| SLT Training Company Ltd | Education | 2026 |
| Smalewell Properties Limited | Real estate | 2026 |
| Small Business Matters Ltd | Manufacturing | 2007 |
| Smart Barriers Ltd | Wholesale & retail | 2025 |
| Smart Power Products Limited | Manufacturing | 2016 |
| Smart Power Solutions LLP | | 2001 |
| Smartphone Projects Ltd | Information & communication | 2021 |
| SMG Electrical Ltd | Construction | 2025 |
| Snee Projects Limited | Professional & scientific | 2008 |
| SNI (Leeds) Limited | Administrative & support | 2011 |
| Snickers-Online Limited | Extraterritorial | 2008 |
| SNZ Holdings Limited | Real estate | 2018 |
| Solar Networks Limited | Professional & scientific | 2022 |
| Solar Pave Limited | Construction | 2024 |
| Solartek Energy Group Limited | Construction | 2025 |
| Solomon's Windows&Doors Ltd | Construction | 2024 |
| Solus Commercial Limited | Construction | 2024 |
| Sonduh Safety Solutions Ltd | Education | 2025 |
| Sonex Services Limited | Administrative & support | 2023 |
| Sophie Wilson Editorial Ltd | Other services | 2021 |
| South East Experts Builders Ltd | Construction | 2019 |
| Sova Healthcare (Leeds) Limited | Health & social care | 2021 |
| Sova Training Limited | Wholesale & retail | 2024 |
| SP Barker Soft Furnishings Ltd | Wholesale & retail | 2007 |
| Sparrow Eyecare Ltd | Wholesale & retail | 2011 |
| Spartan Greek Food Limited | Hospitality | 2025 |
| Special Sandook Ltd | Wholesale & retail | 2026 |
| Specialist Applied Security Limited | Professional & scientific | 2011 |
| Specialist Collection Services Limited | Extraterritorial | 2024 |
| Specialist Truck and Trailer Services Limited | Wholesale & retail | 2015 |
| Spectacular Scenes Limited | Other services | 2017 |
| Spikings Limited | Construction | 2014 |
| SPM Contracts (Leeds) Ltd | Construction | 2023 |
| Sport and Activity Professionals Ltd | Arts & recreation | 2010 |
| Sports Writing Limited | Information & communication | 2013 |
| Spring Valley Trading Limited | Manufacturing | 2019 |
| SPS Property Shop Ltd | Real estate | 2021 |
| Spud Spott Ltd | Hospitality | 2025 |
| SQS Pharmacists Limited | Health & social care | 2008 |
| SR Motor Group Ltd | Wholesale & retail | 2016 |
| SRH Fitness Ltd | Health & social care | 2026 |
| SRK Global Holdings Ltd | Administrative & support | 2026 |
| SSR Medical Services Ltd | Health & social care | 2018 |
| SSR Property Services Ltd | Real estate | 2024 |
| Ssuk Recruitment Group Ltd | Administrative & support | 2019 |
| ST Business Support Services Limited | Professional & scientific | 2020 |
| ST John's North Apartments SUB Ltd | Real estate | 2023 |
| ST Johns North Apartments Ltd | Construction | 2019 |
| ST Johns North Limited | Real estate | 2017 |
| Stableford Electrical Limited | Manufacturing | 2015 |
| Staff Store UK Ltd | Administrative & support | 2016 |
| Stanley Mills (Milnsbridge) Limited | Real estate | 2017 |
| Stanley Mills SUB Ltd | Real estate | 2022 |
| Stanningley Nails Limited | Other services | 2024 |
| Staparti Ltd | Wholesale & retail | 2023 |
| Star Barbers Pudsey Ltd | Other services | 2026 |
| Stefan Dawson Limited | Extraterritorial | 2025 |
| Stem Physiotherapy & Healthcare Ltd | Health & social care | 2021 |
| Stephens Education Services Ltd | Education | 2023 |
| Stepping Stones (East Morton) Management Company NO3 Ltd. | Households | 2001 |
| Steve Austwick MOT Centre Ltd | Wholesale & retail | 2023 |
| Stirling Development & Rental Ltd | Construction | 2026 |
| Stonehouse Blinds Limited | Wholesale & retail | 2024 |
| Stonehouse Inc Ltd | Construction | 2025 |
| Stormy Seas Fisheries Ltd | Hospitality | 2025 |
| Striding Investments Limited | Real estate | 2022 |
| Stuart James Builders Limited | Construction | 2021 |
| Studio Belly Timber Ltd | Professional & scientific | 2007 |
| Summitvisions Limited | Information & communication | 2016 |
| Sunfield Electrical Ltd | Construction | 2016 |
| Super Red Ltd | Hospitality | 2023 |
| Superstadiums Limited | Administrative & support | 2025 |
| Support Services Solutions Limited | Information & communication | 1998 |
| Sutcliffe Properties (Leeds) Limited | Households | 2021 |
| Sutcliffe's of Farsley Limited | Wholesale & retail | 2020 |
| Sweet Treat Creations Limited | Wholesale & retail | 2025 |
| Sweets for YOU (Leeds) Limited | Wholesale & retail | 2020 |
| Swept & Co Ltd | Administrative & support | 2026 |
| Swhorsfield Data Management Ltd | Information & communication | 2024 |
| Swinnow Community Centre CIC | Health & social care | 2024 |
| Switch Insure Ltd | Financial services | 2024 |
| Sylent Power Ltd | Energy | 2024 |
| Symbiosis Medicals Limited | Administrative & support | 2010 |
| Symbolista Limited | Professional & scientific | 2017 |
| Synergy Electrical Group Limited | Construction | 2024 |
| Syrinx ZA International Limited | Manufacturing | 2004 |
| Syrinx ZA Limited | Extraterritorial | 2008 |
| T & M Fire Solutions Ltd | Construction | 2018 |
| T & M Property Group Limited | Extraterritorial | 2023 |
| T Synergy Ltd | Wholesale & retail | 2018 |
| T&G Lofts Ltd | Construction | 2022 |
| T.& R.Williamson Limited | Manufacturing | 1894 |
| T.M.S. Design Consultants Limited | Professional & scientific | 1993 |
| TA and SJ Limited | Health & social care | 2025 |
| Tails and Trails Pet Services Ltd | Other services | 2022 |
| TAL Properties Limited | Real estate | 2022 |
| Talbot Hotel Limited | Construction | 2021 |
| Tammy Nails Pudsey Ltd | Other services | 2024 |
| Tang Lettings Ltd | Real estate | 2026 |
| Tankard Brewing Ltd | Wholesale & retail | 2024 |