| Energy Focus Developments Ltd | Construction | 2024 |
| Energy Focus Ltd | Construction | 2022 |
| Energy Grants 4 U Limited | Other services | 2019 |
| Energy Guide Limited | Energy | 2018 |
| Energy Industry Consultants Ltd | Administrative & support | 1970 |
| Energy Lancashire Ltd | Construction | 2021 |
| Energynestsolutions Ltd | Other services | 2025 |
| Engineered Polymers Limited | Manufacturing | 2020 |
| Engineered Ventilation Solutions Ltd | Construction | 2011 |
| Engineering OIL Consultancy Ltd | Professional & scientific | 2023 |
| Engines Northwest Ltd | Wholesale & retail | 2023 |
| Englo Infrastructure Limited | Construction | 2025 |
| Enhance Beauty Bar Limited | Real estate | 2017 |
| Enjoin Bespoke Limited | Construction | 2022 |
| Enjoinit Electrical Ltd | Construction | 2023 |
| Enlightened Homes Ltd | Real estate | 2020 |
| Enlightened Short Term Rentals Ltd | Real estate | 2022 |
| Enlightenment Network Limited | Information & communication | 2010 |
| Enloite Ltd | Wholesale & retail | 2025 |
| Enough Project Limited | Hospitality | 2023 |
| Enoura Group Limited | Health & social care | 2016 |
| Enrichment Partnership Ltd | Education | 2021 |
| ENS Estates Ltd | Households | 2025 |
| Ensee Ltd | Manufacturing | 2011 |
| Enso Martial Arts Academy Ltd | Education | 2018 |
| Enso Martial Arts North West CIC | Wholesale & retail | 2024 |
| Enstats Ltd | Professional & scientific | 2013 |
| Ensure Electrical Contractors Ltd. | Construction | 2023 |
| Ensure Properties NW Ltd | Real estate | 2024 |
| Ensys Engineering Consultants Ltd | Information & communication | 2015 |
| Entech (UK) Limited | Real estate | 1997 |
| Entech Engineering Limited | Manufacturing | 1996 |
| Entech Innovations Ltd | Professional & scientific | 2023 |
| Entelechy Academy Limited | Other services | 2020 |
| Enterprise Business Technologies Limited | Information & communication | 2003 |
| Enterprise Civic Buildings (Holdings) Limited | Professional & scientific | 2002 |
| Enterprise Civic Buildings Limited | Administrative & support | 2002 |
| Enterprise Court Limited | Real estate | 2016 |
| Enterprise Education Conwy Limited | Administrative & support | 2002 |
| Enterprise Education Holdings Conwy Limited | Professional & scientific | 2002 |
| Enterprise Healthcare Holdings Limited | Professional & scientific | 2003 |
| Enterprise Healthcare Limited | Administrative & support | 2003 |
| Enterprise Ventures (Coalfields Growth Founders) LLP | | 2008 |
| Enterprise Ventures (EV Growth Founders) LLP | | 2008 |
| Enterprise Ventures (EV Growth II Founders) LLP | | 2016 |
| Enterprise Ventures (EVG II North West Founders) LLP | | 2017 |
| Enterprise Ventures (General Partner Coalfields Growth) Limited | Financial services | 2007 |
| Enterprise Ventures (General Partner EV Growth II) Limited | Financial services | 2016 |
| Enterprise Ventures (General Partner EV Growth) Limited | Financial services | 2007 |
| Enterprise Ventures (General Partner EVG II North West) Limited | Financial services | 2017 |
| Enterprise Ventures (General Partner FY Seedcorn) Limited | Financial services | 2010 |
| Enterprise Ventures (General Partner Midlands POC) Limited | Financial services | 2017 |
| Enterprise Ventures (General Partner NE Venture) Limited | Financial services | 2016 |
| Enterprise Ventures (General Partner Npif Yhtv Equity) Limited | Financial services | 2016 |
| Enterprise Ventures (General Partner NW Venture) Limited | Financial services | 2010 |
| Enterprise Ventures (GP EVG II North West) LLP | | 2018 |
| Enterprise Ventures (GP Evgf II) LLP | | 2016 |
| Enterprise Ventures (Midlands POC Founders) LLP | | 2017 |
| Enterprise Ventures (NE Venture Founders) LLP | | 2016 |
| Enterprise Ventures (Npif Yhtv Equity Founders) LLP | | 2016 |
| Enterprise Ventures (NW Mezzanine Founders) LLP | | 2013 |
| Enterprise Ventures (NW Venture Founders) LLP | | 2010 |
| Enterprise Ventures (Risingstars II Founders) LLP | | 2006 |
| Enterprise Ventures Growth Fund | | 2009 |
| Enterprise Ventures Growth II LP | | 2016 |
| Enterprise Ventures SME Loans LP | | 2014 |
| Enterprises AP Ltd | Wholesale & retail | 2025 |
| Enterprizesoftwareservice Limited | Professional & scientific | 2024 |
| Enthuse Football Ltd | Administrative & support | 2026 |
| Entreplaneur Limited | Professional & scientific | 2012 |
| Entry to Europe Limited | Information & communication | 2021 |
| Ents Pro Ltd | Professional & scientific | 2024 |
| Entwistle Holding Limited | Administrative & support | 2018 |
| Entwood Accounting Limited | Professional & scientific | 2025 |
| Enviro Chef Limited | Financial services | 2023 |
| Enviro Clean Preston Ltd | Administrative & support | 2023 |
| Envirobed Ltd | Extraterritorial | 2022 |
| Enviroculture Limited | Extraterritorial | 1997 |
| Envirolec Development Services Limited | Energy | 2016 |
| Environmental Geoservices Limited | Professional & scientific | 2015 |
| Environmental Health on the Move Ltd | Professional & scientific | 2015 |
| Environmental Landfill Facilities Ltd | Water & waste | 2012 |
| Environmental Vehicle Solutions Ltd | Wholesale & retail | 2026 |
| Envirosystems (UK) Ltd | Manufacturing | 2001 |
| Envisel Ltd | Information & communication | 2022 |
| Envision CGI Ltd | Professional & scientific | 2022 |
| Envy Creations Ltd | Manufacturing | 2025 |
| EOC Medicals Limited | Wholesale & retail | 2023 |
| EOC Property Limited | Real estate | 2023 |
| EOS Dawn Holdings Limited | Financial services | 2025 |
| EP Construction and Plumbing Services Ltd | Other services | 2015 |
| EP Conveyancing Limited | Administrative & support | 2025 |
| EP GEN Ltd | Financial services | 2025 |
| EP Recruitment Ltd | Administrative & support | 2026 |
| EP Therapy Clinic Ltd | Health & social care | 2024 |
| Epel Limited | Real estate | 2022 |
| Epiphany Coaching Ltd | Other services | 2022 |
| Epocha Season Ltd | Wholesale & retail | 2024 |
| Epos Systems Direct Limited | Information & communication | 2007 |
| EPS Northwest Ltd | Manufacturing | 2024 |