| S&Fl Services Ltd | Construction | 2018 |
| S&G Communications Ltd | Information & communication | 2022 |
| S&H Solutions Ltd | Real estate | 2019 |
| S&J Motor Vehicles Ltd | Wholesale & retail | 2025 |
| S&K Precision Projects Ltd | Construction | 2021 |
| S&N Property Services (London) Ltd | Real estate | 2013 |
| S.A Movement Ltd | Arts & recreation | 2024 |
| S.C. Lindridge Building Services Limited | Construction | 2006 |
| S.D. Autocare and Repair Ltd. | Wholesale & retail | 2012 |
| S.H.G Scaffoldrigging Limited | Construction | 2023 |
| S.L.R Crystals Ltd | Wholesale & retail | 2026 |
| S.M.E Wired (Consultancy Services) Limited | Professional & scientific | 2025 |
| S.P. Firmin Limited | Construction | 2017 |
| S.Richards Scaffolding Limited | Construction | 2016 |
| S1 Southeast Maintenance Ltd | Construction | 2026 |
| S2 South East Ltd | Real estate | 2019 |
| SA Holistic Wellbeing and Solution Ltd | Health & social care | 2026 |
| Sa-Muwo Ltd | Public administration | 2021 |
| Sada Shukar Ltd | Real estate | 2025 |
| Sade Rose Consulting Ltd | Professional & scientific | 2024 |
| Safe and Empowered CIC | Education | 2026 |
| Safe Excavation Ltd | Administrative & support | 2016 |
| Safe Hub Care Ltd | Health & social care | 2023 |
| Safe Scaffolding Limited | Construction | 2014 |
| Safer Medway Limited | Other services | 2006 |
| Safetime Holdings Limited | Financial services | 2024 |
| Safetime Limited | Information & communication | 2013 |
| Safetime Property Limited | Real estate | 2024 |
| Safetycraft Ltd | Professional & scientific | 2024 |
| Safio Limited | Professional & scientific | 2018 |
| Saga Fashions Limited | Manufacturing | 1995 |
| Sagash Ltd | Wholesale & retail | 2017 |
| Saglam Accounting & Bookkeeping Limited | Professional & scientific | 2026 |
| Saha Limited | Professional & scientific | 2008 |
| Sahara Wellbeing CIC | Health & social care | 2025 |
| Saharai Ltd | Real estate | 2023 |
| Saintoware Limited | Construction | 2022 |
| Saints Business Consultancy Ltd | Professional & scientific | 2007 |
| Sajji Holdings Limited | Financial services | 2016 |
| Salisbury House Management (Gillingham) Limited | Real estate | 2009 |
| SAM & MIR Contractor Ltd | Construction | 2022 |
| SAM Facilities Limited | Administrative & support | 2020 |
| SAM Wadds Water Services Limited | Construction | 2026 |
| Samantha Thomas Elite Ltd | Other services | 2017 |
| Sams Associates Ltd | Transport & logistics | 2026 |
| Samuel Boden Limited | Arts & recreation | 2014 |
| Sanc Ltd | Hospitality | 2025 |
| Sandpiper Brooks Ltd | Real estate | 2023 |
| Sandyz Bridal Boutique Ltd | Wholesale & retail | 2018 |
| Sangat Maan Co Ltd | Administrative & support | 2023 |
| Sangha Property Group Ltd | Real estate | 2024 |
| Sanmax Ltd | Transport & logistics | 2019 |
| Sanmukh Care Ltd | Health & social care | 2021 |
| Sant OZ Limited | Wholesale & retail | 2024 |
| Santone Carpets Limited | Administrative & support | 2003 |
| Santos Engineering Limited | Professional & scientific | 2014 |
| Sapientia Consulting Limited | Financial services | 2015 |
| Sapor (Holdings) Limited | Wholesale & retail | 2019 |
| Sara (PVT) Ltd | Wholesale & retail | 2021 |
| Sarah Massiah Presents the Golden Keys From Melchizedek Ltd | Health & social care | 2019 |
| Sarah's Ventures Limited | Health & social care | 2018 |
| Sarakuna Consultancy Ltd | Transport & logistics | 2017 |
| Saran Accountants & Business Solutions Ltd. | Professional & scientific | 2014 |
| Saraphina Ltd | Health & social care | 2025 |
| Sarkariya Investment Group Limited | Real estate | 2022 |
| Sarkariya Ltd | Professional & scientific | 2021 |
| Sarsub Limited | Manufacturing | 2023 |
| SAS Brother's Rasoi Ltd | Hospitality | 2023 |
| Savvy FOX Limited | Administrative & support | 2018 |
| Saward Group Ltd | Professional & scientific | 2023 |
| Saward Tipping Services Limited | Transport & logistics | 1999 |
| Saxon House Developments Ltd | Construction | 2025 |
| Saxon LG Limited | Construction | 2025 |
| SB Cars and Valets Ltd | Wholesale & retail | 2022 |
| SB Investment Property Ltd | Real estate | 2021 |
| SB Retail Ltd | Wholesale & retail | 2022 |
| Sbgm Procurement Limited | Information & communication | 2026 |
| Sbmg Logistics Limited | Transport & logistics | 2026 |
| SBS Dive Limited | Professional & scientific | 2017 |
| SBY Services Ltd | Manufacturing | 2024 |
| SC & JC Services LLP | | 2023 |
| Scaffdeck Ltd | Manufacturing | 2025 |
| Scaffold Access Supplies Ltd | Manufacturing | 2020 |
| Scallywags (Medway) Limited | Health & social care | 2012 |
| Sccc Trading Ltd | Wholesale & retail | 2026 |
| Sceptre Links Limited | Administrative & support | 2007 |
| Scmc Property Development Ltd | Construction | 2019 |
| Scoff & SIP (Kent) Ltd | Hospitality | 2021 |
| Scoff and SIP Holdings Ltd | Financial services | 2026 |
| Scoff and SIP Ltd | Hospitality | 2026 |
| Scogis Consulting Limited | Professional & scientific | 2024 |
| Scoreclub Limited | Financial services | 2018 |
| Scott & Dani Ltd | Wholesale & retail | 2023 |
| Scott Care Limited | Health & social care | 2004 |
| Scott Robert James Taylor Limited | Professional & scientific | 2018 |
| Scott's Estate Management Limited | Households | 2025 |
| Scotts Elevators Ltd | Construction | 2020 |
| Screed Factory Ltd | Construction | 2024 |
| Screedfast Limited | Construction | 2017 |
| Screeding UK Ltd | Construction | 2020 |