| Ryder Investment Property Ltd | Real estate | 2025 |
| Ryder Voisey Ltd | Real estate | 2021 |
| Rydings Associates Limited | Real estate | 2004 |
| Ryearch Limited | Construction | 1990 |
| Ryno Build Ltd | Construction | 2018 |
| S & a (North East) Limited | Real estate | 2014 |
| S & B Engineering (SW) Ltd | Professional & scientific | 2021 |
| S & E Solutions Limited | Financial services | 2005 |
| S & J Procurement Ltd | Real estate | 2024 |
| S & J Services (Plymouth) Ltd | Real estate | 2024 |
| S & N Takeaway Limited | Hospitality | 2019 |
| S & S Surveyors Ltd | Professional & scientific | 2007 |
| S 007 Limited | Hospitality | 2015 |
| S and K Futures Limited | Hospitality | 2003 |
| S and S Decorators Ltd | Construction | 2000 |
| S Borlase Psychology Ltd | Education | 2024 |
| S Cameron Ltd | Construction | 2003 |
| S E Hospitality Ltd | Professional & scientific | 2022 |
| S Ellis Properties Ltd | Real estate | 2026 |
| S F Decorators Holdings Ltd | Financial services | 2025 |
| S F Decorators Ltd | Construction | 2010 |
| S F Restaurant Ltd | Hospitality | 2018 |
| S G Heath & Co. Ltd. | Professional & scientific | 2011 |
| S Goss Ltd | Wholesale & retail | 2025 |
| S J P (Cornwall) Limited | Real estate | 2005 |
| S J Pearce Transport Limited | Transport & logistics | 2006 |
| S J Revivals Ltd | Other services | 2017 |
| S L Powder Coatings Limited | Extraterritorial | 2013 |
| S Laurie Contracts Ltd | Construction | 2014 |
| S Luke & SON | | 1985 |
| S Molyneux Builders Limited | Construction | 2004 |
| S O'Leary Wall & Floor Tiling Contractors Ltd | Construction | 2013 |
| S P Harvey Electrical Limited | Construction | 2000 |
| S R Training Commercial Limited | Education | 2013 |
| S Salam Ltd | Other services | 2018 |
| S Treon Ltd | Health & social care | 2019 |
| S Trott Electrical Services Ltd | Construction | 2014 |
| S&B 4X4 Ltd | Wholesale & retail | 2024 |
| S&D Builders (SW) Ltd | Construction | 2022 |
| S&F Transports Global Limited | Wholesale & retail | 2026 |
| S&H Haulage Kent Ltd | Transport & logistics | 2018 |
| S&J Property Refurbishment Ltd | Manufacturing | 2020 |
| S&J Trowels Ltd | Construction | 2025 |
| S&L Domestic and Commercial Cleaning Services Ltd | Administrative & support | 2025 |
| S&R Plymouth Ltd | Real estate | 2020 |
| S&Sjohnstone Ltd | Construction | 2026 |
| S.A.D. Flooring Ltd | Construction | 2018 |
| S.A.S.S(Plymouth) Ltd | Other services | 2022 |
| S.C. COX Building Contractors Limited | Construction | 2003 |
| S.C. Developments (Plymouth) Limited | Real estate | 2006 |
| S.I.Building Contractors Limited | Construction | 2019 |
| S.L.Electrics SW Ltd | Construction | 2025 |
| S.M. Stevens & Co. Limited | Professional & scientific | 2003 |
| S.M.P. Pipe Systems Limited | Manufacturing | 1997 |
| S.P.C. Computers Limited | Other services | 2000 |
| S.P.J. Road Haulage Limited | Transport & logistics | 2002 |
| S.Scott Mechanical Services Limited | Manufacturing | 2014 |
| S.W.P. Hydraulics Ltd. | Manufacturing | 1996 |
| S.Wrightnuclearservice Limited | Construction | 2018 |
| S2 Group Services Ltd | Construction | 2015 |
| S2 Water Solutions Ltd | Other services | 2021 |
| S4TEK Limited | Professional & scientific | 2016 |
| SAA Consultants Limited | Information & communication | 1988 |
| SAB Security Southwest Limited | Administrative & support | 2024 |
| Saba & Molo Ltd | Transport & logistics | 2019 |
| Sabaton Security & Training Ltd | Administrative & support | 2023 |
| Sable Marketing Limited | Professional & scientific | 2024 |
| Sabr Industries Holdings Ltd | Financial services | 2023 |
| Sabr Industries Ltd | Real estate | 2022 |
| Sackville Limited | Real estate | 2018 |
| SAE Consultancy Ltd | Information & communication | 2025 |
| Safe Breaks Holidays Limited | Other services | 2010 |
| Safe Construction Training Solutions Ltd | Construction | 2025 |
| Safe Harbour Partnership Limited | Real estate | 2025 |
| Safe PCI Limited | Real estate | 2016 |
| Safe Ride Alliance Ltd | Transport & logistics | 2023 |
| Safe Scaffolding and Access Solutions Limited | Construction | 2017 |
| Safe Signal South West Ltd | Professional & scientific | 2019 |
| Safe Space Consultancy Limited | Other services | 2016 |
| Safeclean Kernow Limited | Other services | 2017 |
| Safeguard ICT Limited | Information & communication | 2017 |
| Safeguarding Consultants UK Ltd | Other services | 2023 |
| Safety Case Solutions Limited | Professional & scientific | 2005 |
| Safety First Holdings (South West) Limited | Administrative & support | 2011 |
| Safety First Manufacturing Group Limited | Manufacturing | 2022 |
| Safety Zone Traffic Management Ltd | Transport & logistics | 2018 |
| Safewear SW Limited | Wholesale & retail | 2017 |
| Saffrons Homes Limited | Real estate | 2022 |
| Sagatron Ltd | Manufacturing | 2018 |
| Sage Reach Ltd | Professional & scientific | 2024 |
| Sagres Limited | Financial services | 2023 |
| Sahab Collective Ltd | Information & communication | 2026 |
| Sahara Online Limited Company Ltd | Wholesale & retail | 2020 |
| Saheed 2024 Limited | Health & social care | 2023 |
| Sahodar UK | Professional & scientific | 2012 |
| SAI Forecourts Limited | Wholesale & retail | 2015 |
| Sai@Beauty Salon Ltd | Other services | 2018 |
| Sai@Beauty Studio Limited | Other services | 2018 |
| Saidfood Ltd | Hospitality | 2024 |
| Sail and Power Courses Limited | Administrative & support | 2014 |