| Raja & Anamika Medical Consultancy Ltd | Health & social care | 2024 |
| Rajee Retail Ltd | Wholesale & retail | 2020 |
| Ramsay Residential Ltd | Extraterritorial | 2025 |
| Ranigrign Ltd | Administrative & support | 2025 |
| RD News Agent Ltd | Wholesale & retail | 2016 |
| RDT Commercials Ltd | Wholesale & retail | 2020 |
| Reach Rainhill C.I.C. | Health & social care | 2025 |
| Rebecca DOT Consultancy Limited | Financial services | 2015 |
| Recycling Equipment Engineering Limited | Manufacturing | 2016 |
| Red Architectural Engineers Ltd | Construction | 2024 |
| Red Carpet Consultancy Ltd | Professional & scientific | 2024 |
| Red Centre Global Ltd | Administrative & support | 2018 |
| Red Coat Apparel Limited | Wholesale & retail | 2023 |
| Red Station Finance Limited | Financial services | 2024 |
| Redason Limited | Health & social care | 2009 |
| Redwall LA Dita Limited | Arts & recreation | 2001 |
| Reliable Vehicle Sales Ltd | Wholesale & retail | 2015 |
| Renshall Tyre Solutions Ltd | Wholesale & retail | 2020 |
| Renwick Medical Limited | Health & social care | 2018 |
| RH Joinery&Tiling Ltd | Construction | 2025 |
| Rhema Supplies Limited | Wholesale & retail | 2024 |
| Richard Power Homes Ltd | Real estate | 2016 |
| Richmond Housing Developments Ltd | Hospitality | 2026 |
| Ridgesteel Fabrications Limited | Manufacturing | 2014 |
| Riley Telecommunications Ltd | Construction | 2022 |
| Ripple Leaf Limited | Health & social care | 2026 |
| Rising Star ( Liverpool ) Ltd | Hospitality | 2014 |
| Ritherup Management Company Limited | Households | 2024 |
| Rivformwork Ltd | Construction | 2024 |
| Rkcomms Limited | Information & communication | 2013 |
| Roadrunners (2019) Limited | Transport & logistics | 2019 |
| Robert Lindsay Energy Ltd | Professional & scientific | 2022 |
| Rock House Rainhill Management Limited | Real estate | 2020 |
| Romeck Ltd | Real estate | 2025 |
| Ronnan Corporation (Energy) Ltd | Energy | 2020 |
| Ronnie Hayes Limited | Hospitality | 2012 |
| Root & CAP Ltd | Professional & scientific | 2026 |
| RPS Switchgear Ltd | Manufacturing | 2013 |
| Rs&T Holdings Ltd | Education | 2025 |
| RSB Logicakes Limited | Transport & logistics | 2017 |
| Ruby FOX Networks Ltd. | Information & communication | 2017 |
| Runswithscissors Ltd | Professional & scientific | 2018 |
| Runway Impex Ltd | Transport & logistics | 2021 |
| Rushvfx Ltd | Arts & recreation | 2023 |
| Russell Roofing North West Limited | Construction | 2017 |
| Rutland International Limited | Wholesale & retail | 1998 |
| Ryan Whiston Contracting Ltd | Professional & scientific | 2025 |
| Rösler UK Ltd | Manufacturing | 2020 |
| S & a Maintenance Services Ltd | Construction | 2023 |
| S & S Anaesthetics Limited | Health & social care | 2011 |
| S Daley & SON Ltd | Construction | 2012 |
| S.C.A Hughes Properties Ltd | Real estate | 2018 |
| S.T.B. Aslam Ltd | Health & social care | 2021 |
| S2 Stark Limited | Administrative & support | 2011 |
| SA Damp Solutions Ltd | Construction | 2025 |
| SA Roofing Limited | Construction | 2024 |
| Sabra Group Ltd | Financial services | 2025 |
| Sad-Jaf-Far Limited | Administrative & support | 2019 |
| Saeed Yusuf Ltd | Health & social care | 2019 |
| Safari Bidco Limited | Professional & scientific | 2022 |
| Safe Seal Conservatories Ltd | Construction | 2026 |
| Saffron Spice Rainhill Limited | Hospitality | 2026 |
| SAL Ceilings and Partitions Limited | Construction | 2018 |
| SAL Construction Group Limited | Financial services | 2021 |
| SAL Construction Limited | Construction | 2013 |
| SAL Developments Ltd | Construction | 2017 |
| SAL Firestopping Ltd | Construction | 2016 |
| SAL Housing Limited | Real estate | 2020 |
| SAL Land & Property Limited | Construction | 2021 |
| SAL Plant Hire Limited | Administrative & support | 2021 |
| Salex Developments Ltd | Construction | 2016 |
| Salkeld Investments Limited | Real estate | 2020 |
| Salutem Training Ltd | Education | 2023 |
| SAM Engineering Ltd | Professional & scientific | 2023 |
| Sampaio Consulting Ltd | Professional & scientific | 2025 |
| Santos Pizzeria Limited | Hospitality | 2022 |
| Sapphire Valeting Ltd | Wholesale & retail | 2018 |
| Sapphire Vehicle Logistics Ltd | Transport & logistics | 2017 |
| Sarkauskas Limited | Wholesale & retail | 2018 |
| Satchel&Co Ltd | Manufacturing | 2023 |
| Sathra Ltd | Information & communication | 2025 |
| Scheme Trader Limited | Information & communication | 2018 |
| SCI Assessments Ltd | Health & social care | 2009 |
| Scotts Deliveries Limited | Transport & logistics | 2025 |
| Scratch Snacks Limited | Manufacturing | 2025 |
| Screenking Printing & Embroidery Ltd | Manufacturing | 2008 |
| Sealed With a Kiss Ltd | Wholesale & retail | 2024 |
| Sealfit Limited | Construction | 2019 |
| Seaside Hoteliers Ltd | Hospitality | 2022 |
| Securemac Integrated Limited | Administrative & support | 2018 |
| SEE YOU SEE ME CIC | Arts & recreation | 2023 |
| SEI Property Holdings Ltd | Real estate | 2022 |
| SEI Rocks Ltd | Administrative & support | 2024 |
| Sellookgroup Ltd | Construction | 2023 |
| Sensora Limited | Manufacturing | 2014 |
| Services by RS Limited | Information & communication | 2021 |
| Sevenoaks Cheshire Ltd | Real estate | 2026 |
| Seyhan Fast Food Limited | Hospitality | 2025 |
| Shads Property Ltd | Real estate | 2015 |
| Shakespeare North Playhouse Production Ltd | Arts & recreation | 2022 |