| Sail and Shade Systems Ltd | Wholesale & retail | 2018 |
| Sail Tribe Clothing Ltd | Wholesale & retail | 2023 |
| Sailing Tectona CIC | Manufacturing | 2018 |
| Sailor One Limited | Real estate | 2025 |
| Sailport PLC | Arts & recreation | 1979 |
| Saina Accessories Ltd | Manufacturing | 2026 |
| Sairer Ltd | Wholesale & retail | 2021 |
| Saisivas Plymouth Ltd | Wholesale & retail | 2026 |
| SAJ Window Cleaners Limited | Administrative & support | 2006 |
| Salar Surgical Ltd | Manufacturing | 2014 |
| Salcombe Chandlers Limited | Hospitality | 1964 |
| Salcombe Hot Tubs & Pools Ltd | Administrative & support | 2025 |
| Salcombe Launch Company Ltd | Administrative & support | 2026 |
| Salcombe Rigging Services Ltd | Extraterritorial | 2023 |
| Salcombe Smokers Limited | Extraterritorial | 2015 |
| Salcombe Smokies Limited | Extraterritorial | 2015 |
| Salcon Limited | Information & communication | 1997 |
| Saleca Limited | Wholesale & retail | 2024 |
| Sales Repairs Ltd | Wholesale & retail | 2023 |
| Salisbury Properties (Plymouth) Limited | Households | 1982 |
| Sally Legg Ltd | Administrative & support | 2022 |
| Salo Aesthetics Ltd | Health & social care | 2022 |
| Salon at NO 6 Ltd | Other services | 2015 |
| Salt & Pepper Kitchen Plymouth Ltd | Hospitality | 2024 |
| Salt Water Technologies Limited | Professional & scientific | 2024 |
| Saltash MMA Ltd | Arts & recreation | 2026 |
| Saltash Road Ltd | Households | 2017 |
| Saltash Road Properties Management Limited | Real estate | 2021 |
| Salumi Ltd | Hospitality | 2013 |
| Salutum Limited | Manufacturing | 2021 |
| SAM & Albert's Limited | Wholesale & retail | 2016 |
| SAM Allum Limited | Construction | 2011 |
| SAM Evans Ltd | Health & social care | 2018 |
| SAM Thompson Investments Ltd | Construction | 2024 |
| SAM Vacquier Motion Design Limited | Information & communication | 2015 |
| Sam's Place (Plymouth) Limited | Wholesale & retail | 2020 |
| Samand Management Limited | Real estate | 2009 |
| Sambowl Holdings Ltd | Financial services | 2026 |
| Sameday Refrigeration Ltd | Construction | 2021 |
| Samphire Vegan Deli Ltd | Hospitality | 2019 |
| Samsess IT Limited | Information & communication | 2011 |
| Samson Fishing Ltd | Wholesale & retail | 2017 |
| Samuel Oliver Consulting Limited | Professional & scientific | 2016 |
| Samuels SW Ltd | Construction | 2025 |
| SAN Shui U.K. Ltd | Hospitality | 2019 |
| Sand & Sushi Designs Limited | Professional & scientific | 2015 |
| Sand Sports Limited | Wholesale & retail | 2010 |
| Sandbar Investment Group Limited | Professional & scientific | 2020 |
| Sanderson General Building Ltd | Construction | 2021 |
| Sanderson Group (SW) Ltd | Financial services | 2025 |
| Sanderson Lettings SW Ltd | Real estate | 2026 |
| Sanderson Waste Removal Limited | Water & waste | 2022 |
| Sandon Court Owners RTM Company Limited | Other services | 2025 |
| Sandon Court Plymouth Ltd | Households | 2021 |
| Sands & Vossen Ltd | Construction | 2024 |
| Sandstone Property (SW) Ltd | Real estate | 2024 |
| Sandwells Car Care Centre Limited | Wholesale & retail | 2006 |
| Sandy G Properties Limited | Real estate | 2019 |
| Sangomas Associates Limited | Real estate | 2016 |
| Sano Logistics Ltd | Transport & logistics | 2025 |
| Sanome Ltd | Professional & scientific | 2021 |
| Sansiforyou Ltd | Wholesale & retail | 2025 |
| Santillo LGV Limited | Transport & logistics | 2016 |
| Sapa Holdings Limited | Real estate | 2015 |
| Saphira Jewellers Limited | Wholesale & retail | 2007 |
| Sappho's Cafe C.I.C. | Hospitality | 2025 |
| Sara PL1 Ltd | Wholesale & retail | 2024 |
| Sara's Petite Cuisine Ltd | Hospitality | 2017 |
| Sarah Lush Beauty Ltd | Other services | 2025 |
| Sarah's Forest Limited | Education | 2023 |
| Sarah-Louise Lingerie Ltd | Extraterritorial | 2011 |
| Sarastra Ltd | Professional & scientific | 2023 |
| Sardar Car Wash Ltd | Administrative & support | 2023 |
| Sarel Jewellers Limited | Professional & scientific | 2017 |
| SAS East Street Newquay Limited | Real estate | 2024 |
| SAS Harbour Avenue Limited | Transport & logistics | 2022 |
| SAS Photos Limited | Professional & scientific | 2014 |
| SAS ST Blazey Foundry Limited | Financial services | 2024 |
| Sash Lettings Ltd | Real estate | 2021 |
| Sassy Events Ltd | Hospitality | 2018 |
| SAT Subsea Ltd | Professional & scientific | 2026 |
| Satara Diagnostics Ltd | Health & social care | 2019 |
| Sauman Ltd | Hospitality | 2019 |
| Saunders Media Ltd | Information & communication | 2022 |
| Saunton Estates Ltd | Wholesale & retail | 2003 |
| Save on Limited | Financial services | 2003 |
| Savi Financial Planning Ltd | Professional & scientific | 2025 |
| Saving Lives in Macedonia CIC | Other services | 2025 |
| Savvy Students Ltd | Real estate | 2012 |
| Sawanclub Limited | Hospitality | 2024 |
| Sawyer Developments SW Ltd | Construction | 2025 |
| Saxicola Ltd | Professional & scientific | 2011 |
| Sayocall Ltd | Information & communication | 2026 |
| SAZ Salon Ltd | Other services | 2018 |
| Sazan (SW) Ltd | Administrative & support | 2018 |
| Sazi Bespoke Finishings Ltd | Construction | 2016 |
| SB Plymouth Limited | Hospitality | 2021 |
| Sb-Bk Ltd | Professional & scientific | 2019 |
| Sbcs Healthcare Group Ltd | Education | 2025 |
| SBD Group (SW) Ltd | Construction | 2025 |