| Dasic International Aerospace Limited | Wholesale & retail | 2014 |
| Dasic International Holdings Limited | Financial services | 2022 |
| Dasic International Limited | Manufacturing | 1986 |
| Dasic International OSD Limited | Wholesale & retail | 2014 |
| Dasic Property Holdings Limited | Financial services | 2022 |
| Dasset Labs Ltd | Professional & scientific | 2021 |
| Data Working Ltd | Information & communication | 2016 |
| Datastream Consulting Limited | Information & communication | 2025 |
| David Breach Limited | Professional & scientific | 2004 |
| David Butler Ltd | Agriculture & fishing | 2018 |
| David Cook Physiotherapy Limited | Health & social care | 2010 |
| David Higgs Consultancy Limited | Health & social care | 2022 |
| David Hinsley Limited | Health & social care | 2013 |
| David Hornsey Motorsport Limited | Arts & recreation | 2015 |
| David Management Tadburn Limited | Households | 1974 |
| David Salter Flowers Limited | Wholesale & retail | 2012 |
| David Salter Wholesale Flowers Limited | Wholesale & retail | 2020 |
| Dawnthrive Limited | Wholesale & retail | 1986 |
| DC Building & Extensions Ltd. | Construction | 2017 |
| DC Scaffolding Services Ltd | Construction | 2025 |
| DC TV Limited | Manufacturing | 2003 |
| DCD Fencing Ltd | Construction | 2014 |
| DCR Ortho Limited | Health & social care | 2019 |
| Ddbo Global Limited | Real estate | 2020 |
| DDS Medical Services Limited | Health & social care | 2012 |
| Dead Head Promotions Ltd | Arts & recreation | 2026 |
| Deam Medical Consultancy Ltd | Health & social care | 2025 |
| Defero Communications Ltd | Professional & scientific | 2010 |
| DEL REY UK Limited | Extraterritorial | 2020 |
| Delofa Living Ltd | Wholesale & retail | 2025 |
| Delofa Ltd | Wholesale & retail | 2025 |
| Denali Finance Limited | Professional & scientific | 2018 |
| Deon Design Limited | Information & communication | 2015 |
| Deos Group Holdings Limited | Financial services | 2021 |
| Deos Group.Co.Uk Limited | Administrative & support | 2017 |
| Derc Transport Ltd | Transport & logistics | 2022 |
| Dernthom Limited | Extraterritorial | 2017 |
| Design and Made UK Ltd | Wholesale & retail | 2024 |
| Designs Drawn Ltd | Professional & scientific | 2006 |
| Devereux Hair and Beauty Ltd | Other services | 2019 |
| DEW Associates LLP | | 2015 |
| Dexell Limited | Wholesale & retail | 1993 |
| DG Scaffolding Limited | Construction | 2025 |
| DH Wise Analytics Ltd | Financial services | 2025 |
| DHR Technology Ltd | Information & communication | 2017 |
| Diamond Courier Services Ltd | Transport & logistics | 2017 |
| Diamond Print and Mail Centre C.I.C. | Administrative & support | 2011 |
| Digital 5 Ltd | Professional & scientific | 2025 |
| Digital Spark Ltd | Information & communication | 2020 |
| DIRECT4LOGOS Ltd | Wholesale & retail | 2013 |
| Disgrace Limited | Information & communication | 2025 |
| Disintermediate Ltd | Information & communication | 2021 |
| Divo Welding Services Limited | Manufacturing | 2014 |
| Dixey Holdings Limited | Financial services | 2025 |
| Dixeyclean Limited | Administrative & support | 2015 |
| DJ Detailing Ltd | Administrative & support | 2025 |
| DJB Construction South Limited | Construction | 2011 |
| DMK Care and Support Ltd | Administrative & support | 2022 |
| DMS Technologies Ltd | Extraterritorial | 1988 |
| DOC Medical Services Limited | Health & social care | 2018 |
| Docom Limited | Education | 2014 |
| Doctor VEE Ltd | Education | 2025 |
| Doctorash Medics LLP | | 2025 |
| Dodimead Consulting Limited | Information & communication | 2007 |
| Domelins Limited | Professional & scientific | 2011 |
| DON Hobbs Preservation Limited | Construction | 2012 |
| Doncaster Waterfront Limited | Construction | 2024 |
| Donovan Napier Taylor Limited | Professional & scientific | 2022 |
| Dorchester Anaesthetists LLP | | 2013 |
| Dorchester Surgical Services Ltd | Health & social care | 2021 |
| Dorset EAR Nose & Throat Limited | Health & social care | 2010 |
| Dorset Knee Clinic Limited | Health & social care | 2009 |
| Dorset Knee Specialist Limited | Health & social care | 2022 |
| Dorset Medical & Legal Services Limited | Health & social care | 2009 |
| Dorset Orthopaedic Consultant Services LLP | | 2017 |
| Dorset Private GP Ltd | Health & social care | 2019 |
| Dorset Radiologist Limited | Health & social care | 2019 |
| Dorset Urology Limited | Health & social care | 2011 |
| Doublejay Logistics Limited | Transport & logistics | 2015 |
| Dove on the River Ltd | Hospitality | 2026 |
| Downfield Estates Limited | Real estate | 2018 |
| DOX Centre Limited | Other services | 2019 |
| DOX PCS Ltd | Other services | 2022 |
| DR Anna Morris Haematologist Limited | Health & social care | 2023 |
| DR David Shearn Limited | Health & social care | 2024 |
| DR Michael Griksaitis Limited | Health & social care | 2024 |
| DR MJ Knight Limited | Health & social care | 2022 |
| DR Rosie Kalsi Ltd | Health & social care | 2024 |
| DR Vegan Ltd | Wholesale & retail | 2020 |
| DR. MAX Jonas Limited | Health & social care | 2002 |
| Dragon Medical Consultancy LLP | | 2024 |
| Dreamy Dwellings Ltd | Extraterritorial | 2023 |
| Drft Ltd | Wholesale & retail | 2026 |
| Drivedata UK Ltd | Manufacturing | 2002 |
| Drove Developments Ltd | Construction | 2024 |
| Drove Solutions Limited | Construction | 2014 |
| Drummond Heating Ltd. | Manufacturing | 2011 |
| DRW Property (South) Limited | Real estate | 2018 |
| Dryad Tree Specialists Limited | Agriculture & fishing | 2007 |
| DS Lasers Limited | Health & social care | 2022 |