| S.E Scaffolding Ltd | Construction | 2023 |
| SA Kiran Takeaway Ltd | Hospitality | 2026 |
| SA Takeaway Ltd | Hospitality | 2026 |
| Saf.Mss Ltd | Wholesale & retail | 2026 |
| Safe Systems Cctv Ltd | Administrative & support | 2017 |
| Safia Locum Ltd | Health & social care | 2022 |
| Salesbench Limited | Professional & scientific | 2025 |
| Salt and Peppery Ltd | Hospitality | 2026 |
| Saluki Clinical Ltd | Health & social care | 2024 |
| SAN NW Limited | Health & social care | 2023 |
| Sandbird Ltd | Real estate | 2025 |
| Sapperfest CIC | Hospitality | 2012 |
| Sarah's Senco SOS Ltd | Education | 2026 |
| Sardar Mart Ltd | Wholesale & retail | 2026 |
| Sarwar Property Company Limited | Real estate | 2025 |
| Saurabh Resources Limited | Professional & scientific | 2013 |
| Saurabh Trading & Logistics Limited | Professional & scientific | 2013 |
| SAV 1 Limited | Hospitality | 2025 |
| Save Express Ltd | Financial services | 2020 |
| Save Payment UK Limited | Professional & scientific | 2019 |
| SB Decorating & Spraying Ltd | Construction | 2020 |
| SBC Stress Management Ltd. | Administrative & support | 2009 |
| SBK Properties (2025) Ltd | Construction | 2025 |
| Scan Accountancy Ltd | Professional & scientific | 2021 |
| SCC Furniture Limited | Manufacturing | 2022 |
| Schedule Four Consultancy LLP | | 2022 |
| Scope Technical Solutions Ltd | Construction | 2022 |
| Scotia Joinery Contractors Limited | Construction | 2005 |
| Scott Butterworth Onsite Machining Limited | Professional & scientific | 2006 |
| Sea CF Services Limited | Professional & scientific | 2013 |
| Sealed Systems Limited | Construction | 2025 |
| Secret Garden - Brandlesholme CIC | Education | 2022 |
| Secure Core Services Limited | Administrative & support | 2026 |
| Seema & Shakeel Ltd | Health & social care | 2015 |
| Selleu Limited | Manufacturing | 2017 |
| Seltech Engineering Services Ltd | Professional & scientific | 2024 |
| Send IT Leisure Ltd | Arts & recreation | 2026 |
| Serenity Reset CIC | Education | 2025 |
| Setting Sons Holdings Limited | Financial services | 2022 |
| SF Medics Limited | Health & social care | 2022 |
| SFX101 Ltd | Other services | 2024 |
| SH Residential Ltd | Real estate | 2017 |
| Shaks Logistics Ltd | Transport & logistics | 2024 |
| Sharpskill Engineering Limited | Administrative & support | 2005 |
| Shawbrook Motors Ltd | Wholesale & retail | 2019 |
| Shear Limited | Professional & scientific | 2006 |
| Shepherd's Inn Rossendale Limited | Hospitality | 2015 |
| Sherridge Heating and Plumbing Ltd | Construction | 2025 |
| Shomoy Ltd | Real estate | 2022 |
| Shredco Ltd | Administrative & support | 2021 |
| Shredco UK Ltd | Extraterritorial | 2022 |
| Shree Ganesh KD Ltd | Real estate | 2020 |
| Sicad Design Limited | Professional & scientific | 2017 |
| Simbioze Football Team Ltd | Administrative & support | 2026 |
| Simco Building Services Limited | Construction | 2023 |
| Simply Annuities Limited | Extraterritorial | 2024 |
| Simply Financial Solutions Limited | Real estate | 2018 |
| Simply Flowers (Rochdale) Limited | Wholesale & retail | 2009 |
| Simply Therapies Limited | Health & social care | 2018 |
| Simply Therapy and Rehab Ltd | Health & social care | 2020 |
| SIR Render Ltd | Construction | 2025 |
| SJ Safety & Management System Solutions Limited | Professional & scientific | 2022 |
| SJB Fresh Food Ltd | Hospitality | 2026 |
| SJR Growth Consultancy Ltd | Professional & scientific | 2022 |
| SK Business Advisory Limited | Professional & scientific | 2026 |
| SK Marketing Solutions Ltd | Professional & scientific | 2020 |
| SK Mitchell Property Limited | Real estate | 2023 |
| SKH Plumbing & Heating Ltd | Construction | 2011 |
| SKI Rossendale Limited | Arts & recreation | 2011 |
| Skin Address Ltd | Health & social care | 2022 |
| SKS Property Investments & Rentals Limited | Households | 2025 |
| Sky Hand Car Wash Ltd | Administrative & support | 2017 |
| Skyline Engineering & Surveys Ltd | Construction | 2020 |
| Skywish Traders Ltd | Wholesale & retail | 2025 |
| Slater Brooking Lettings Ltd | Real estate | 2024 |
| Slater Brooking Limited | Real estate | 2023 |
| SLC NW Management Limited | Hospitality | 2026 |
| SLM Performance Ltd | Arts & recreation | 2017 |
| Sloth Supplies Ltd | Wholesale & retail | 2026 |
| SM Chambers Ltd | Arts & recreation | 2019 |
| SM102 | Professional & scientific | 2009 |
| Smart Finds Direct Ltd | Wholesale & retail | 2018 |
| Smash Stop Ltd | Hospitality | 2025 |
| Smethurst Automation Ltd | Information & communication | 2022 |
| SMH Joinery and Building Ltd | Construction | 2023 |
| Smith Taylor Associates Limited | Financial services | 2024 |
| Smithvalley Engineering Ltd | Manufacturing | 2023 |
| SMK Coaching and Consultancy Limited | Professional & scientific | 2025 |
| SMS786 Ltd | Wholesale & retail | 2026 |
| Smwestates Limited | Real estate | 2012 |
| Snack Station Vending Limited | Wholesale & retail | 2025 |
| SNG Hospitality Limited | Hospitality | 2026 |
| Snoop Rail Limited | Construction | 2017 |
| Snoutin' About Ltd | Wholesale & retail | 2026 |
| Sofa Cycle Ltd. | Wholesale & retail | 2016 |
| Solarluxe UK Ltd | Construction | 2024 |
| Solaronetech Limited | Construction | 2026 |
| Solcomm Limited | Financial services | 2013 |
| Solis Running Ltd | Manufacturing | 2025 |
| Solomon Commercials Limited | Manufacturing | 1981 |