| Scandinavian Bioenergy Services Ltd | Professional & scientific | 2024 |
| Scarlett Oak Ltd | Real estate | 2021 |
| SCH Tech Ltd | Information & communication | 2014 |
| Scholaby Limited | Real estate | 2023 |
| School Health UK Limited | Education | 2016 |
| School of RAP CIC | Health & social care | 2024 |
| Scissor Sisters (Atherstone) Ltd. | Other services | 2009 |
| Scoeducation Ltd | Education | 2024 |
| Scoobyrooms Limited | Wholesale & retail | 2015 |
| Scorpion Sports Cars Ltd | Manufacturing | 2010 |
| Scotia Enterprises Ltd | Transport & logistics | 2007 |
| SCR Doors Ltd | Construction | 2022 |
| Screen-Kleen Limited | Manufacturing | 2010 |
| Screening Consultancy and Supplies Ltd. | Other services | 1991 |
| Screwcaps Limited | Administrative & support | 2013 |
| SCS Holdings Limited | Financial services | 2009 |
| SCT Logistics Services Ltd | Transport & logistics | 2024 |
| Sculpture Machine Ltd | Arts & recreation | 2003 |
| Scythe Limited | Professional & scientific | 2019 |
| SDC Trucking Ltd | Transport & logistics | 2024 |
| Sde-Psr Ltd | Professional & scientific | 2010 |
| SDH Academy Ltd | Arts & recreation | 2021 |
| SDK Digitech Limited | Wholesale & retail | 2018 |
| SDS Care Limited | Health & social care | 2014 |
| Sdss Consultancy Limited | Information & communication | 2016 |
| Sdtpms Limited | Information & communication | 2013 |
| SDW Carpentry & Joinery Ltd | Construction | 2016 |
| Seagle Logistics Ltd | Transport & logistics | 2026 |
| Seahorse Elmesthorpe Limited | Manufacturing | 2026 |
| Seama Capital Limited | Transport & logistics | 2017 |
| Sear & Cowen Glass & Glazing Services Limited | Construction | 2007 |
| Search Mortgages Limited | Financial services | 2010 |
| Searlait Ltd. | Information & communication | 2009 |
| Season 4 (CTA) Limited | Hospitality | 2020 |
| Sebing 2014 Ltd | Construction | 2018 |
| Sechville Property Group Limited | Real estate | 2024 |
| Secumedi Solutions Ltd | Wholesale & retail | 2024 |
| Secure State International Limited | Administrative & support | 2024 |
| Secusolutions Limited | Manufacturing | 2015 |
| Sedlescombe Lodge Company Limited | Real estate | 2000 |
| Seera Property & Development Ltd | Households | 2022 |
| SEEVEE21 Properties Ltd | Real estate | 2024 |
| Sekhon Carriers Ltd | Transport & logistics | 2021 |
| Sell & Produce Original Talent Ltd. | Professional & scientific | 2023 |
| Sempiternal Efficient Software Solutions Limited | Information & communication | 2017 |
| Sempre Violin Ltd | Education | 2020 |
| SEN Consultancy Services Ltd | Professional & scientific | 2017 |
| SEN Rugby Limited | Hospitality | 2014 |
| Senlin Cuisine Limited | Hospitality | 2024 |
| Sensational Tutors Limited | Education | 2017 |
| Sentis Limited | Information & communication | 1997 |
| Sentra AI Ltd | Information & communication | 2025 |
| Senza Holdings Ltd | Health & social care | 2018 |
| Serdel Ltd | Transport & logistics | 2023 |
| Serene Care Ltd | Health & social care | 2014 |
| Serenitas Consulting Limited | Professional & scientific | 2021 |
| Sergio's Transport Ltd | Transport & logistics | 2023 |
| Service on Demand Ltd | Other services | 2021 |
| Service Solutions Rugby Limited | Professional & scientific | 2005 |
| Setpower Estates Limited | Construction | 2025 |
| Setpower Limited | Construction | 2002 |
| Seunyinka Ltd | Real estate | 2019 |
| Seven Nuneaton Limited | Hospitality | 2021 |
| SEVEN82 Services Limited | Professional & scientific | 2021 |
| Seville FM Limited | Financial services | 2018 |
| Seville Oxford Ltd | Administrative & support | 2005 |
| Seymour Court (Woolacombe) Management Company Limited | Hospitality | 1999 |
| Seysan Ltd | Real estate | 2022 |
| SF Subway Ltd | Hospitality | 2023 |
| SFR (GB) Limited | Professional & scientific | 2001 |
| SFX (GB) Limited | Arts & recreation | 2011 |
| SG Power Ltd | Administrative & support | 2024 |
| Sg-Mw Ltd | Transport & logistics | 2011 |
| Sgeorge Ltd | Transport & logistics | 2019 |
| Shabs Construction Ltd | Construction | 2020 |
| Shades of Soul Limited | Arts & recreation | 2009 |
| Shakes Global Ltd | Hospitality | 2020 |
| Shakti Asset Management Limited | Financial services | 2016 |
| Sham Property Solutions Ltd | Real estate | 2025 |
| Shambhu Logistics Limited | Transport & logistics | 2017 |
| Shankster and Daughters Property Limited | Real estate | 2026 |
| Shankster and Daughters Trading Limited | Professional & scientific | 2016 |
| Shans Estate Developments Limited | Real estate | 2024 |
| Shape Health Consulting Ltd | Health & social care | 2021 |
| Shape IT UP Pilates Limited | Arts & recreation | 2017 |
| Shapecraft Holding Limited | Financial services | 2017 |
| Shapejoint Limited | Financial services | 2002 |
| Sharktronics Ltd | Wholesale & retail | 2026 |
| Sharma & PA Limited | Real estate | 2025 |
| Sharma Food Services Limited | Wholesale & retail | 2026 |
| Sharma Hospitality Ltd | Financial services | 2025 |
| Shaun,S Haulage Ltd | Transport & logistics | 2018 |
| Shauns Express Limited | Transport & logistics | 2022 |
| Shaw-Haul (Midlands) Limited | Transport & logistics | 2017 |
| Shaw-Haul-Clears ALL Ltd | Extraterritorial | 2024 |
| Shay Brennan Golf Limited | Arts & recreation | 2015 |
| Shayne Dawkins Ltd | Transport & logistics | 2025 |
| Shearwood Europe Limited | Transport & logistics | 2011 |
| Shecares Ltd | Professional & scientific | 2025 |
| Shelden Healthcare UK Limited | Health & social care | 2015 |