| Seekh Kebab Ltd | Hospitality | 2019 |
| Seeking Goods Ltd | Wholesale & retail | 2025 |
| Seeros Daycare Nursery Ltd | Health & social care | 2009 |
| SEJ Marketing Ltd | Professional & scientific | 2025 |
| Select 2 Buy Ltd | Wholesale & retail | 2024 |
| Sellars Construction Limited | Construction | 2010 |
| Selloria Wholesale Ltd | Wholesale & retail | 2021 |
| Selwa & Co Ltd | Households | 2025 |
| Semhar Ltd | Health & social care | 2023 |
| Semper Blinds Direct Limited | Wholesale & retail | 2020 |
| Semper Blinds Ltd | Extraterritorial | 2015 |
| Semper Roof Blind Systems Ltd | Manufacturing | 2015 |
| Sense Path Ltd | Information & communication | 2024 |
| Sentech Systems Ltd | Manufacturing | 2018 |
| Sentiment Tattoo Ltd | Other services | 2015 |
| Sentinel Protection Services Group Limited | Transport & logistics | 2023 |
| Sentinel Solutions Ltd | Professional & scientific | 2023 |
| Sequoia E-Commerce Ltd | Wholesale & retail | 2026 |
| Seraphia Ltd | Wholesale & retail | 2025 |
| Seraphic Property Management Ltd | Real estate | 2024 |
| Seremaci Ltd | Mining & quarrying | 2022 |
| Serene Care Solutions Limited | Administrative & support | 2022 |
| Serene Sleep Group Ltd | Wholesale & retail | 2026 |
| Seriki Handyman General Services Limited | Construction | 2025 |
| Serious Brewing Company Ltd | Manufacturing | 2015 |
| Serve IQ Ltd | Information & communication | 2025 |
| Server Suggest UK Ltd | Wholesale & retail | 2025 |
| Service Properties Ltd | Hospitality | 2021 |
| Serviceai Ltd | Information & communication | 2025 |
| Serving Humanitee CIC | Health & social care | 2022 |
| SET2 Ltd | Other services | 2017 |
| Seven Aces Aggregates Ltd | Construction | 2024 |
| Seven Seas Exports S.L Ltd | Agriculture & fishing | 2021 |
| Sevenera Limited | Financial services | 2025 |
| Sevenrain Ltd | Information & communication | 2020 |
| SEVER4N Ltd | Transport & logistics | 2025 |
| Sevhan Limited | Administrative & support | 2023 |
| SF Bamford Butchers Ltd | Wholesale & retail | 2024 |
| SF2 Rochdale Ltd | Wholesale & retail | 2025 |
| SFH PVT Ltd | Wholesale & retail | 2024 |
| SFP 1 Limited | Administrative & support | 2014 |
| SFP 2 Limited | Real estate | 2014 |
| SGC Windows Ltd | Administrative & support | 2022 |
| Sgpr Silviu Bygg Ltd | Construction | 2020 |
| SH Pharmacore Limited | Wholesale & retail | 2019 |
| SH Properties Rochdale Ltd | Extraterritorial | 2024 |
| Shabaz Bedding Ltd | Wholesale & retail | 2026 |
| Shabbir and Sons Ltd | Wholesale & retail | 2023 |
| Shada Holdings Ltd | Real estate | 2025 |
| Shadab Ltd | Wholesale & retail | 2022 |
| Shade.Hairloss Ltd | Wholesale & retail | 2024 |
| Shafi Property Investment Ltd | Financial services | 2024 |
| Shah Breezebuy Ltd | Wholesale & retail | 2024 |
| Shah Builders & Contractors Ltd | Construction | 2010 |
| Shah Consultancy Ltd | Education | 2017 |
| Shah Trendsnap UK Ltd | Wholesale & retail | 2024 |
| Shahed Alam Consulting Ltd | Professional & scientific | 2018 |
| Shaheen BI Limited | Health & social care | 2020 |
| Shahi Darbar Rochdale Ltd | Hospitality | 2025 |
| Shahid Optics Ltd | Other services | 2014 |
| Shahnai Limited | Information & communication | 2026 |
| Shahpur Ltd | Wholesale & retail | 2023 |
| Shahz Mart Ltd | Wholesale & retail | 2024 |
| Shahzad Mahmood Ltd | Transport & logistics | 2025 |
| Shaikh Healthcare Ltd | Health & social care | 2025 |
| Shakesrcd Ltd | Hospitality | 2026 |
| Shakscans Ltd | Public administration | 2021 |
| Shane Cooper Aesthetic Ltd | Health & social care | 2018 |
| Shane Cooper Ltd | Other services | 2017 |
| Sharif Medical (UK) Ltd | Health & social care | 2010 |
| Shark Clean Ltd | Administrative & support | 2025 |
| Sharkbyte Trading Limited | Wholesale & retail | 2013 |
| Sharktech Ltd | Wholesale & retail | 2025 |
| Sharp Cross + Mann LLP | | 2016 |
| Shaun Wellens Ltd | Professional & scientific | 2023 |
| Shaun's Chippy Ltd | Hospitality | 2024 |
| Shaw Hardcastle Ltd | Real estate | 2019 |
| Shaw Mitchell Limited | Professional & scientific | 2003 |
| Shaw Mitchell Partnership Limited | Professional & scientific | 2013 |
| Shaw Online Ltd | Wholesale & retail | 2025 |
| Shaz International Traders Limited | Wholesale & retail | 2025 |
| Shazfashions Ltd | Wholesale & retail | 2020 |
| Shazi Limited | Other services | 2018 |
| Shdd Ltd | Health & social care | 2012 |
| SHE Remains Brave CIC | Wholesale & retail | 2026 |
| Shealmore Limited | Wholesale & retail | 2015 |
| Sheikh Capital Estates Ltd | Real estate | 2025 |
| Sheikh Capital Holdings Ltd | Financial services | 2022 |
| Sheriff General Ltd | Transport & logistics | 2021 |
| Shetrades CIC | Wholesale & retail | 2026 |
| Shibli Properties Ltd | Real estate | 2025 |
| Shieldex Limited | Administrative & support | 2025 |
| Shila Shot Ltd | Wholesale & retail | 2025 |
| Shine Bright 787M Ltd | Other services | 2025 |
| Shinkiari Services Limited | Real estate | 2025 |
| Shipmart Ltd | Wholesale & retail | 2024 |
| Shish Cafe Limited | Hospitality | 2022 |
| Shish Cafe New Limited | Hospitality | 2020 |
| Shish Desserts Limited | Hospitality | 2023 |
| Shish Grill Limited | Hospitality | 2016 |