| Shakespeare North Trust | Education | 2006 |
| Shampooch (UK) Limited | Professional & scientific | 2006 |
| Shaw Blinds & Interiors Ltd | Manufacturing | 2026 |
| Shaw's Floors Ltd | Wholesale & retail | 2010 |
| Shenuuka Limited | Real estate | 2025 |
| Signature Estate & Lettings Ltd | Construction | 2018 |
| Signing Angels Ltd | Education | 2016 |
| Silver Birch Asset Holding Limited | Administrative & support | 2020 |
| Silverside Developments Limited | Real estate | 2002 |
| Simply Skin Clinic and Trading Academy Ltd | Other services | 2024 |
| Sims Promotions Ltd | Professional & scientific | 2012 |
| Simwick Solutions Ltd | Professional & scientific | 2026 |
| Sinclair & Sons Constructions Ltd | Construction | 2020 |
| Sinclair Plant Hire Ltd | Administrative & support | 2021 |
| Sing Ping 2024 Ltd | Hospitality | 2024 |
| Sitesense Limited | Information & communication | 2025 |
| SJ Medical Consultant Ltd | Health & social care | 2010 |
| SJ Residential Properties Ltd | Real estate | 2026 |
| SJ Transport Services Limited | Extraterritorial | 2024 |
| SJS Computer Systems Limited | Information & communication | 1998 |
| Skelbo Path Limited | Professional & scientific | 2025 |
| Skew Bridge Alehouse Ltd | Hospitality | 2016 |
| SKI Runcorn Ltd | Arts & recreation | 2004 |
| Skie Property Limited | Real estate | 2023 |
| Skin Confidence Cheshire Ltd | Other services | 2025 |
| Skye Haulage Ltd | Transport & logistics | 2019 |
| SLB Contractors Limited | | 2010 |
| SLH Homes Limited | Health & social care | 2024 |
| Slotlease Property Management Limited | Households | 1990 |
| Smart Traffic Management Ltd | Construction | 2020 |
| SMC Construction Services Ltd | Construction | 2017 |
| Smith and LEA Property Ltd | Real estate | 2026 |
| Smith Bateson Holdings Limited | Wholesale & retail | 2008 |
| Smith's Car & Commercials Ltd | Wholesale & retail | 2011 |
| Smiths of Rainhill Limited | Real estate | 1969 |
| Smithy's Auto Repairs Ltd | Wholesale & retail | 2022 |
| SMJ Corporation Limited | Information & communication | 2017 |
| Snap Productions Limited | Wholesale & retail | 2009 |
| Social and Sober Ltd | Other services | 2026 |
| Solan Property Ltd | Real estate | 2023 |
| Solo Properties Ltd | Real estate | 2012 |
| Something Special (North West) Limited | Wholesale & retail | 2008 |
| Sons of Barber Ltd | Other services | 2026 |
| Sons of Blades Ltd | Other services | 2025 |
| Sophias Enchanted Events Limited | Other services | 2026 |
| Sophias Enchanted Garden Limited | Wholesale & retail | 2025 |
| Sotravel Ltd | Administrative & support | 2024 |
| Sovereign Company Management Ltd | Administrative & support | 2025 |
| Space and Freedom Limited | Professional & scientific | 2022 |
| SPC Prescot Ltd | Hospitality | 2026 |
| Spelman Estates Ltd | Real estate | 2025 |
| Spencer Heritage Services Ltd | Administrative & support | 2010 |
| Sphere Contract Solutions Ltd | Manufacturing | 2026 |
| Spice and Grains Ltd | Wholesale & retail | 2026 |
| Spion KOP Memorabilia Ltd | Wholesale & retail | 2021 |
| SPM Systems Ltd | Information & communication | 2024 |
| Sprayrendering Ltd | Construction | 2020 |
| Spruce Design Anti Ligature Services Ltd | Professional & scientific | 2013 |
| SPV NW Ltd | Professional & scientific | 2022 |
| SPV3 Ltd | Administrative & support | 2024 |
| Squarego Ltd | Information & communication | 2020 |
| SRA777 Consulting Limited | Professional & scientific | 2025 |
| SRN Consulting Solutions Ltd | Professional & scientific | 2024 |
| SRS Joinery & Building (North West) Ltd | Construction | 2026 |
| SSA Independent Social Care Limited | Health & social care | 2020 |
| Stanley Group Trading | Financial services | 2026 |
| Stanley Group Ventures Limited | Financial services | 2026 |
| Star Dust Electrical Limited | Wholesale & retail | 2023 |
| Star Spirit Leisure Limited | Arts & recreation | 2021 |
| Station Coffee House Limited | Hospitality | 2015 |
| Stationery Office Supply Limited | Wholesale & retail | 2012 |
| Statutory Testing & Inspection Limited | Professional & scientific | 2012 |
| Statutory Testing Inspection Limited | Information & communication | 2014 |
| Stellarjw Ltd | Hospitality | 2025 |
| Stelray Limited | Information & communication | 2024 |
| Stephen FOX Garage Limited | Wholesale & retail | 2004 |
| Stephen Lyon Limited | Wholesale & retail | 2007 |
| Stephenson Multi Academy Trust | Education | 2017 |
| Steve Cannon Ltd | Transport & logistics | 2022 |
| Stewart Holdings Management Limited | Mining & quarrying | 2006 |
| Stillfiik Mechanical Ltd | Construction | 2025 |
| Stone Sill Solutions Ltd | Construction | 2026 |
| Stonecross Consultancy Ltd | Information & communication | 2005 |
| Streamline Plumbing and Hvac Ltd | Construction | 2025 |
| Strive Property Group Ltd | Real estate | 2025 |
| Structure & Build Assets Ltd | Real estate | 2025 |
| Structurewise Ltd | Professional & scientific | 2019 |
| STS Realisations Limited | Other services | 2015 |
| Sttw Consultancy Limited | Administrative & support | 2024 |
| Stuart Davis Consulting Ltd | Professional & scientific | 2020 |
| Studio Argent,Limited | Professional & scientific | 1962 |
| Suga and Spice Ltd | Other services | 2019 |
| Sultana Sussex Ltd | Professional & scientific | 2023 |
| Sunny Construction NSS Ltd | Construction | 2020 |
| Sunny Speech and Language Therapy Ltd | Health & social care | 2025 |
| Sunray Creative Ltd | Arts & recreation | 2020 |
| Sunshine Car Parts Ltd | Wholesale & retail | 2023 |
| Sunshine Management Support Ltd | Administrative & support | 2026 |
| Supa-Kleen Services Limited | Manufacturing | 1995 |
| Sure Mechanical Services Limited | Professional & scientific | 2018 |