| Scruffy Bubble CIC | Education | 2021 |
| SCS (South East) Limited | Construction | 2019 |
| SCS Heating Ltd | Other services | 2013 |
| Scuff Doctor EV Limited | Construction | 2024 |
| Scuff Doctor Ltd | Manufacturing | 2008 |
| SD Convenience Store Ltd | Wholesale & retail | 2025 |
| SD Harrison Services Ltd | Construction | 2024 |
| SDE Creations Ltd | Construction | 2022 |
| SDG Mechanical Services Ltd | Administrative & support | 2017 |
| SDL Carpentry and Joinery Limited | Manufacturing | 2022 |
| SDM Resource Ltd | Professional & scientific | 2007 |
| SDW Electrical Services Limited | Construction | 2013 |
| SE Rigging Ltd | Administrative & support | 2021 |
| SE9 Security Ltd | Administrative & support | 2024 |
| Sea of C’S Ltd | Wholesale & retail | 2025 |
| Seal Bespoke Carpentry Limited | Manufacturing | 2025 |
| Seal Business Consulting UK Ltd | Information & communication | 2025 |
| Sealrite Limited | Manufacturing | 2004 |
| SEARCH3PL Ltd | Information & communication | 2025 |
| Sebalex Cabling Solutions Ltd | Information & communication | 2019 |
| Sechko Group Limited | Transport & logistics | 2026 |
| Second ACT Advisory Studio Ltd | Professional & scientific | 2026 |
| Secondvolt Ltd | Construction | 2026 |
| Security Installation Services Limited | Other services | 1993 |
| Seddle Limited | Real estate | 2026 |
| Sedidun Edibles Limited | Manufacturing | 2026 |
| Segment Timepieces Ltd | Wholesale & retail | 2021 |
| Sekha Limited | Professional & scientific | 2021 |
| Selby & Sons Construction Ltd | Administrative & support | 2011 |
| Selfdrive Ltd | Extraterritorial | 2021 |
| Semple Gardens Management Limited | Households | 1997 |
| Senergi Ltd | Other services | 2023 |
| Sengdaophet Ventress Limited | Wholesale & retail | 2022 |
| Senter Light Childcare Limited | Education | 2023 |
| Sentinel Auto Security Ltd | Construction | 2023 |
| SER Building Contractors Ltd | Construction | 2025 |
| Serendib Lettings Ltd | Real estate | 2022 |
| Serendipity Body Piercing Limited | Other services | 2020 |
| Serenity & Co. Limited | Hospitality | 2012 |
| Serenity Homes Care UK Ltd | Health & social care | 2024 |
| Serenity Lettings Ltd | Real estate | 2017 |
| Serhill Ltd | Wholesale & retail | 2023 |
| Service Nation UK Ltd | Manufacturing | 2023 |
| Service- Options Limited | Health & social care | 2018 |
| SET to Success Ltd | Professional & scientific | 2023 |
| Seunjay Healthcare Limited | Health & social care | 2018 |
| Seven Chakras Limited | Arts & recreation | 2013 |
| Sevenoaks Plans and Development Ltd | Professional & scientific | 2016 |
| Sevenoaks Plans Ltd | Professional & scientific | 2013 |
| SEW in Kent Limited | Wholesale & retail | 2022 |
| Sewanu Ltd | Real estate | 2022 |
| SFK Traders Ltd | Wholesale & retail | 2023 |
| SFR Developments Kent LLP | | 2019 |
| SG Mortgage & Financial Services Ltd | Financial services | 2026 |
| SG Security Systems Limited | Administrative & support | 2021 |
| SGD Consulting Services Ltd | Professional & scientific | 2026 |
| SGS Accountants Limited | Professional & scientific | 2014 |
| SGT Service Providers Limited | Health & social care | 2016 |
| SH Joinery Kent Ltd | Construction | 2025 |
| SH Plumbing Ltd | Construction | 2022 |
| SHA Masala Ltd | Hospitality | 2024 |
| Shaan Bhangre DI Ltd | Arts & recreation | 2026 |
| Shade Elizabeth Consultancy Ltd | Information & communication | 2026 |
| Shadyblue Ltd | Information & communication | 2016 |
| Shahanara Curry House Ltd. | Hospitality | 2018 |
| Shai Vision Ltd | Professional & scientific | 2016 |
| Shakehands Limited | Real estate | 2017 |
| Shallow Bay Media Ltd | Information & communication | 2023 |
| Shalom Construction Ltd | Administrative & support | 2015 |
| Shan C Renewables Limited | Construction | 2025 |
| Shane Stoten Ltd | Construction | 2025 |
| Shannon Access Solutions Ltd | Construction | 2018 |
| Shape by Nards Ltd | Health & social care | 2026 |
| Shape Nail Studio Ltd | Other services | 2025 |
| Shared Times Limited | Administrative & support | 2016 |
| Shark Secure Ltd | Construction | 2025 |
| Sharmas Tuition Limited | Education | 2023 |
| Sharn Bakes Cakes Ltd | Manufacturing | 2024 |
| Sharp Advantage Consulting Ltd | Professional & scientific | 2012 |
| Sharp Fire Protection Ltd | Public administration | 2023 |
| Sharp Services Limited | Construction | 2015 |
| Shawn N Shane Properties Ltd | Real estate | 2019 |
| SHB Tyres Ltd | Wholesale & retail | 2024 |
| SHD Scaffold Rigging Ltd | Construction | 2025 |
| Sheengold Limited | Financial services | 2002 |
| Sheerness Port Services Limited | Transport & logistics | 2012 |
| Shekynah Corporation Ltd | Other services | 2017 |
| Shell-Ter Limited | Real estate | 2019 |
| Shem Chauffeur Ltd | Transport & logistics | 2015 |
| Shenapharm Limited | Professional & scientific | 2019 |
| Shepherd Towry Limited | Real estate | 2023 |
| Sheppard Associates Ltd | Public administration | 2016 |
| Sheppards Property Services Ltd | Administrative & support | 2020 |
| Sheps Property Ltd | Real estate | 2025 |
| Shergill Building Solutions Ltd | Construction | 2024 |
| Sheriff Locks Ltd. | Construction | 2015 |
| Sherridales Group Limited | Construction | 2023 |
| Sherwood Accountancy Services Limited | Professional & scientific | 2014 |
| Sherwood Carpentry Services Limited | Administrative & support | 2007 |
| Shid Health Care Limited | Health & social care | 2015 |