| S Gordon Building & Restoration Ltd | Construction | 2019 |
| S James & SON Properties Limited | Real estate | 2025 |
| S Parken Electrical Ltd | Construction | 2025 |
| S&S Attractions Limited | Arts & recreation | 2024 |
| S&S Tours Ltd | Administrative & support | 2025 |
| S&T Haulage Ltd | Transport & logistics | 2021 |
| S.R Freelance Contractors Ltd | Transport & logistics | 2025 |
| S2B Property Ltd | Construction | 2025 |
| SA Arogya Foods Limited | Hospitality | 2023 |
| SAA Assets Ltd | Transport & logistics | 2024 |
| Safe Project Planning Ltd | Professional & scientific | 2015 |
| Safe Site Hire & Sales Ltd | Construction | 2012 |
| Safefloor UK Limited | Administrative & support | 2017 |
| Safetying Ltd | Professional & scientific | 2023 |
| Sage Repair Network Limited | Professional & scientific | 2012 |
| Sage Sister Ltd | Wholesale & retail | 2026 |
| Saint Nana Healthcare Ltd | Health & social care | 2020 |
| Sakan Corporate Limited | Professional & scientific | 2014 |
| Sakan Limited | Professional & scientific | 2014 |
| Sales Direct Online Limited | Wholesale & retail | 2010 |
| Salsify Creative Ltd | Professional & scientific | 2011 |
| Salt Properties Limited | Real estate | 2004 |
| SAM Bishop Limited | Transport & logistics | 2015 |
| SAM Greenwood Home Improvements Limited | Construction | 2023 |
| SAM Parker Joinery Ltd | Construction | 2024 |
| Samuel Whitton Photography Limited | Professional & scientific | 2021 |
| Samurai Martial Arts Supplies Ltd | Wholesale & retail | 2021 |
| Sanger Financial Services Ltd | Financial services | 2018 |
| Sankui Limited | Administrative & support | 2017 |
| SAP Civil Management Ltd | Construction | 2014 |
| SAR Group of Companies Ltd | Wholesale & retail | 2025 |
| SAS (Pontefract) Holdings Ltd | Financial services | 2024 |
| Saske Ltd | Administrative & support | 2025 |
| Savage Haulage Limited | Transport & logistics | 2003 |
| Savage Martial Arts Pontefract Ltd. | Education | 2025 |
| Savant Cleaning Services Ltd | Administrative & support | 2026 |
| Savant Software Limited | Information & communication | 2026 |
| SB GAS Plumbing & Heating Limited | Professional & scientific | 2018 |
| SB Solutions (Yorkshire) Ltd | Education | 2025 |
| Scalewareuk Ltd | Professional & scientific | 2023 |
| Scawsby MOT and Car Care Centre Limited | Wholesale & retail | 2006 |
| SCB Housing Limited | Real estate | 2025 |
| Scbmaintenance Ltd | Construction | 2022 |
| Schosween 28 Limited | Manufacturing | 2014 |
| SCL Recruitment Ltd | Administrative & support | 2025 |
| Scotiahouse Leisure Limited | Hospitality | 1993 |
| Scotson Property Ltd | Real estate | 2026 |
| Scott M Wilson Ltd | Health & social care | 2021 |
| SDB European Ltd | Transport & logistics | 2021 |
| SDM Auto Care Limited | Manufacturing | 2018 |
| SDS Plastering Ltd | Construction | 2024 |
| Seasons Landscaping Limited | Administrative & support | 2023 |
| Seba Logistics Ltd | Transport & logistics | 2018 |
| Second Turn Ltd | Manufacturing | 2025 |
| Secure Access Ltd | Administrative & support | 2019 |
| Secure Design Technology Ltd | Administrative & support | 2011 |
| Secure Global Ltd | Wholesale & retail | 2005 |
| Secure Technical Services Limited | Administrative & support | 2025 |
| Sedd Properties Limited | Real estate | 2021 |
| Sedol B Limited | Wholesale & retail | 2017 |
| Sedol Property Ltd | Real estate | 2021 |
| Sellright Advisory Limited | Administrative & support | 2026 |
| Sendzest Ltd | Professional & scientific | 2025 |
| Sengoku Martial Arts Leeds Ltd | Education | 2025 |
| Serene for Kids Limited | Information & communication | 2024 |
| Serene Rendition Ltd | Real estate | 2022 |
| Serenity Motion Ltd | Arts & recreation | 2025 |
| Sesku Scaffolding Limited | Construction | 2016 |
| SFK Paper Ltd | Wholesale & retail | 2021 |
| SGC Mobile Motorhaus Ltd | Wholesale & retail | 2025 |
| SGJ Property Rentals Ltd | Real estate | 2024 |
| Shadow INK Tattoo Studio Ltd | Other services | 2020 |
| Shahan Car Wash Limited | Administrative & support | 2022 |
| Shandelm Ltd | Real estate | 2021 |
| Sharp Focus Video Limited | Wholesale & retail | 2025 |
| Shaw Sight Consultancy Limited | Wholesale & retail | 2012 |
| Shaw Sight Property Limited | Real estate | 2018 |
| Shaw’S Safety Solutions Ltd | Professional & scientific | 2021 |
| Sheard European Management Consultants Limited | Professional & scientific | 2003 |
| Sheath Fault Specialists Limited | Administrative & support | 2016 |
| Shed Audio Ltd | Manufacturing | 2025 |
| Sheer Blooms Ltd | Arts & recreation | 2021 |
| Sheffield Woodturning Club | Other services | 2022 |
| Shelly the Scalp Studio Ltd | Other services | 2026 |
| Shenroe Limited | Hospitality | 2022 |
| Sheriff Plumbing & Heating Ltd | Construction | 2017 |
| Shine Performance Services Ltd | Other services | 2026 |
| Shocal Doncaster Ltd | Wholesale & retail | 2024 |
| Shop in Shop Ltd | Wholesale & retail | 2019 |
| SHREE7 Ltd | Wholesale & retail | 2026 |
| Shuhag Indian Restaurant Ltd | Hospitality | 2013 |
| Shurma WF7 Ltd | Hospitality | 2024 |
| Siddiqui & Sons Limited | Wholesale & retail | 2011 |
| Sigma Windows (Yorkshire) Limited | Wholesale & retail | 2000 |
| Sila Services Limited | Transport & logistics | 2018 |
| Silver Charms UK Ltd | Wholesale & retail | 2025 |
| Silver Scissors Pontefract Ltd | Other services | 2021 |
| Silverleigh Property Solutions Limited | Hospitality | 2022 |
| SIM Fit-Out Ltd | Construction | 2021 |
| Simple House Limited | Transport & logistics | 2015 |