| Yafle Catering Ltd | Hospitality | 2017 |
| Yamas(Looe) Ltd | Hospitality | 2023 |
| Yang Woolwell Ltd | Hospitality | 2020 |
| Yard ARM Plymouth Limited | Hospitality | 2023 |
| YAY! Group UK Limited | Hospitality | 2019 |
| Ycet Community Interest Company | Transport & logistics | 2022 |
| YDB (Electrical) Limited | | 1974 |
| Yealm Kitchens Ltd | Manufacturing | 2009 |
| Yealm Motor Services Limited | Wholesale & retail | 1999 |
| Yealmpton Agricultural Association | Other services | 1996 |
| Yealmpton Mill Management Co. Limited | Households | 1999 |
| Yelland's Limited | Hospitality | 2003 |
| Yellowbird Ltd | Professional & scientific | 2014 |
| Yelwor Building & Construction Limited | Construction | 2024 |
| Yeoman Electrical Services South West Ltd | Construction | 2024 |
| Yeomatix Limited | Professional & scientific | 2020 |
| Yeos Ltd | Households | 2025 |
| YES Developments Ltd | Construction | 2007 |
| Yesnaby Ltd | Wholesale & retail | 2021 |
| Yeti Enterprises Ltd | Real estate | 2020 |
| Ying's DIP DIP Limited | Wholesale & retail | 2007 |
| YJW Change Management Consulting Ltd | Professional & scientific | 2015 |
| Ymca Plymouth Ltd | Education | 1997 |
| YML Property Management Ltd | Construction | 2018 |
| Ynot Support C.I.C. | Information & communication | 2026 |
| Yofihouse Ltd | Manufacturing | 2025 |
| Yoga Blend Ltd | Wholesale & retail | 2019 |
| Yoga Loft Ltd | Health & social care | 2018 |
| Yoke the Salon Limited | Other services | 2017 |
| Yomari Cafe Ltd | Wholesale & retail | 2025 |
| Yorke Haykir LLP | | 2017 |
| Yorke Haykir Property Management Limited | Real estate | 2022 |
| YOU Again Ltd. | Professional & scientific | 2017 |
| YOU OWE YOU Ltd | Other services | 2020 |
| Young Vibes Ltd | Health & social care | 2023 |
| Youprotect Limited | Financial services | 2019 |
| Your Accounts Matter Ltd | Professional & scientific | 2019 |
| Your AI Journey Ltd | Information & communication | 2015 |
| Your Choice Care & Support Ltd | Health & social care | 2019 |
| Your Greener Solutions Limited | Financial services | 2020 |
| Your Perfect Mortgage Ltd | Financial services | 2019 |
| Your Voice Heard Advocacy Ltd | Health & social care | 2025 |
| Yours Directly Limited | Wholesale & retail | 2026 |
| Yourway Support Services Limited | Health & social care | 2007 |
| Yousuf's Indian & Thai Kitchen Ltd | Hospitality | 2023 |
| Youth Enquiry Service (Plymouth) Limited | Information & communication | 1995 |
| YS Coatings Limited | Administrative & support | 2023 |
| Yssr Ltd | Health & social care | 2024 |
| Yuki SAN Limited | Hospitality | 2016 |
| YUM YUM Foods South West Ltd | Manufacturing | 2021 |
| Yummy Plymouth Ltd | Hospitality | 2022 |
| Z&K Property Ltd | Real estate | 2021 |
| Z&K Rose 4 YOU Ltd | Wholesale & retail | 2023 |
| ZA Carpentry Ltd | Construction | 2016 |
| Zabucar Ltd | Construction | 2023 |
| Zafar Beyond Ltd | Wholesale & retail | 2026 |
| Zaitoon Restaurant Plymouth Ltd | Hospitality | 2025 |
| Zamamedia Ltd | Information & communication | 2025 |
| Zambezi Publishing Limited | Information & communication | 1997 |
| Zara Star Limited | Health & social care | 2014 |
| Zayo Design Studio Ltd | Manufacturing | 2017 |
| Zaza Transport Ltd | Other services | 2022 |
| Zbanghii Construction Ltd | Construction | 2025 |
| Zeath @ the Bay Limited | Construction | 2024 |
| Zeath @ the Beach Limited | Construction | 2024 |
| Zeath Developments Limited | Construction | 2023 |
| Zeath Holdings Cornwall Limited | Financial services | 2024 |
| Zeath Holdings Limited | Financial services | 2024 |
| ZED Building Services Limited | Construction | 2021 |
| ZED Construction Limited | Construction | 2019 |
| Zeena Ltd | Information & communication | 2018 |
| Zener Engineering Ltd | Professional & scientific | 2020 |
| Zenith Academy C.I.C. | Education | 2012 |
| Zenith Building Services South West Ltd | Construction | 2016 |
| Zenith Rentals SW Ltd | Real estate | 2023 |
| Zephyr Burgers Ltd | Hospitality | 2020 |
| Zephyr Food Ltd | Hospitality | 2017 |
| Zero Yachts Ltd | Manufacturing | 2022 |
| Zespa Media Limited | Information & communication | 2010 |
| Zest Event Catering Ltd | Hospitality | 2026 |
| Zfaral Limited | Professional & scientific | 2017 |
| Zimnikova Ltd | Health & social care | 2012 |
| Zipbar Limited | Hospitality | 2012 |
| Zirconi Ltd | Wholesale & retail | 2025 |
| ZM Spice Ltd | Hospitality | 2022 |
| Zoki Holdings Limited | Financial services | 2020 |
| Zomax Fitness Ltd | Arts & recreation | 2025 |
| Zonga LP | | 2011 |
| Zoommail Limited | Information & communication | 2018 |
| Zordan Risk Associates Ltd | Professional & scientific | 2015 |
| Zuzimo Intercontinental Restaurant Limited | Hospitality | 2013 |
| Zvriko Limited | Wholesale & retail | 2025 |
| Zycore Industries Ltd | Information & communication | 2021 |
| Zyoon Ltd | Wholesale & retail | 2025 |
| Áurea Studios Limited | Other services | 2026 |
| Ø Promotions Limited | Arts & recreation | 2023 |