| Selle Cases Ltd | Wholesale & retail | 2025 |
| Selleholic Ltd | Wholesale & retail | 2025 |
| Seller Copilot Ltd | Information & communication | 2026 |
| Sellfmarket Ltd | Wholesale & retail | 2022 |
| Sellyourcarnow Limited | Wholesale & retail | 2025 |
| Sellz Global Limited | Wholesale & retail | 2021 |
| Selsdon Builders Ltd | Construction | 2025 |
| Selvey Holdings Ltd | Wholesale & retail | 2023 |
| SEM Buses Ltd | Transport & logistics | 2018 |
| Semaphore Property Limited | Real estate | 2016 |
| Semblance Aesthetics Ltd | Health & social care | 2022 |
| Sempre Properties Limited | Real estate | 2021 |
| SEN Medical Services Limited | Health & social care | 2021 |
| SEN World Ltd | Education | 2021 |
| Send Tuition Support Ltd | Education | 2025 |
| Senegal Fish Ltd | Wholesale & retail | 2025 |
| Senko AB Limited | Education | 2018 |
| Sense IT London Ltd | Professional & scientific | 2022 |
| Sensible Cooling Limited | Construction | 2019 |
| Sensory Seekerz Ltd | Arts & recreation | 2024 |
| Sensory Visionaries Limited | Professional & scientific | 2017 |
| Sentinel Defense Limited | Administrative & support | 2025 |
| Senzu Solutions Ltd | Information & communication | 2012 |
| Seratec Limited | Information & communication | 2022 |
| Seravita Luxe Ltd | Real estate | 2025 |
| Serena-Hope Ltd | Health & social care | 2025 |
| Serendipity Homecare Ltd | Health & social care | 2026 |
| Serene Homes London Limited | Real estate | 2025 |
| Serene Mews (Romford) Management Limited | Households | 2012 |
| Serenia Solutions Limited | Public administration | 2022 |
| Serenity - Aesthetics, Skin, Health and Wellbeing Ltd | Other services | 2022 |
| Serenity Options Ltd | Health & social care | 2022 |
| Serenity Supported Care Ltd | Health & social care | 2024 |
| Serenvi Ltd | Health & social care | 2024 |
| Serge Barbers Limited | Other services | 2023 |
| Serina LYN Therapy Ltd | Other services | 2021 |
| Serious Intentions Ltd | Education | 2007 |
| Serket Limited | Wholesale & retail | 2023 |
| Serpo Ltd | Transport & logistics | 2021 |
| Serv Provider Limited | Construction | 2025 |
| Serve Delight Ltd | Hospitality | 2017 |
| Servetrans Limited | Information & communication | 2013 |
| Services Global Ltd | Administrative & support | 2011 |
| Serving Vrindavan Ltd | Health & social care | 2017 |
| Servion IT Resourcing Ltd | Professional & scientific | 2017 |
| Servomach Systems Limited | Information & communication | 2023 |
| Serwaapa Limited | Administrative & support | 2022 |
| Serzan Barber Limited | Other services | 2022 |
| SES Employee Solutions Ltd | Administrative & support | 2025 |
| Sesh Culture Ltd | Wholesale & retail | 2023 |
| Sesm Property Ltd | Real estate | 2021 |
| SET Protect Ltd | Administrative & support | 2022 |
| Setll Care Services Ltd | Health & social care | 2024 |
| Setwin Ltd. | Manufacturing | 2013 |
| Seven Kings Builders Ltd | Construction | 2026 |
| Seven Tudor Ltd | Real estate | 2016 |
| Seventh Wonder Surveyors Ltd | Construction | 2011 |
| Sexidrink Limited | Manufacturing | 2025 |
| SEY Estates Ltd | Real estate | 2025 |
| SF Concessionaire Ltd | Wholesale & retail | 2024 |
| SF Musical UK Ltd | Arts & recreation | 2025 |
| SFA & Co. Ltd | Professional & scientific | 2008 |
| Sfaet Ltd | Education | 2011 |
| Sfezi Group Ltd | Information & communication | 2025 |
| Sfincione Ltd | Hospitality | 2020 |
| SFM Group Ltd | Real estate | 2015 |
| SG & SV Holdings Ltd | Financial services | 2025 |
| SG Dental Services Ltd | Health & social care | 2022 |
| SG Kirpa Limited | Real estate | 2024 |
| SGA Property Solutions Limited | Construction | 2022 |
| SGB Creations Limited | Construction | 2025 |
| SGD Logistics Ltd | Wholesale & retail | 2026 |
| SGH London Ltd | Construction | 2023 |
| Sgim Property Maintenance Ltd | Construction | 2024 |
| SGJ Builders Ltd | Construction | 2019 |
| SGM Cleaning & Maintenance Ltd | Administrative & support | 2026 |
| Sgsg Consultancy Ltd | Professional & scientific | 2024 |
| SH Housing CIC | Health & social care | 2024 |
| Shaaz Ltd | Extraterritorial | 2022 |
| Shaded Hues Ltd | Wholesale & retail | 2024 |
| Shades by Woodpecker Ltd | Wholesale & retail | 2021 |
| Shades of Melanin.Com Limited | Health & social care | 2021 |
| Shadija Assets & Management Ltd | Real estate | 2023 |
| Shadija Limited | Financial services | 2023 |
| Shadow Legacy Trading Ltd | Transport & logistics | 2024 |
| Shadowline Developments and Consultancy Ltd | Professional & scientific | 2023 |
| Shah Design & Construction Ltd | Construction | 2024 |
| Shahh Properties Ltd | Real estate | 2025 |
| Shahjalal Store Limited | Wholesale & retail | 2024 |
| Shahnanak Investment Ltd | Real estate | 2021 |
| Shahu Build Ltd | Construction | 2025 |
| Shajai Ecomm Limited | Wholesale & retail | 2025 |
| Shajai Limited | Information & communication | 2015 |
| Shake Limited | Information & communication | 2026 |
| Shalom Ventures Ltd | Real estate | 2025 |
| Shama's Centre IU Ltd | Wholesale & retail | 2024 |
| Shamim Consultancy Ltd | Administrative & support | 2025 |
| Shamji Holdings Ltd | Health & social care | 2020 |
| Shammah Consultancy Limited | Professional & scientific | 2022 |
| Shamz N Co Ltd. | Construction | 2016 |