| Solpropco Limited | Financial services | 2013 |
| Soul Sisters Holdings Limited | Wholesale & retail | 2025 |
| Southstore Ltd | Wholesale & retail | 2022 |
| Sovereign Advisory Group Ltd | Information & communication | 2026 |
| Sovereign Capital Wealth Management Ltd | Information & communication | 2026 |
| Spark Your Start Ltd | Health & social care | 2025 |
| Special Places Old Mill Ltd | Real estate | 2025 |
| Special Projects Group Ltd | Administrative & support | 2023 |
| Spectrum Inclusion CIC | Health & social care | 2024 |
| Spectrum of Light Rossendale C.I.C. | Other services | 2023 |
| Spectrum One Hair Extensions Ltd | Wholesale & retail | 2025 |
| Spectrum One Salon Group Limited | Other services | 2015 |
| SPG Electrics Ltd | Construction | 2015 |
| Spice Room Rossendale Limited | Financial services | 2019 |
| Spindle and Stone Holdings Ltd | Financial services | 2026 |
| Spirit Smith Ltd | Wholesale & retail | 2019 |
| Spirograph Limited | Administrative & support | 2017 |
| Sponsorbank Limited | Professional & scientific | 2004 |
| Sports Pitches Ltd | Construction | 2021 |
| Spray IT Services Ltd | Construction | 2017 |
| Springfield Drive Residents Association Limited | Households | 1995 |
| Springvale Leather Limited | Manufacturing | 1998 |
| Sprocket Motorcycles Limited | Wholesale & retail | 2020 |
| SPV 001 Ltd | Real estate | 2018 |
| SPV 003 Ltd | Real estate | 2018 |
| SQR YRD Ltd | Professional & scientific | 2025 |
| Squad Goals Global Ltd | Arts & recreation | 2022 |
| Squires Property Co Limited | Construction | 1995 |
| SR Electrical (Rossendale) Ltd | Construction | 2010 |
| SSE Driving Support Ltd | Transport & logistics | 2022 |
| SSH Asset Limited | Real estate | 2023 |
| SSL Transport Ltd | Transport & logistics | 2025 |
| ST Johns Court Ramsbottom Limited | Real estate | 2020 |
| Standard Wavelength Limited | Agriculture & fishing | 2015 |
| Stanislawscy Properties Ltd | Real estate | 2023 |
| Station Hotel Helmshore Limited | Hospitality | 2025 |
| Stephen Morley Associates Ltd | Public administration | 2025 |
| Steppingstones Leadership Development Limited | Professional & scientific | 2017 |
| Sterling Commercial Ltd | Wholesale & retail | 2015 |
| Sterling Holding Group Ltd | Financial services | 2026 |
| Sterling Metals Ltd | Wholesale & retail | 2017 |
| Sterling Square Ltd | Wholesale & retail | 2010 |
| Stewart & Co Property Specialists and Management Ltd | Real estate | 2025 |
| Stick With US Limited | Wholesale & retail | 2009 |
| Stikatak Limited | Professional & scientific | 1983 |
| Stoke Meals Club Ltd | Hospitality | 2024 |
| Stonecoat Limited | Construction | 2017 |
| Stonegate Technologies LLP | | 2012 |
| Storage & Offices Limited | Real estate | 2010 |
| Stoupa Ltd | Hospitality | 2019 |
| STP Investments Ltd | Financial services | 2017 |
| Strael Ltd | Information & communication | 2023 |
| Strongpod Ltd | Manufacturing | 2016 |
| Stubbs Group Ltd | Wholesale & retail | 2018 |
| Studio 51 Limited | Manufacturing | 2003 |
| Suave Aviation Ltd | Transport & logistics | 2024 |
| Suleman & Co Accountants Ltd | Professional & scientific | 2026 |
| Suleman Homes Ltd | Real estate | 2025 |
| Sun Fulfilment Limited | Transport & logistics | 2019 |
| Sun Home Gifts Limited | Wholesale & retail | 2020 |
| Sunderlands Travel Ltd | Administrative & support | 2002 |
| Sunnybank Developments Limited | Construction | 2009 |
| Supaplastics Limited | Construction | 2016 |
| Super Save Bargain Ltd | Wholesale & retail | 2019 |
| Supra Estates Limited | Real estate | 2025 |
| Supra Fast Food Supplies Ltd | Wholesale & retail | 2023 |
| Sustainable Closet Ltd | Wholesale & retail | 2022 |
| Sutcliffe's Electrical Contractors Ltd | Manufacturing | 2016 |
| Svlr Presentation Ltd | Administrative & support | 2024 |
| Swallow Tree Limited | Professional & scientific | 2024 |
| Sweeteas Bubble Tea Ltd | Hospitality | 2023 |
| Swift Private Hire Ltd | Administrative & support | 2024 |
| Swinton Leisure | Arts & recreation | 2012 |
| Switched on Electrical NW Ltd | Construction | 2017 |
| Switching Made Simple Ltd | Wholesale & retail | 2024 |
| SY Data Consultancy Limited | Information & communication | 2023 |
| Sykeside Court Management Company Limited | Professional & scientific | 2008 |
| Sykeside Leisure Limited | Hospitality | 2004 |
| Sympathetic Works Ltd | Construction | 2014 |
| T and J a Services Limited | Manufacturing | 2023 |
| T Brown Commercial Consultancy Ltd | Professional & scientific | 2023 |
| T Norton Limited | Wholesale & retail | 2026 |
| TAA NW Ltd | Health & social care | 2021 |
| Taas Estates Ltd | Real estate | 2025 |
| TAG Day Property Development Ltd | Real estate | 2025 |
| Talk Affiliates to ME Ltd | Professional & scientific | 2026 |
| TAM Medical Limited | Health & social care | 2025 |
| Tanning LAB Ltd | Other services | 2021 |
| Tasty Shawarma Limited | Hospitality | 2025 |
| Tasunke Consulting Ltd | Information & communication | 2025 |
| TAY N Sons Ltd | Hospitality | 2025 |
| Taylor Maid’S Cleaning & Care Ltd | Administrative & support | 2019 |
| Taylored Property Ventures Ltd | Real estate | 2025 |
| TBL Computer Solutions Limited | Information & communication | 2016 |
| TBM Ventures Ltd | Wholesale & retail | 2019 |
| TC Management Consultancy Services Ltd | Professional & scientific | 2014 |
| TCH Staffing Limited | Administrative & support | 2025 |
| Tchb Limited | Hospitality | 2023 |
| TCT Holdings Ltd | Wholesale & retail | 2022 |
| TDW Auto Electrics Ltd | Wholesale & retail | 2018 |