| Salon 21 Ltd | Other services | 2021 |
| Salon 29 Hair & Beauty Ltd | Other services | 2023 |
| Salon Unique Limited | Other services | 2013 |
| Samuel Bevan Associates Limited | Administrative & support | 2012 |
| Sansom Civil Engineering Ltd | Construction | 2024 |
| Satiny Ltd | Hospitality | 2016 |
| Satsy Ltd | Information & communication | 2020 |
| Sauce Events Limited | Hospitality | 2024 |
| Savilerowsporting Limited | Manufacturing | 2016 |
| SAW CAP Limited | Real estate | 2019 |
| SAW Pensions Ltd | Professional & scientific | 2014 |
| SB UK Holdco Limited | Real estate | 2025 |
| SC Llewellyn Consulting Limited | Professional & scientific | 2017 |
| SCD Consultancy Ltd | Professional & scientific | 2019 |
| SCI Asbestos Sampling Limited | Extraterritorial | 2012 |
| SCI Central Limited | Financial services | 2005 |
| SCI Environmental Group Limited | Professional & scientific | 2010 |
| SCI South Ltd | Financial services | 2023 |
| SCI Waste Streams Ltd | Financial services | 2018 |
| Scope Roofing Limited | Construction | 2010 |
| Scorpion Interiors Ltd | Wholesale & retail | 2025 |
| Scott Associates Limited | Administrative & support | 2007 |
| Screwbean Ltd | Hospitality | 2016 |
| Scrit Ltd | Professional & scientific | 2025 |
| Sculpture-Safe Ltd | Real estate | 2020 |
| SDB Holdings Limited | Administrative & support | 2016 |
| SEB Rugeley Ltd | Wholesale & retail | 2026 |
| Sebastian Tombs Enterprises Ltd | Information & communication | 2014 |
| SEE Sustain Science (Consulting) Ltd | Professional & scientific | 2021 |
| Selliah SRI Ltd | Wholesale & retail | 2025 |
| Sensor Magic Ltd | Manufacturing | 2022 |
| Sentinel Stone Ltd | Real estate | 2025 |
| Seoulsic Ltd | Wholesale & retail | 2026 |
| Severance Tattoo Ltd | Arts & recreation | 2018 |
| Severn Valley Direct Cremation Ltd | Other services | 2025 |
| SFM Staffing Solutions Ltd | Administrative & support | 2020 |
| Sgge Ltd | Hospitality | 2024 |
| Sggs Property Group Ltd | Real estate | 2026 |
| Sgnd Properties Ltd | Real estate | 2026 |
| Shaw Holdings Assets & Wealth Ltd | Real estate | 2024 |
| Shawsters Ltd | Administrative & support | 2024 |
| Shbk Bookkeeping and Consulting Limited | Information & communication | 2014 |
| Sheila Harper Limited | Education | 2007 |
| Sherpur Express Ltd | Hospitality | 2024 |
| Shire Travel International Limited | Transport & logistics | 2001 |
| Shiventures Limited | Hospitality | 2008 |
| Shots & Co UK Ltd | Financial services | 2026 |
| Shrew Pubs Ltd | Hospitality | 2026 |
| Siai Ltd | Wholesale & retail | 2025 |
| Sians Special Occassions Ltd | Hospitality | 2016 |
| Simon Bashford Entertainments Limited | Arts & recreation | 2004 |
| Simtech Electrical Solutions Limited | Construction | 2025 |
| Sirianni Property Ltd | Real estate | 2022 |
| Siscrow Telecomms Limited | Information & communication | 2012 |
| Sixmil Airsoft Limited | Arts & recreation | 2023 |
| SIXTY5 Limited | Administrative & support | 2017 |
| Sjaaa Ltd | Hospitality | 2019 |
| SJS (Number 1) Limited | Other services | 2023 |
| Skilledbiker Ltd | Education | 2021 |
| SKS Project Services Ltd | Construction | 2025 |
| Skye Masonry 2012 Ltd | Manufacturing | 2012 |
| Skyline Cleaning Experts Ltd | Administrative & support | 2025 |
| Skyline Padel Limited | Arts & recreation | 2024 |
| SLB Supply Chain Limited | Professional & scientific | 2024 |
| Slinky Interiors Limited | Administrative & support | 2006 |
| Slitting Mill Services Ltd | Professional & scientific | 2026 |
| SM Rugeley Ltd | Wholesale & retail | 2024 |
| Small Business Equaliser Ltd | Professional & scientific | 2022 |
| Small Business Vibes Ltd | Administrative & support | 2024 |
| SMR Comms Limited | Information & communication | 2024 |
| SMS Plant Hire Limited | Administrative & support | 1998 |
| SMW Nexus Group Limited | Financial services | 2025 |
| Sngd Ltd | Wholesale & retail | 2025 |
| SNS Vehicle Body Repair Ltd | Wholesale & retail | 2024 |
| Snugfit Windows (Rugeley) Limited | Construction | 2008 |
| SO Plant Hire Ltd | Construction | 2025 |
| Social & Community Energy Limited | Energy | 2019 |
| Social Income Limited | Real estate | 2019 |
| Soila Turkish Barber Ltd | Other services | 2025 |
| Solarae Limited | Wholesale & retail | 2011 |
| Solutions SAM Tech Limited | Information & communication | 2022 |
| Sorella Events Limited | Other services | 2011 |
| Southall Solutions Ltd | Construction | 2016 |
| Spalding Biogas Limited | Energy | 2016 |
| Sparkely Ltd | Wholesale & retail | 2025 |
| Speakeeasy Ltd | Manufacturing | 2026 |
| Specialist Aggregates Limited | Manufacturing | 1999 |
| Speed-Ex Logistics Limited | Transport & logistics | 2016 |
| Sphere Utility Services Limited | Construction | 2017 |
| Spires Digital Ltd | Professional & scientific | 2022 |
| Sporting PB Ltd | Education | 2023 |
| Sports Affiliates Limited | Education | 2021 |
| Spraybooth Service and Maintenance Limited | Manufacturing | 2013 |
| Spraybooth Supermarket Limited | Manufacturing | 2021 |
| Spring Hill Residents Association Limited | Real estate | 1972 |
| Springhill Court Limited | Households | 1991 |
| SPS Roofing (Rugeley) Limited | Construction | 2014 |
| SRM Embroidery & Business Services Ltd | Wholesale & retail | 2025 |
| ST Aldates Investments Limited | Financial services | 1995 |
| ST Aldates Properties Limited | Hospitality | 1998 |