| Salt & Batter Kitchen Ltd | Hospitality | 2025 |
| Saltydog Investor Limited | Information & communication | 2008 |
| Sandra Luehrmann Property Search Ltd | Other services | 2024 |
| Sangchun Ltd | Hospitality | 2023 |
| Saprogrow Ltd | Agriculture & fishing | 2022 |
| Sarah Doble Associates Limited | Professional & scientific | 2014 |
| Sark Partnership Ltd | Construction | 2017 |
| Saturday Developments Ltd | Construction | 2022 |
| Saturday Holdings Ltd | Real estate | 2025 |
| Sawa Investments Limited | Extraterritorial | 2024 |
| SB Decorative Finishes Ltd | Construction | 2018 |
| SC Property Management (Bath) Ltd | Real estate | 2022 |
| Scaffolding Solutions (South West) Ltd | Construction | 2018 |
| Scalpology Bath Limited | Other services | 2020 |
| Scarlet Tiger Press Ltd | Professional & scientific | 2023 |
| Sciencescope Limited | Professional & scientific | 2001 |
| Scorta Rossa Developments Limited | Construction | 2012 |
| Scott Leakey Ltd | Information & communication | 2014 |
| Scott Rowlands Plumbing & Heating Limited | Construction | 2022 |
| Seaside Property Investments Limited | Real estate | 2019 |
| Securitek Fire & Security Ltd | Construction | 2023 |
| SEE More Blinds Limited | Wholesale & retail | 2014 |
| Select Projects (Bristol) Limited | Construction | 2011 |
| Self Psychology Ltd | Health & social care | 2024 |
| Selway Electrical Engineering Ltd | Construction | 2025 |
| Senet Properties Ltd | Real estate | 2025 |
| Seven Hills Taxis Ltd | Transport & logistics | 2025 |
| Seviour Timber Frames Ltd | Construction | 2018 |
| Sezincote Property Holdings Ltd | Real estate | 2021 |
| Shadowcrest Holdings Ltd | Financial services | 2016 |
| Shafted Ltd | Professional & scientific | 2022 |
| Sharp Knives Sales & Training Limited | Wholesale & retail | 2015 |
| Sharp Logistics Ltd. | Transport & logistics | 2010 |
| Shaun Miles Ltd | Professional & scientific | 2009 |
| Shawfam Limited | Households | 2024 |
| Shearwater Communications Limited | Professional & scientific | 2017 |
| Shekinah Housing CIC | Hospitality | 2021 |
| Sheland Limited | Real estate | 2012 |
| Shepton & District Model Railway Club Ltd | Other services | 2026 |
| SHH Talent Ltd | Arts & recreation | 2023 |
| Shimada Property Limited | Real estate | 2002 |
| Shoot 4 the Moon Ltd | Professional & scientific | 2016 |
| Shop Neighbour Ltd | Wholesale & retail | 2023 |
| Showhawk DUO Limited | Arts & recreation | 2015 |
| Showworld Ltd | Arts & recreation | 2013 |
| Shroeders' Creative Limited | Arts & recreation | 2021 |
| Silaslutherhunt Ltd | Wholesale & retail | 2025 |
| Silverdale (Priddy) Management Company Limited | Households | 2022 |
| Silvitecture Limited | Construction | 1998 |
| Simcox Body Repairs Ltd | Wholesale & retail | 2016 |
| Simcox Property Investments LLP | | 2025 |
| Simple Recruitment (South West) Limited | Administrative & support | 2009 |
| SIP Property Maintenance Ltd | Construction | 2017 |
| SJ Hansford Ltd | Manufacturing | 2021 |
| SJ Whitespace Limited | Information & communication | 2009 |
| Sjds Distributions Ltd | Wholesale & retail | 2026 |
| Skala Estates Limited | Real estate | 2021 |
| Skemer's Community Boxing Club CIC | Arts & recreation | 2018 |
| Skjt Property Ltd | Real estate | 2020 |
| Smalls Bar Ltd | Hospitality | 2024 |
| Smart Home and Business Limited | Construction | 2015 |
| Smidge UK Limited | Construction | 2003 |
| Smoke Catering Ltd | Hospitality | 2015 |
| Snazzl Ltd | Wholesale & retail | 2025 |
| SO Fit Bath Ltd | Arts & recreation | 2019 |
| Software Radio Technology Limited | Manufacturing | 2013 |
| Solar Installations Green Nation Limited | Energy | 2011 |
| Solitaire Brides Ltd | Wholesale & retail | 2008 |
| Solomon Business Solutions Limited | Administrative & support | 2001 |
| Solstice Consulting Limited | Professional & scientific | 1995 |
| Somer Asset Management Limited | Professional & scientific | 2011 |
| Somer Court Management Company Limited | Households | 2001 |
| Somer Electrical Services Ltd. | Construction | 2024 |
| Somer Enterprises Ltd | Administrative & support | 2017 |
| Somer Motors Ltd | Wholesale & retail | 2014 |
| Somer Property Services Ltd | Construction | 2024 |
| Somer Valley Woodlands Ltd | Agriculture & fishing | 2016 |
| Somerset Capital Investments Limited | Real estate | 2016 |
| Somerset Contract Print Services Limited | Manufacturing | 2015 |
| Somerset Customs Limited | Manufacturing | 2025 |
| Somerset Flooring Supplies Limited | Wholesale & retail | 2025 |
| Somerset Scaffolding Limited | Construction | 1988 |
| Somerset Screed Limited | Construction | 2025 |
| Somerset Solders Ltd | Manufacturing | 2011 |
| Somerset Wealth Limited | Extraterritorial | 2017 |
| Somerset WM Limited | Financial services | 2017 |
| Somertech Ltd | Wholesale & retail | 2004 |
| Sounds of Frome Limited | Wholesale & retail | 2002 |
| South West Action for Learning and Living OUR Way Limited | Health & social care | 1995 |
| South West BIN Cleaning Company Limited | Administrative & support | 2011 |
| South West Community Business Hub CIC | Administrative & support | 2025 |
| South West Direct Cremations Limited | Other services | 2025 |
| South West Family Law (Bath) Limited | Professional & scientific | 2018 |
| South West Industrial Control Systems Ltd | Professional & scientific | 2019 |
| South West Upholstery School Ltd | Other services | 2018 |
| Southwest Masonry Limited | Construction | 2021 |
| Southwest Pools Ltd | Construction | 2022 |
| Sparkling Solutions (Commercial) Limited | Administrative & support | 2014 |
| Sparkling Solutions (SW) Limited | Administrative & support | 2014 |
| Specialist Tyre Consulting Limited | Professional & scientific | 2023 |