| Solid BC Ltd | Manufacturing | 2025 |
| Solid Guidance Property Training Ltd | Education | 2025 |
| Solution Focused Education Ltd | Other services | 2022 |
| Solution Navigator Ltd | Professional & scientific | 2022 |
| Solution Worx Limited | Information & communication | 2006 |
| Solutions 23 Limited | Wholesale & retail | 2014 |
| Solutions Focused Coaching Ltd | Other services | 2022 |
| Solve Care Ltd | Health & social care | 2026 |
| Someday Media Ltd | Information & communication | 2008 |
| Something Digital Limited | Information & communication | 2003 |
| Sommerville House Ltd | Professional & scientific | 2023 |
| SON Duong Property Ltd | Real estate | 2025 |
| Sonars Limited | Wholesale & retail | 2005 |
| Sonic Accountancy Limited | Professional & scientific | 2025 |
| Sonic Letting Limited | Real estate | 2024 |
| Sons of Guns Group Limited | Wholesale & retail | 2022 |
| Sons of Guns Independent Spray Parlour Limited | Wholesale & retail | 2022 |
| Sons of Guns Paint Parlour Limited | Manufacturing | 2019 |
| Sons of Guns Threads Inc Limited | Wholesale & retail | 2022 |
| Sopson Limited | Wholesale & retail | 2024 |
| Sorbus Capital Ltd | Financial services | 2023 |
| Sorola Energy Limited | Other services | 2020 |
| Sorrento Review Ltd | Administrative & support | 2023 |
| Sorted 24/7 Transport Services Ltd | Transport & logistics | 2014 |
| Sorted April Limited | Other services | 2025 |
| SOS Security Rotherham Ltd | Administrative & support | 2012 |
| Soul Rotherham CIC | Arts & recreation | 2026 |
| Soul Spark Ltd | Wholesale & retail | 2024 |
| Sourdough Slingers Ltd | Hospitality | 2021 |
| South East Coalville Management Company Limited | Households | 2020 |
| South Grove Garage Limited | Wholesale & retail | 2007 |
| South Grove House Limited | Professional & scientific | 2008 |
| South Road 74 Limited | Extraterritorial | 2014 |
| South West Properties (South Yorkshire) Limited | Real estate | 2017 |
| South West Wind Holdco Ltd | Financial services | 2022 |
| South Yorks Roofcare Ltd | Construction | 2025 |
| South Yorkshire Aesthetics Limited | Other services | 2022 |
| South Yorkshire Air Conditioning & Refrigeration Limited | Manufacturing | 2008 |
| South Yorkshire Building Supplies Limited | Wholesale & retail | 2026 |
| South Yorkshire Car & Commercial Centre Ltd | Wholesale & retail | 2015 |
| South Yorkshire Car Centre Ltd | Real estate | 2007 |
| South Yorkshire CBT Ltd | Health & social care | 2019 |
| South Yorkshire Composites Ltd | Wholesale & retail | 2018 |
| South Yorkshire Developments Limited | Real estate | 2022 |
| South Yorkshire Drylining Ltd | Construction | 2020 |
| South Yorkshire Glass and Glazing Ltd | Construction | 2022 |
| South Yorkshire Haulage Ltd | Transport & logistics | 2022 |
| South Yorkshire Housing Limited | Real estate | 2024 |
| South Yorkshire Kart Club Limited | Arts & recreation | 1993 |
| South Yorkshire Laser Ltd | Professional & scientific | 2022 |
| South Yorkshire Lettings and Sales Limited | Real estate | 2025 |
| South Yorkshire Mobility Ltd | Wholesale & retail | 2018 |
| South Yorkshire Ostomy Supplies (Holdings) Ltd | Health & social care | 2018 |
| South Yorkshire Ostomy Supplies Ltd | Health & social care | 2013 |
| South Yorkshire Paediatric Orthopaedic Services Limited | Extraterritorial | 2022 |
| South Yorkshire Pest Control Limited | Agriculture & fishing | 2017 |
| South Yorkshire Plumbing & Building Services Limited | Construction | 2011 |
| South Yorkshire PLY Lining Ltd | Administrative & support | 2023 |
| South Yorkshire Preservation Group CIC | Transport & logistics | 2025 |
| South Yorkshire Properties Ltd | Real estate | 2017 |
| South Yorkshire Provider Network Limited | Education | 2017 |
| South Yorkshire Refrigerated Trailer Hire Ltd | Hospitality | 2022 |
| South Yorkshire Roofing and Cladding Services Ltd | Construction | 2026 |
| South Yorkshire School Business Leaders C.I.C. | Education | 2022 |
| South Yorkshire Spine Limited | Health & social care | 2017 |
| South Yorkshire Systems Ltd | Construction | 2021 |
| South Yorkshire Terrapin & Tortoise Rescue Limited | Wholesale & retail | 2025 |
| South Yorkshire Timber Framing Limited | Construction | 2023 |
| South Yorkshire Trade Windows and Doors Ltd | Manufacturing | 2020 |
| South Yorkshire Transport Museum Ltd | Arts & recreation | 1995 |
| South Yorkshire Tuning Ltd | Wholesale & retail | 2025 |
| South Yorkshire Vehicles Ltd | Administrative & support | 2026 |
| South Yorkshire WH Community CIC | Wholesale & retail | 2023 |
| South Yorkshire Windows Ltd | Construction | 2018 |
| Southern Counties Lift Services Limited | Administrative & support | 1984 |
| Sovereign Security Services Consultants Limited | Administrative & support | 2016 |
| SP Brand Consultancy Limited | Administrative & support | 2016 |
| SP Drylining Ltd | Construction | 2021 |
| SP Kitchens and Bedroom Installations Limited | Construction | 2017 |
| SP Letting Agents Limited | Real estate | 2019 |
| SP Manpower Ltd | Administrative & support | 2021 |
| SP Safety Solution UK Limited | Professional & scientific | 2026 |
| SP Security Ltd | Administrative & support | 2024 |
| Spa Ceylon International PVT Ltd | Wholesale & retail | 2023 |
| Spark (Holdings) Ltd. | Professional & scientific | 1998 |
| Sparks Will FLY - Emergency Electrical Services Limited | Construction | 2014 |
| Sparksmiths Limited | Construction | 2021 |
| SPARKYS4U Ltd | Construction | 2013 |
| Spartan Electrical Projects Ltd | Construction | 2023 |
| Spartan Roofing Services Limited | Construction | 2025 |
| Spartan Upholstery Limited | Wholesale & retail | 2019 |
| Spdconsult Ltd | Professional & scientific | 2024 |
| Speak OUT Revolution Ltd | Information & communication | 2020 |
| Speak Security Limited | Construction | 2006 |
| SPEAKS4ME Limited | Information & communication | 2009 |
| Speakup Self Advocacy Limited | Information & communication | 2003 |
| Special Alloys (Northern) Limited | Wholesale & retail | 1971 |
| Special Alloys Holdings Limited | Financial services | 1993 |
| Special Structures LAB. Limited | Professional & scientific | 1998 |
| Specialised Blade & Tool Limited | Manufacturing | 2012 |