| Ross Barnard Limited | Construction | 2015 |
| Rouse Electrical Contractors Limited | Construction | 2014 |
| Rouse Holdings (Leeds) Ltd | Financial services | 2022 |
| Rouse Property Developments Ltd | Real estate | 2021 |
| Rozina’S Creams Ltd | Wholesale & retail | 2025 |
| RSK Solutions (Leeds) Limited | Construction | 2018 |
| Rubyover Limited | Real estate | 1973 |
| Rubys Cafe Bar Ltd | Hospitality | 2025 |
| Ruche Consulting Limited | Professional & scientific | 2016 |
| Rupyal Restaurant &Takeaway Ltd | Hospitality | 2020 |
| RVC Management Company Limited | Professional & scientific | 2023 |
| Ryan Property Law LLP | | 2009 |
| Ryburn Leisure Inns Limited | Hospitality | 1987 |
| Ryken Solutions Ltd | Administrative & support | 2024 |
| S & G Granite Limited | Wholesale & retail | 2010 |
| S & J Holdings (Pudsey) Limited | Construction | 2005 |
| S & KO Logistics Limited | Transport & logistics | 2023 |
| S & O Roofing Ltd | Construction | 2026 |
| S E Cabry Limited | Households | 2015 |
| S I C Consultants Limited | Other services | 2012 |
| S Khosla Limited | Information & communication | 2018 |
| S.J.M. Motors Limited | Wholesale & retail | 2008 |
| S.One Nails Ltd | Other services | 2025 |
| Saanvi Consultancy Limited | Health & social care | 2014 |
| Saas Info Ltd | Information & communication | 2016 |
| SAB Pharma Ltd | Professional & scientific | 2019 |
| SAD Tech Ltd | Wholesale & retail | 2025 |
| Safety in Music CIC | Information & communication | 2020 |
| Sainivas (UK) Limited | Real estate | 2018 |
| Salford Global Retail Ltd | Wholesale & retail | 2025 |
| Salim Services Limited | Professional & scientific | 2018 |
| Same Difference Arts C.I.C. | Arts & recreation | 2018 |
| Samrad Limited | Administrative & support | 2021 |
| Sams Sarnies Leeds Limited | Hospitality | 2025 |
| Samson Athletics Ltd | Manufacturing | 2013 |
| Sam’S Sarnies Armley Ltd | Hospitality | 2026 |
| Sanbuild Ltd | Construction | 2015 |
| Sanitizem Ltd | Wholesale & retail | 2020 |
| Sano Physiotherapy 2017 Limited | Financial services | 2017 |
| Sano Physiotherapy Ltd | Health & social care | 2010 |
| Santaland Limited | Manufacturing | 2025 |
| Sarrum Events Ltd | Professional & scientific | 2023 |
| Satellite Consulting (UK) Limited | Professional & scientific | 1998 |
| Satinfort Limited | Information & communication | 1991 |
| Saturn Bidco Limited | Financial services | 2018 |
| Saturn Midco 1 Limited | Financial services | 2018 |
| Saturn Midco 2 Limited | Financial services | 2018 |
| Saturn Topco Limited | Financial services | 2018 |
| Savoy Lettings Ltd | Real estate | 2024 |
| SCAFFOLD365 Limited | Construction | 2021 |
| Scarlett Construction Services Ltd | Construction | 2023 |
| Scholebrook Estate Company Limited | Construction | 1958 |
| Scottline Group Ltd | Wholesale & retail | 2025 |
| Scrap Creative Reuse Arts Project Limited | Arts & recreation | 2009 |
| Sculpt and Refine Aesthetics Ltd | Other services | 2024 |
| SD Commercials Yorkshire Ltd | Wholesale & retail | 2025 |
| SD Theatre CIC | Arts & recreation | 2023 |
| SDC Plumbing and Heating (Leeds) Ltd | Construction | 2020 |
| SEE Commercial Grounds Maintenance Ltd | Administrative & support | 2025 |
| Seizing the Opportunity Limited | Manufacturing | 2023 |
| Sekhon Developments Ltd | Real estate | 2016 |
| Sekhon Group Limited | Real estate | 2020 |
| Sekhon Lettings Limited | Real estate | 2018 |
| Sekhon North Limited | Real estate | 2017 |
| Sekhon Real Estate Limited | Real estate | 2008 |
| Sekhon Utility Brokers Limited | Real estate | 2017 |
| SEN Parents Leeds C.I.C. | Health & social care | 2024 |
| Sendandpack Ltd | Other services | 2022 |
| Sense of Numbers Ltd | Professional & scientific | 2020 |
| Sensei AI Ltd | Information & communication | 2026 |
| Sensync Ltd | Wholesale & retail | 2025 |
| Sephid Estate Ltd | Real estate | 2026 |
| Sequoia Legal Finance Limited | Financial services | 2022 |
| Serenicity Limited | Professional & scientific | 2015 |
| Servatech Limited | Information & communication | 1996 |
| Servi GAS Ltd | Construction | 2023 |
| Seven Star Prop Ltd | Real estate | 2025 |
| Seventen M&E Ltd | Construction | 2025 |
| Sewer Rehab Services Ltd | Water & waste | 2025 |
| Shahmiro's Limited | Hospitality | 2023 |
| Shallom Care & Cleaning Services Ltd | Administrative & support | 2025 |
| Sharry-Khan Limited | Health & social care | 2023 |
| SHE WHO Dares Wins Global Limited | Wholesale & retail | 2020 |
| Sheila Brodie Funeral Services Limited | Other services | 2006 |
| Shezzaans Restaurant Leeds Ltd | Other services | 2013 |
| Shield Health & Social Care Limited | Administrative & support | 2019 |
| Shield Lettings LLP | | 2026 |
| Shree Guru Datta Properties Ltd | Real estate | 2021 |
| Sibs Property Ltd | Real estate | 2023 |
| SID Carpentry Limited | Construction | 2023 |
| Silver Bells Designs Limited | Other services | 2015 |
| Silver Dollar Micro Bar Ltd | Hospitality | 2018 |
| Silvers Bakehouse Ltd | Hospitality | 2026 |
| Simply Beautiful 2015 Limited | Other services | 2010 |
| Simply MSK Ltd | Health & social care | 2023 |
| Sister Solutions Ltd | Administrative & support | 2026 |
| Skelton Fibres Limited | Information & communication | 1973 |
| Skinyoulike London Ltd | Other services | 2025 |
| Skip IT Waste Ltd | Water & waste | 2025 |
| SL Leeds Ltd | Construction | 2026 |