| Simply Easi Recycling Ltd | Extraterritorial | 2009 |
| Simply Elegant Ltd | Wholesale & retail | 2024 |
| Simpson Kelly Associates Ltd. | Financial services | 2011 |
| Sing-O Garden Services Ltd | Administrative & support | 2023 |
| SIT Down Limited | Financial services | 2019 |
| SIXTY82-UK Limited | Wholesale & retail | 2025 |
| SJ Thrower Ltd | Professional & scientific | 2020 |
| SJM Properties (West Yorkshire) Ltd | Real estate | 2021 |
| SK & SP Painting & Decorating LLP | | 2024 |
| SKH Property Services Limited | Real estate | 2014 |
| SKH Services Limited | Real estate | 2002 |
| Skinaid Ltd | Wholesale & retail | 2020 |
| Skinlab Medical Aesthetics Ltd | Health & social care | 2026 |
| SKL Business Improvement Solutions Ltd | Administrative & support | 2016 |
| Skouto Limited | Information & communication | 2025 |
| Sky Emerald Ventures Ltd | Real estate | 2019 |
| Sky Nails PT Ltd | Other services | 2026 |
| Skyline Events Group Ltd | Arts & recreation | 2024 |
| Slatter Training Ltd | Administrative & support | 2009 |
| SLF Management Consultancy Ltd | Professional & scientific | 2019 |
| Slide Motorsport Limited | Wholesale & retail | 2015 |
| SM Takeaway Ltd | Hospitality | 2024 |
| Smart Advice Consulting Limited | Administrative & support | 2022 |
| Smart Advice Holdings Limited | Administrative & support | 2025 |
| Smart FAB Welding & Fabrications Limited | Manufacturing | 2021 |
| Smart K9 Limited | Professional & scientific | 2020 |
| Smart Kutz Ltd | Other services | 2021 |
| Smart Lease Properties Ltd | Real estate | 2024 |
| Smartprint (Yorkshire) Limited | Manufacturing | 2002 |
| Smashin Pubs Ltd | Hospitality | 2026 |
| Smeaton 1967 Limited | Extraterritorial | 2013 |
| Smeaton Developments Limited | Construction | 2010 |
| Smithfield Murray Holdings Limited | Professional & scientific | 2003 |
| Smithfield Murray Limited | Manufacturing | 1987 |
| Smithfield Poultry Limited | Manufacturing | 2009 |
| SMK Administration Ltd | Real estate | 2025 |
| Snaith Hall Limited | Health & social care | 2002 |
| Snowden Seamless Floors Limited | Construction | 2009 |
| Snowden Seamless Floors Trustees Limited | Professional & scientific | 2024 |
| Snydale Plant Limited | Mining & quarrying | 2017 |
| SOFTWARE4HR Limited | Information & communication | 2006 |
| Solar Xpress Installations Ltd | Construction | 2022 |
| Solo Optical Glazing Services Limited | Administrative & support | 2024 |
| Sonder Barbershop Limited | Other services | 2026 |
| Sonnylawretailer Ltd | Wholesale & retail | 2025 |
| Soul Cafe Connect Ltd | Extraterritorial | 2021 |
| Sounds Incorporated Ltd | Wholesale & retail | 2010 |
| South Elmsall Community Facilities Ltd | Administrative & support | 2012 |
| South Elmsall Fast Food Company Ltd | Hospitality | 2024 |
| South Elmsall Florist Limited | Wholesale & retail | 2022 |
| South Elmsall Pets Ltd | Wholesale & retail | 2024 |
| South Elmsall Stores Ltd | Wholesale & retail | 2018 |
| South Elmsall Travel Ltd | Administrative & support | 2011 |
| South Kirkby Service Station Ltd | Wholesale & retail | 2023 |
| South Lawns Spa Limited | Arts & recreation | 2021 |
| South Yorkshire Marble Company Limited | Manufacturing | 1988 |
| Southmoor Property Development & Investment Limited | Extraterritorial | 2008 |
| Southway School Limited | Education | 2013 |
| Space Student & Pro Lets Ltd | Households | 2025 |
| Sparham Harnell Limited | Professional & scientific | 2017 |
| Sparrow Maintenance Ltd | Construction | 2024 |
| Spartacus Abseiling Limited | Other services | 2025 |
| Speakman Catering Ltd | Hospitality | 2023 |
| Specialist Cable Contractors Limited | Construction | 2006 |
| Specialist Tooling Technologies Ltd | Manufacturing | 2003 |
| Spectral Ltd | Information & communication | 2012 |
| Spice Garden Pontefract Ltd | Hospitality | 2025 |
| Spice Revive CIC | Education | 2024 |
| Spirit Fitness Ltd | Arts & recreation | 2023 |
| Spirit Martial Arts LLP | | 2022 |
| Splash Bathrooms Yorkshire Ltd | Construction | 2020 |
| Splinters Leeds Ltd | Wholesale & retail | 2022 |
| Sports Scouting Network Limited | Arts & recreation | 2017 |
| Sports Turf Solutions Ltd | Professional & scientific | 2015 |
| Springboard Adult Services Limited | Health & social care | 2008 |
| Springfields Residential Home Limited | Health & social care | 2011 |
| SPY Lifting Services Limited | Manufacturing | 2018 |
| Square Metre Contract Flooring Ltd | Construction | 2024 |
| Squaring UP Training Ltd | Education | 2022 |
| Squirrel Cottage Ltd | Hospitality | 2023 |
| SR Electrical Sesku Ltd | Construction | 2022 |
| SR Industries Yorkshire Ltd | Professional & scientific | 2024 |
| SR Washmaster Limited | Administrative & support | 2025 |
| SR Wilson Hospitality Ltd | Hospitality | 2024 |
| SR Wilson Properties Ltd | Real estate | 2021 |
| SRF Brickwork Ltd | Construction | 2019 |
| Srii BN Tradings Ltd | Wholesale & retail | 2023 |
| SRJ Training Limited | Health & social care | 2025 |
| SRS Electrical & Security Services Limited | Construction | 2022 |
| SSJ Accounting Limited | Professional & scientific | 2023 |
| Sssr JBN Ltd | Wholesale & retail | 2026 |
| Sssribtrading Ltd | Wholesale & retail | 2020 |
| ST Heatlab Ltd | Wholesale & retail | 2023 |
| ST Luke's Church | Education | 2006 |
| ST Shop Limited | Wholesale & retail | 2026 |
| ST. Mary's Chequerfield Community Project Limited | Education | 2003 |
| Stage Technologies (Asia-Pacific) Ltd | Professional & scientific | 2006 |
| Stanciu Logistics Limited | Transport & logistics | 2017 |
| Standard Contractors Limited | Construction | 2010 |
| Starks Builders Ltd | Construction | 2022 |