| Saffron Frameworks Limited | Other services | 2013 |
| Safwan Properties Limited | Real estate | 2017 |
| Saga 1 Ltd | Health & social care | 2022 |
| Sagoo Property Management Ltd | Real estate | 2023 |
| Sah&Rin Transport Ltd | Transport & logistics | 2019 |
| Sahi Builders Ltd | Construction | 2022 |
| Sahota Design Ltd | Information & communication | 2023 |
| SAI Advitha Limited | Health & social care | 2024 |
| SAI Cloudops Ltd | Information & communication | 2019 |
| SAI WMS Consulting Limited | Wholesale & retail | 2022 |
| Saiansh Ltd | Real estate | 2016 |
| Saif&Aliya Limited | Administrative & support | 2012 |
| Sailstransport Ltd | Transport & logistics | 2018 |
| Saivi Ltd | Information & communication | 2025 |
| Sajmon RS Transport Ltd | Transport & logistics | 2019 |
| SAK Motorcycles Limited | Wholesale & retail | 2023 |
| Sako SG Ltd | Transport & logistics | 2020 |
| Saktech Engineering Services Ltd. | Professional & scientific | 2022 |
| Sakura Kitchen Limited | Hospitality | 2019 |
| Sales Projects Limited | Information & communication | 2010 |
| Sales Spectrum Ltd | Wholesale & retail | 2026 |
| Salestart Limited | Real estate | 2005 |
| Salisbury Street Investments Limited | Financial services | 2016 |
| Salon 45 Limited | Other services | 2005 |
| Salon 79 Limited | Other services | 2015 |
| Salters of Rugby Limited | Wholesale & retail | 2016 |
| Salus Solutio Limited | Professional & scientific | 2010 |
| Salute Photography & Studio Ltd | Professional & scientific | 2021 |
| Salven Properties Limited | Extraterritorial | 2006 |
| SAM Clinical Research Limited | Professional & scientific | 2026 |
| SAM Grafton Enterprises Ltd | Administrative & support | 2021 |
| Sam's Transport (Heathrow) Limited | Transport & logistics | 1983 |
| Sam's Transport (Holdings) Ltd | Financial services | 2015 |
| Samalin Ltd | Transport & logistics | 2017 |
| Samlet Road LLP | | 2019 |
| Samond Buildings Ltd | Construction | 2024 |
| Samond Group Ltd | Real estate | 2021 |
| Samruddi Limited | Real estate | 2023 |
| Samzone Ltd | Transport & logistics | 2013 |
| Sanctuaryeleven Ltd | Wholesale & retail | 2021 |
| Sandeep Solanki Ltd | Information & communication | 2021 |
| Sandercott Project Engineering Ltd | Professional & scientific | 2015 |
| Sandguard Ltd. | Administrative & support | 2011 |
| Sandi Gunn Ltd | Professional & scientific | 2026 |
| Sankalp Estates Ltd | Real estate | 2025 |
| Santa Moving Services Ltd | Transport & logistics | 2022 |
| Santa Moving Solutions Ltd | Transport & logistics | 2025 |
| Santa Real Estate Ltd | Real estate | 2024 |
| Santa Removals Ltd | Transport & logistics | 2017 |
| Santa Storage Ltd | Transport & logistics | 2023 |
| Sante Consultancy Ltd | Health & social care | 2023 |
| Santiago Consult Ltd | Professional & scientific | 2025 |
| Sapminds Solution Limited | Information & communication | 2025 |
| Sara Black Service Ltd | Wholesale & retail | 2018 |
| Sara Black Spedition Limited | Transport & logistics | 2026 |
| Saracen Commercial Contracting Limited | Transport & logistics | 2005 |
| Sarah Boddy Limited | Administrative & support | 2003 |
| Sarah Dougherty Limited | Other services | 2022 |
| Sarah Morrison Heritage Restoration Limited | Construction | 2023 |
| Sarah Transport Limited | Manufacturing | 2016 |
| Saray Rugby Ltd | Hospitality | 2024 |
| Sarc Developments Limited | Manufacturing | 1982 |
| Sard Foods Ltd | Hospitality | 2026 |
| SAS Consulting Ltd | Professional & scientific | 2013 |
| Sash Clintech Limited | Information & communication | 2025 |
| Sash Restore Ltd | Construction | 2013 |
| Sasmi and Pinky Limited | Wholesale & retail | 2026 |
| Sass Rugby Limited | Wholesale & retail | 2015 |
| Sastruga Solutions Ltd | Information & communication | 2016 |
| Satat Properties Ltd | Water & waste | 2020 |
| Satat Retail Earlsheaton Ltd | Wholesale & retail | 2025 |
| Satat Retail Ltd | Wholesale & retail | 2023 |
| Satat Retail Staincliffe Ltd | Wholesale & retail | 2026 |
| Satchmo Solutions Limited | Professional & scientific | 1999 |
| Satchmo's Corner Limited | Hospitality | 2022 |
| Satellite Graphic Production Limited | Administrative & support | 2009 |
| Sathan Ramachandran Limited | Professional & scientific | 2025 |
| Sathasree Limited | Real estate | 2025 |
| Sathish Properties Ltd | Real estate | 2021 |
| Satina Care Services Ltd | Health & social care | 2022 |
| Satori Estates Limited | Real estate | 2023 |
| Satsangi Consulting Limited | Professional & scientific | 2025 |
| Sattler Technology UK Ltd | Wholesale & retail | 2026 |
| Savanna Blue Limited | Wholesale & retail | 2005 |
| Save OUR UK Ltd | Agriculture & fishing | 2025 |
| Savoirvivrée Limited | Wholesale & retail | 2026 |
| Savtech Systems Ltd | Manufacturing | 2015 |
| Saxon Fields Farm Ltd | Extraterritorial | 2020 |
| SAY MGT Limited | Administrative & support | 2023 |
| Sayaki INV Ltd | Real estate | 2024 |
| SB Medicolegal Limited | Health & social care | 2010 |
| SB Pickleball Ltd | Arts & recreation | 2022 |
| Sb.Touch Ltd | Information & communication | 2015 |
| SBM Vision Limited | Wholesale & retail | 2025 |
| SBS Nordstrom Ltd | Financial services | 2025 |
| Sbsc Properties Ltd | Construction | 2025 |
| SC Automotive & Race Engineering Ltd | Wholesale & retail | 2011 |
| SC Healthcare Limited | Public administration | 2017 |
| SC Tiling Limited | Construction | 2023 |
| Scandieco Solutions Ltd | Wholesale & retail | 2023 |