Ltd | Financial services | 2022 |
| Saxon Paints Ltd | Manufacturing | 2022 |
| SB Costs Ltd | Professional & scientific | 2014 |
| SB FD Services Limited | Administrative & support | 2016 |
| SB Manchester Co Limited | Hospitality | 2025 |
| Sbbs Holdings Limited | Financial services | 2008 |
| SBE Consultancy Limited | Education | 2019 |
| SBI Manchester Properties Ltd | Construction | 2023 |
| SC Building Consultancy Limited | Professional & scientific | 2012 |
| SC Glazing Limited | Construction | 2012 |
| Scale Agent Technologies Ltd | Information & communication | 2025 |
| SCD Creative Ltd | Professional & scientific | 2025 |
| School of Movement Free Spirit CIC | Education | 2025 |
| Schooldatalab Ltd | Information & communication | 2025 |
| Schools Safeguarding North Ltd | Education | 2021 |
| Science EVE Ltd | Information & communication | 2024 |
| Scigrid Ltd | Information & communication | 2024 |
| Score Perks Ltd | Administrative & support | 2025 |
| Scorpio Conseil Ltd | Wholesale & retail | 2023 |
| Scott Donald Architecture Ltd | Professional & scientific | 2011 |
| Scotti Knights Motorcycle Training Limited | Arts & recreation | 2007 |
| Scotts Private Hire Taxis Ltd | Transport & logistics | 2013 |
| Scoutd.Ai Limited | Information & communication | 2025 |
| Scrumbuild Limited | Construction | 2017 |
| Scudder Consultancy Ltd | Information & communication | 2026 |
| Sculpt Pro Solutions Limited | Wholesale & retail | 2019 |
| Scythe Consulting Ltd | Professional & scientific | 2020 |
| SD Cosmetics Ltd | Other services | 2018 |
| Sd&M Consulting Limited | Professional & scientific | 2019 |
| Sdcpublishing Ltd | Information & communication | 2017 |
| Sdcs Limited | Professional & scientific | 2001 |
| SDW Properties Limited | Real estate | 2019 |
| Seashells Day Nursery Ltd | Administrative & support | 2017 |
| Seaside Care Homes Limited | Health & social care | 2008 |
| Seavoie Limited | Wholesale & retail | 2019 |
| Second Chance-Uk Ltd | Education | 2023 |
| Secret Days Limited | Information & communication | 2015 |
| Secure IT Consult Limited | Information & communication | 2015 |
| Secured Access Maintenance Ltd | Administrative & support | 2019 |
| Securo Guard Group Limited | Administrative & support | 2020 |
| Securo Guard Limited | Other services | 2020 |
| Securo Property Group Limited | Real estate | 2023 |
| Securo Training Limited | Education | 2022 |