| SAL TM Consultancy Ltd | Professional & scientific | 2024 |
| Salam Aesthetics Ltd | Extraterritorial | 2024 |
| Salam Hire Ltd | Manufacturing | 2023 |
| Sale Waterpark Restaurant Limited | Hospitality | 2010 |
| Saleem Trading Limited | Wholesale & retail | 2023 |
| Saleem Wash Limited | Wholesale & retail | 2025 |
| Salehavenonline Ltd | Wholesale & retail | 2024 |
| Sales and Growth Strategies Limited | Other services | 2023 |
| Salina R Ltd | Professional & scientific | 2023 |
| Salt Bidco Limited | Financial services | 2020 |
| Salt Midco Limited | Financial services | 2020 |
| Salt Separation Services Limited | Manufacturing | 1990 |
| Salt Topco Limited | Financial services | 2020 |
| Saltbox Investments Ltd | Real estate | 2026 |
| SAM Binns Development Ltd | Construction | 2016 |
| SAM Chianca Design Ltd | Professional & scientific | 2023 |
| SAM Deals Ltd | Wholesale & retail | 2020 |
| SAM Performance Ltd | Wholesale & retail | 2019 |
| SAM Tech Films Ltd | Information & communication | 2023 |
| Sam.Commerce Ltd | Wholesale & retail | 2026 |
| Samba Dance and Fitness Ltd | Arts & recreation | 2015 |
| Same Difference Ltd | Wholesale & retail | 2026 |
| Sameday Pro Couriers Ltd | Transport & logistics | 2026 |
| Samina Management Consultants Ltd | Real estate | 2023 |
| Sammar Ltd | Wholesale & retail | 2012 |
| Samslite Ltd | Transport & logistics | 2021 |
| SAN Culture Ltd | Wholesale & retail | 2025 |
| SAN Rocco (Broadway) Limited | Hospitality | 2019 |
| Sandbrook & Kingston Property Services Ltd | Financial services | 2024 |
| Sandbrook Park Leisure Limited | Hospitality | 2009 |
| Sanderson's Floor & Roof Truss Company Limited | Manufacturing | 2009 |
| Sandos Civils Ltd | Extraterritorial | 2022 |
| Sandylane Store Ltd | Wholesale & retail | 2023 |
| Sandyvhairluxury Ltd | Administrative & support | 2026 |
| Sanelhca Limited | Health & social care | 2015 |
| Sanjom Health Care Limited | Health & social care | 2016 |
| Sanlya Ltd | Real estate | 2019 |
| Sansari Ltd | Professional & scientific | 2021 |
| Santacc Energy Co Ltd | Manufacturing | 2025 |
| Sanxi Newhey Limited | Hospitality | 2025 |
| Saporito Italiano Ltd | Hospitality | 2022 |
| Sapphire Fashions Limited | Wholesale & retail | 2022 |
| Sapphire Landmark Ltd | Real estate | 2025 |
| Sapphire Pictures Ltd | Information & communication | 2010 |
| SAQI97 Ltd | Wholesale & retail | 2025 |
| SAR Assets Ltd | Real estate | 2020 |
| SAR Consultants Limited | Information & communication | 2024 |
| Sara Refurbs Ltd | Real estate | 2026 |
| Saradi Construction Ltd | Construction | 2022 |
| Sarah R PP Care Ltd | Health & social care | 2017 |
| Saroba Enterprises Limited | Wholesale & retail | 2025 |
| Sartex Quilts & Textiles Limited | Manufacturing | 1992 |
| Sasha Ambridge Limited | Construction | 2024 |
| Sasi Architecture Ltd | Professional & scientific | 2020 |
| Sass Aesthetics Training Academy Ltd | Other services | 2022 |
| Saundocycle Ltd | Other services | 2021 |
| Saville Motors Limited | Wholesale & retail | 2023 |
| Sayem Solutions Ltd | Wholesale & retail | 2015 |
| Sazi Estates Ltd | Financial services | 2023 |
| SBG Rochdale Ltd | Arts & recreation | 2019 |
| SBM Corporate Real Estate Ltd | Real estate | 2009 |
| SBM Corporate Trading Limited | Administrative & support | 2017 |
| Scafell Hospitality Ltd | Hospitality | 2026 |
| Scalp & Skin Ltd | Professional & scientific | 2025 |
| Scandiasteel Limited | Administrative & support | 1992 |
| Scarsdale Solicitors Ltd | Professional & scientific | 2016 |
| Scbr Ltd | Professional & scientific | 2025 |
| Scented Moments Ltd | Wholesale & retail | 2024 |
| Scentsation Vending Ltd | Wholesale & retail | 2025 |
| SCG Enterprises Ltd | Administrative & support | 2025 |
| Schnauzer Electrics Ltd | Construction | 2017 |
| School of Tajweed Limited | Education | 2023 |
| Scip Limited | Health & social care | 2023 |
| Sciscript Medical & Scientific Communications Ltd | Professional & scientific | 2026 |
| Sclgm Properties Limited | Real estate | 2025 |
| SCP Cladding Ltd | Construction | 2023 |
| Scrap My Appliance Limited | Administrative & support | 2020 |
| Screem Building Maintenance Limited | Construction | 2010 |
| Screwloose Supplies Ltd | Construction | 2025 |
| Scrubscribe Ltd | Administrative & support | 2022 |
| SCS (Steel Cutting Services) Ltd | Water & waste | 2008 |
| Scylla Care Ltd | Health & social care | 2025 |
| SDP Engineering Limited | Construction | 2015 |
| SDS Security Posts Ltd | Construction | 2013 |
| Search Education Ltd | Education | 2025 |
| Search Talent Solutions Limited | Administrative & support | 2024 |
| Searz Holdings Ltd | Real estate | 2025 |
| Searz Investments Ltd | Real estate | 2020 |
| Searz Ltd. | Real estate | 2003 |
| Searz Maintenance Ltd | Construction | 2025 |
| Searz National Ltd | Real estate | 2022 |
| Season 7 Traders Ltd | Wholesale & retail | 2023 |
| Secure Workforce Group Limited | Administrative & support | 2022 |
| Secure Workforce Ltd | Administrative & support | 2012 |
| SECURE4UK Ltd | Administrative & support | 2025 |
| Securecheck Site Services Ltd | Administrative & support | 2009 |
| Security Edge Ltd | Administrative & support | 2020 |
| Security Empire Ltd | Extraterritorial | 2011 |
| Security Holdings & Recoveries Limited | Other services | 2017 |
| Seed & Co Properties Ltd | Real estate | 2025 |