| Sovereign Sports Limited | Construction | 2017 |
| Sovereignty Estates Limited | Real estate | 2024 |
| Sovereignty Investments Limited | Real estate | 2024 |
| Sovereignty Property Limited | Real estate | 2024 |
| Space Electrical Management Ltd | Construction | 2011 |
| Space Innovation Services Ltd | Construction | 2017 |
| Space JAX Play Centre Limited | Health & social care | 2025 |
| Spacescruff Limited | Wholesale & retail | 2024 |
| Spaghetti Weston Limited | Information & communication | 2008 |
| Sparkbloc Limited | Real estate | 2024 |
| Sparkling Hand Car Wash Ltd | Other services | 2017 |
| Spartan Industries Ltd | Wholesale & retail | 2025 |
| Spec Properties Ltd | Real estate | 2021 |
| Special Events Hire Limited | Transport & logistics | 2022 |
| Special Purpose Properties Ltd | Real estate | 1984 |
| Specialist Building and Roofing Limited | Construction | 2025 |
| Specialty Powders Holdings Limited | Manufacturing | 2010 |
| Specs Rigging Ltd | Construction | 2014 |
| Spectrum Sound Ltd | Information & communication | 2026 |
| Speedy 1 Tyres Limited | Wholesale & retail | 2024 |
| Speldhurst Preschool Limited | Health & social care | 2015 |
| Spembly Limited | Real estate | 2020 |
| Spenda Finance Ltd | Wholesale & retail | 2017 |
| Spendmuchless Ltd | Wholesale & retail | 2023 |
| Spicy Kitchen (HOO) Limited | Hospitality | 2019 |
| Spike Repairs Limited | Wholesale & retail | 2012 |
| Spikes Consultancy Ltd | Professional & scientific | 2023 |
| Spinksies Tyres Ltd | Wholesale & retail | 2019 |
| SPK Holdings Limited | Construction | 2020 |
| SPK Ventures Ltd | Financial services | 2020 |
| Splash Shelf Ltd | Wholesale & retail | 2025 |
| Splinters Display Ltd | Construction | 2016 |
| Sport Global Management Limited | Professional & scientific | 2026 |
| Spotless Sanctuary Cleaners Limited | Administrative & support | 2025 |
| Spotlex Ltd | Other services | 2018 |
| Sprout to Sparkle CIC | Health & social care | 2025 |
| SPV Insights Limited | Professional & scientific | 2021 |
| Square Care Ltd | Health & social care | 2023 |
| Squires Bespoke Builds Limited | Construction | 2025 |
| Squirrell Engineering Ltd | Construction | 2015 |
| Sr&R Coded Welding & Fabrication Ltd | Manufacturing | 2024 |
| SRB Construction Solutions Ltd | Construction | 2018 |
| SRB Installation Projects Limited | Professional & scientific | 2020 |
| Srushti Limited | Wholesale & retail | 2015 |
| SS Investing Ltd. | Real estate | 2025 |
| SS Podiatry Ltd | Public administration | 2025 |
| Ssdr Distribution Ltd | Wholesale & retail | 2025 |
| SSE ODO Limited | Real estate | 2017 |
| Ssignatures Realtors Ltd | Real estate | 2021 |
| Sslb Consulting Limited | Professional & scientific | 2015 |
| Sslb Properties Ltd | Real estate | 2023 |
| Sslw Properties Limited | Real estate | 2021 |
| ST Andrews Aqua Park Ltd | Arts & recreation | 2021 |
| ST Andrews Commercial Land Limited | Construction | 2017 |
| ST Andrews Leisure Development Ltd | Construction | 2016 |
| ST Andrews Leisure Management Ltd | Professional & scientific | 2016 |
| ST Edwards Capital (Freehold) Limited | Households | 2025 |
| ST Edwards Capital Limited | Real estate | 2016 |
| ST Finn. Land Works & Machine Supply Limited | Construction | 2018 |
| ST George Asset Management Limited | Households | 2024 |
| ST George Capital (Land) Limited | Real estate | 2025 |
| ST Louis Media Services Limited | Information & communication | 2019 |
| ST Lukes Pre-School (Rochester) | Education | 2003 |
| St-Electrical Installations Ltd | Construction | 2022 |
| ST. Andrews Leisure Limited | Administrative & support | 2016 |
| ST. Catherines Court Star Hill Limited | Households | 2002 |
| ST. Marguerite Residential Care Home Ltd | Households | 2003 |
| Stable Contracts Limited | Administrative & support | 2000 |
| Staco Gratings UK Ltd | Other services | 2004 |
| Staffing Centre Limited | Administrative & support | 2024 |
| Stag Holdings (Maidstone) Ltd | Real estate | 2016 |
| Stag Holdings Limited | Real estate | 2021 |
| Stag Interiors Ltd | Construction | 2019 |
| Stage Acting Studio Ltd | Arts & recreation | 2026 |
| Stanbo Electrical Ltd | Construction | 2024 |
| Standard Apex Services Limited | Other services | 2000 |
| Standard Fire Limited | Public administration | 2026 |
| Stanhill Estate Limited | Construction | 2017 |
| Staples Jewellery Limited | Manufacturing | 2022 |
| Star Financial Solutions Limited | Financial services | 2010 |
| Star Shine Therapies Limited | Health & social care | 2023 |
| Stare Technologies Ltd | Information & communication | 2026 |
| Starfish Entertainments (UK) Limited | Arts & recreation | 1998 |
| Starnow Ltd | Information & communication | 2022 |
| Start to Finish Builders Ltd | Construction | 2015 |
| Status Financial Services Limited | Financial services | 2014 |
| Stay Young Aesthetics Ltd | Other services | 2023 |
| Steadfast Law Limited | Professional & scientific | 2010 |
| Steadfast Property Services Ltd | Construction | 2024 |
| Steady Paths Care Ltd | Health & social care | 2025 |
| Steak and Cakes Ltd | Hospitality | 2019 |
| Stech Care Limited | Health & social care | 2024 |
| Steel Core Dinamycs Ltd | Construction | 2026 |
| Stelko 85 Ltd | Transport & logistics | 2020 |
| Stem Top Grades Ltd | Information & communication | 2026 |
| Stematrix Education Limited | Education | 2017 |
| Stemi Limited | Health & social care | 2023 |
| Stemkent Ltd | Education | 2010 |
| Step Homes & Living Limited | Real estate | 2019 |
| Stephens Fresh Foods Limited | Manufacturing | 1987 |