| Rwcreations Limited | Wholesale & retail | 2025 |
| Rwhv Ltd | Education | 2025 |
| RWL Portsmouth CIC | Health & social care | 2021 |
| Ryan Penfold Limited | Information & communication | 2017 |
| Ryan's Interior Systems Limited | Construction | 2018 |
| Ryan's World Ltd | Manufacturing | 2025 |
| Rybczynski Ltd | Professional & scientific | 2018 |
| Rydal Hall Management Services Limited | Administrative & support | 2002 |
| Ryde Demolition & Reclamation Limited | Construction | 2022 |
| Ryde Demolition Company Limited | Construction | 1985 |
| S & C Motors Ltd | Manufacturing | 2019 |
| S & C Recycling Limited | Administrative & support | 2024 |
| S & F Johns Electrical Limited | Other services | 2014 |
| S & N Carpentry Limited | Construction | 2013 |
| S & O Property Rentals Limited | Real estate | 2023 |
| S & O Property Services South Ltd | Construction | 2014 |
| S & R Property Sourcing Ltd | Real estate | 2020 |
| S Alam Financial Services Ltd | Financial services | 2020 |
| S and L Roofing Limited | Construction | 2025 |
| S B West Limited | Professional & scientific | 2014 |
| S Bryant Carpentry Limited | Construction | 2018 |
| S D J Hydraulics Limited | Administrative & support | 2007 |
| S D J Property Holdings Limited | Real estate | 2022 |
| S Donaldson Investments Limited | Financial services | 2025 |
| S Gibbs Electrical Services Ltd | Construction | 2025 |
| S Hardy Holdings Limited | Financial services | 2025 |
| S J Detailing Ltd. | Professional & scientific | 2022 |
| S J Hall Holdings Limited | Real estate | 2017 |
| S N REG Allied Health Limited | Administrative & support | 2017 |
| S P Painting & Decorating (Southern) Ltd | Construction | 2025 |
| S Peattie & SON Limited | Construction | 2023 |
| S R O Business Services Limited | Administrative & support | 2006 |
| S Thomas-Taylor Limited | Construction | 2005 |
| S&C Motors (Southampton) Limited | Wholesale & retail | 2024 |
| S&D Games Ltd | Arts & recreation | 2026 |
| S&H Hand Car Wash Ltd | Administrative & support | 2026 |
| S&H Pipework Ltd | Construction | 2024 |
| S&J Handyman Services Ltd | Construction | 2026 |
| S&R Carpentry Ltd | Manufacturing | 2023 |
| S&S Roofing & Building Limited | Construction | 2022 |
| S&T Wingham Estates Ltd | Real estate | 2025 |
| S. a. Claffey Limited | Construction | 2008 |
| S. Roberts Upholsterers Limited | Manufacturing | 2002 |
| S.Burns Company Ltd | Financial services | 2025 |
| S.C.P. Marine Innovation Limited | Professional & scientific | 2013 |
| S.D.J. Fluid Systems Limited | Administrative & support | 2000 |
| S.J.S. Brickwork Limited | Construction | 2015 |
| S.K. Interiors Limited | Construction | 1999 |
| S.K.Claffey Developments Ltd | Real estate | 2025 |
| S.M.K. Holdings Limited | Professional & scientific | 2006 |
| S.T.B Property Services Limited | Real estate | 2025 |
| S.V.M. Services Limited | Transport & logistics | 2006 |
| SA Mughal Limited | Health & social care | 2022 |
| SA Plant Operations Limited | Construction | 2014 |
| SAA (Southern) Ltd | Real estate | 2026 |
| Saamba Ltd | Wholesale & retail | 2025 |
| Saas Homes Ltd | Construction | 2024 |
| Sabapathi Trading Ltd | Construction | 2019 |
| Saber Powersports Limited | Transport & logistics | 2001 |
| Sable W Holdings Ltd | Professional & scientific | 2023 |
| Sabre Assessing Ltd | Financial services | 2021 |
| Sabre Interiors (UK) Ltd | Construction | 2017 |
| Sacred Healing Ltd | Health & social care | 2024 |
| Sadek Investments LLP | | 2023 |
| Sadler Mulholland Limited | Hospitality | 1987 |
| Saerima Ltd | Wholesale & retail | 2023 |
| Safe Marine Ltd | Professional & scientific | 2016 |
| Safe Systems Consulting Limited | Health & social care | 2016 |
| Safe T Marine Ltd | Construction | 2008 |
| Saferfood.Co.Uk Ltd | Administrative & support | 2008 |
| Saff Care Ltd | Health & social care | 2024 |
| Safisha Cleaning Services Ltd | Administrative & support | 2024 |
| Safsons Ltd | Hospitality | 2020 |
| Sagbert Ltd | Real estate | 2018 |
| SAI Burger Limited | Hospitality | 2025 |
| SAI Tasty Food Ltd | Hospitality | 2025 |
| Sailblue Ltd | Manufacturing | 2017 |
| Saintso Limited | Public administration | 2023 |
| Sairam Food and Wine Ltd | Wholesale & retail | 2017 |
| Sairam Property Services Ltd | Real estate | 2025 |
| Saje Upvc Limited | Construction | 1989 |
| Sajh Ltd | Construction | 2026 |
| Sajid Consultancy Services Ltd | Information & communication | 2008 |
| Salam Fratton Food Center Ltd | Wholesale & retail | 2021 |
| Sale & SON Limited | Agriculture & fishing | 2003 |
| Salisbury Properties Limited | Hospitality | 2005 |
| Salon Lookbook Ltd | Information & communication | 2019 |
| Salsa Events Limited | Arts & recreation | 2025 |
| Salsa Solent Limited | Arts & recreation | 2024 |
| Salt and Blossom Limited | Manufacturing | 2024 |
| Salt Living Limited | Hospitality | 2014 |
| Saltwater Property Ltd | Real estate | 2021 |
| Salve Investments (13 School) Ltd | Real estate | 2019 |
| Salve Investments (Abbey HEY) Ltd | Real estate | 2017 |
| Salve Investments (Ashton Old) Ltd | Real estate | 2019 |
| Salve Investments (Birch) Ltd | Real estate | 2017 |
| Salve Investments (Bury) Ltd | Real estate | 2017 |
| Salve Investments (Clough Fold) Ltd | Real estate | 2017 |
| Salve Investments (Croft Gates) Ltd | Real estate | 2017 |
| Salve Investments (FIR) Ltd | Real estate | 2017 |